Sussan Nourshargh, FMedSci

Head of Centre for Microvascular Research & Professor of Microvascular Pharmacology

Sussan Nourshargh is a pharmacologist who studied at University College London (BSc) and King’s College London (PhD) and became Professor of Immunopharmacology at Imperial College London in 2006. In 2007 she joined Barts and The London Medical School to establish and head a new Centre focusing on Microvascular Research.

Fellowships

  •  Wellcome Trust Senior Investigator Award (2012)  
  •  Fellow of the Academy of Medical Sciences (2012)
  •  Fellow of the Society of Biology (2010)
  •  Fellow of the British Pharmacological Society (2005)
  •  Wellcome Trust University Award (1996)
  • Wellcome Trust Career Development Fellowship (1990)

 
External activities

  • Member of the British Heart Foundation Fellowship Committee (2011 to 2014)
  • Member of The Wellcome Trust’s Peer Review College (2012 to date)
  • Chair and Member of the Academy of Medical Sciences Committee (SC3) for selection of new Fellows (2012 to date)  
  • Treasurer of the UK Adhesion Society (2007 to date)   
  • Editor of European Journal of Immunology (2013 to date)
  • Editor of British Journal of Pharmacology (2010-2013)
  • Royal Society’s Newton Advanced Fellowship Panel (2014 to 2017)

Summary of Research

The principal objective of our research is to investigate the mode, dynamics and mechanisms of leukocyte transmigration, the final stage in the leukocyte adhesion cascade that describes the movement of leukocytes from the vascular lumen into inflamed and/or injured tissues. To achieve this goal we rigorously investigate the interactions of leukocytes with different components of microvessel walls (endothelial cells, pericytes and the vascular basement membrane) using both physiologically relevant as well as pathological inflammatory models. A key component of our work is a research programme that investigates how pathological inflammatory insults impact the dynamics of neutrophil-vessel wall interactions and the implications of disrupted modes of neutrophil transmigration (eg neutrophil reverse transmigration) on inflammatory disease development and dissemination. Collectively through the application of advanced imaging platforms such as confocal intravital microscopy to analyse leukocyte-vessel wall interactions in vivo, our work aims to unravel previously unexplored cellular and molecular physiological concepts and identify disease-specific phenomena.

Our work is largely funded by the Wellcome Trust (Senior Investigator Award) and several grants from the British Heart Foundation and the Arthritis Research UK.

Members of the Group

Academics: James Whiteford (Lecturer; HEFCE), Mathieu-Benoit Voisin (Lecturer; AR-UK), Abigail Woodfin (Lecturer; BHF) and Tom Nightingale (Lecturer; ECR)

Honorary Academics: Tim Williams; Robin Poston
Research staff: Bartomeu Colom; Tamara Girbl; Amy Sawtell, Natalia Reglero, Victoria Jones; Steven Morrell
PhD students: Andrew Leese; Giulia De Rossi; Catherine Pickworth; Robert Beal; Samantha Arokiasamy
Support staff: Matthew Golding (Lab Manager); Andy Vaughan (Centre Administrator)

Key Publications

Nourshargh S and Alon R. Leukocyte migration into inflamed tissues: cross-talks between effector leukocytes and venular walls. Immunity, in press (2014).

Finsterbusch M., Voisin M-B., Beyrau M., Williams T. J. and Nourshargh S. Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. J Exp Med., 21:1307-1314 (2014).


Leinster D.A., Colom B., Whiteford J. R., Ennis D. P., Lockley M., McNeish I. A., Aurrand-Lions M., Chavakis T., Imhof B. A., Balkwill F. R. and Nourshargh S. Endothelial cell junctional adhesion molecule-C plays a key role in the development of tumours in a murine model of ovarian cancer. FASEB J., 27: 4244-4253 (2013).

Proebstl, D., M.B. Voisin, A. Woodfin, J. Whiteford, F. D'Acquisto, G.E. Jones, D. Rowe and S. Nourshargh. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med., 209:1219-34 (2012).
    
Colom, B., Y. Poitelon, W. Huang, A. Woodfin, S. Averill, U. Del Carro, D. Zambroni, S.D. Brain, M. Perretti, A. Ahluwalia, J.V. Priestley, T. Chavakis, B.A. Imhof, M.L. Feltri and S. Nourshargh. Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. FASEB J., 26:1064-76 (2012).

Woodfin, A., M.B. Voisin, M. Beyrau, B. Colom, D. Caille, F.M. Diapouli, G.B. Nash, T. Chavakis, S.M. Albelda, G.E. Rainger, P. Meda, B.A. Imhof and S. Nourshargh. The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol., 12:761-9 (2011).

Nourshargh, S., P.L. Hordijk and M. Sixt. Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol., 11:366-78 (2010)

Voisin, M.B., D. Probstl and S. Nourshargh. Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation. Am J Pathol., 176:482-95 (2010).

Scheiermann, C., B. Colom, P. Meda, N.S. Patel, M.B. Voisin, A. Marrelli, A. Woodfin, C. Pitzalis, C. Thiemermann, M. Aurrand-Lions, B.A. Imhof and S. Nourshargh. Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol., 29:1509-15 (2009).

Voisin, M.B., A. Woodfin and S. Nourshargh. Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo. Arterioscler Thromb Vasc Biol., 29:1193-9 (2009).

Woodfin, A., M.B. Voisin, B.A. Imhof, E. Dejana, B. Engelhardt and S. Nourshargh. Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood, 113:6246-57 (2009).

Scheiermann, C., P. Meda, M. Aurrand-Lions, R. Madani, Y. Yiangou, P. Coffey, T.E. Salt, D. Ducrest-Gay, D. Caille, O. Howell, R. Reynolds, A. Lobrinus, R.H. Adams, A.S. Yu, P. Anand, B.A. Imhof and S. Nourshargh. Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science, 318:1472-5 (2007).

