Inflammation: Genomics & Stratified Medicine

Stratified Medicine for Arthritis: Within the inflammation theme Pitzalis has used the MRC Cohort Strategic Funding (700K) to create and lead the Pathobiology of Early Arthritis Cohort (PEAC) a consortium across 5 national centres of excellence.

This has created a unique National Resource of ultrasound directed synovial biopsy in rheumatoid arthritis from which we developed a major international partnership with Genentech-Roche. This has enabled multiple international industrial partnerships and led to the award of the MRC/AR-UK MATURA (£4.7m) and an NIHR funded Stratified Medicine Programmes testing whether synovial pathobiology can stratify biologic response in rheumatoid arthritis (Pitzalis £5.9M).

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