Inflammation

Our research is devoted to the study of novel mechanisms controlling immunity and inflammation in the joint, vasculature and diseased organ including heart and kidney. This Experimental Medicine programme aims to discover the mechanisms behind leukocyte trafficking, develop new gene therapies, anti-inflammatory peptides, agonists and antagonists that target novel inflammatory pathways, with a unique focus on endogenous mediators of resolution. 

Our translational research is published in Science, Nature Immunology and the Journal of Experimental Medicine - and the excellence of our research is recognised by the award of the Arthritis Research UK Early Arthritis Treatment Centre and an NIHR Translational Research Partnership. There is significant overlap with the aims of our cardiovascular research theme.

Major impact

  • We lead translational research on rheumatoid arthritis patient stratification, with the aim of adopting the cancer model (from tissue pathotype to personalised therapy)
  • We pioneered the area of Resolution of Inflammation identifying distinct mediators and receptor targets
  • We made fundamental discoveries on the process of leukocyte trafficking, with translational relevance to organ transplantation
  • Collectively, for REF2014, we have published in Nature, Nature Immunology (x3), Nature Cell Biology, J Exp Med (x2), J Clin Invest, J Cell Biol (x2), PNAS (x2), Blood (x3), Circulation Research and several articles in J Immunol, Arthritis & Rheumatism and Annals of Rheumatic Diseases.

 Current grant awards

  • 1 Wellcome Trust Senior Investigator Award
  • 3 Wellcome Programme Grants (£3 million), 1 BHF programme Grant
  • MRC/Arthritis Research UK MATURA Consortium for Stratified Medicine (£4.7m)
  • MRC Pathobiology of Early Arthritis Cohort (£681K)
  • NIHR Experimental Medicine Evaluation Programme for Stratified Medicine (£1.2million)
  • 3 EU Programmes.

Training

  • Oliver Bird PhD Studentship Scheme in Rheumatology (Nuffield Foundation)
  • Multiple British Heart Foundation and Arthritis Research UK Fellowships
  • Awarded MRC MRes/PhDs cardiovascular and inflammation in-vivo research awarded in 2012.

Key partnerships and clinical links

  • We are linked to the Barts Health NHS Trust Musculoskeletal Clinical Service connecting bench to the clinic
  • We have a strong partnership with UCL Rheumatology and a joint Research Strategy
  • Current industrial partners are Genentech/Roche, MedImmune/AstraZeneca, UCB Pharma and MRC Technology

Find out more about research at the WHRI

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