Ley, K., C. Laudanna, M.I. Cybulsky and S. Nourshargh. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol.,7:678-89 (2007).

Woodfin, A., C.A. Reichel, A. Khandoga, M. Corada, M.B. Voisin, C. Scheiermann, D.O. Haskard, E. Dejana, F. Krombach and S. Nourshargh. JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood, 110: 1848-56 (2007).

Wang, S., M.B. Voisin, K.Y. Larbi, J. Dangerfield, C. Scheiermann, M. Tran, P.H. Maxwell, L. Sorokin and S. Nourshargh. Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J Exp Med., 203:1519-32 (2006).

Huang, M.T., K.Y. Larbi, C. Scheiermann, A. Woodfin, N. Gerwin, D.O. Haskard and S. Nourshargh. ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration. Blood,107:4721-7 (2006).

PubLists Publications

De Rossi G, Evans AR, Kay E et al. (2014). Shed syndecan-2 inhibits angiogenesis.. J Cell Sci Vol., () -.
10.1242/jcs.153015
Finsterbusch M, Voisin MB, Beyrau M et al. (2014). Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.. J Exp Med Vol.211, (7) 1307-1314.
10.1084/jem.20132413
Halai K, Whiteford J, Ma B et al. (2014). ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.. J Cell Sci Vol.127, (Pt 3) 620-629.
10.1242/jcs.137463
Leinster DA, Colom B, Whiteford JR et al. (2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.. FASEB J Vol.27, (10) 4244-4253.
10.1096/fj.13-230441
Brancaleone V, Gobbetti T, Cenac N et al. (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.. Blood Vol.122, (4) 608-617.
10.1182/blood-2013-04-496661
Alazawi W, Heath H, Waters JA et al. (2013). Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.. Proc Natl Acad Sci U S A Vol.110, (21) 8656-8661.
10.1073/pnas.1221652110
Nourshargh S (2013). L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation.. Presse Med Vol.42, (4 Pt 2) 0755-4982 498-499.
10.1016/j.lpm.2013.01.004
Alon R, Nourshargh S (2013). Learning in motion: pericytes instruct migrating innate leukocytes.. Nat Immunol Vol.14, (1) 14-15.
10.1038/ni.2489
Voisin MB, Nourshargh S (2013). Neutrophil transmigration: emergence of an adhesive cascade within venular walls.. J Innate Immun Vol.5, (4) 336-347.
10.1159/000346659
Beyrau M, Bodkin JV, Nourshargh S (2012). Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.. Open Biol Vol.2, (11) 120134-.
10.1098/rsob.120134
Ma L, Cheung KC, Kishore M et al. (2012). CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.. J Immunol Vol.189, (8) 4104-4111.
10.4049/jimmunol.1201739
Avari P, Huang W, Averill S et al. (2012). The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.. Brain Behav Vol.2, (4) 402-414.
10.1002/brb3.63
Proebstl D, Voisin MB, Woodfin A et al. (2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.. J Exp Med Vol.209, (6) 1219-1234.
10.1084/jem.20111622
Leinster DA, Kulbe H, Everitt G et al. (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer.. J Pathol Vol.227, (2) 136-145.
10.1002/path.4002
Colom B, Poitelon Y, Huang W et al. (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.. FASEB J Vol.26, (3) 1064-1076.
10.1096/fj.11-196220
Kishore M, Ma L, Cornish G et al. (2012). Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.. PLoS One Vol.7, (6) e39433-.
10.1371/journal.pone.0039433
Whiteford JR, Xian X, Chaussade C et al. (2011). Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.. Mol Biol Cell Vol.22, (19) 3609-3624.
10.1091/mbc.E11-02-0099
Woodfin A, Voisin MB, Beyrau M et al. (2011). The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.. Nat Immunol Vol.12, (8) 761-769.
10.1038/ni.2062
Veninga H, de Groot DM, McCloskey N et al. (2011). CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism.. J Leukoc Biol Vol.89, (3) 413-421.
10.1189/jlb.0510280
Ma L, Mauro C, Cornish GH et al. (2010). Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.. Proc Natl Acad Sci U S A Vol.107, (45) 19461-19466.
10.1073/pnas.1011748107
Nourshargh S, Hordijk PL, Sixt M (2010). Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.. Nat Rev Mol Cell Biol Vol.11, (5) 366-378.
10.1038/nrm2889
Leoni G, Voisin MB, Carlson K et al. (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature.. Br J Pharmacol Vol.160, (1) 171-180.
10.1111/j.1476-5381.2010.00688.x
Woodfin A, Voisin MB, Nourshargh S (2010). Recent developments and complexities in neutrophil transmigration.. Curr Opin Hematol Vol.17, (1) 9-17.
10.1097/MOH.0b013e3283333930
Voisin MB, Pröbstl D, Nourshargh S (2010). Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.. Am J Pathol Vol.176, (1) 482-495.
10.2353/ajpath.2010.090510
Scheiermann C, Colom B, Meda P et al. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.. Arterioscler Thromb Vasc Biol Vol.29, (10) 1509-1515.
10.1161/ATVBAHA.109.187559
Voisin MB, Woodfin A, Nourshargh S (2009). Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.. Arterioscler Thromb Vasc Biol Vol.29, (8) 1193-1199.
10.1161/ATVBAHA.109.187450
Woodfin A, Voisin MB, Imhof BA et al. (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. BLOOD Vol.113, (24) 0006-4971 6246-6257.
10.1182/blood-2008-11188375
Woodfin A, Voisin MB, Imhof BA et al. (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.. Blood Vol.113, (24) 6246-6257.
10.1182/blood-2008-11-188375
Little MA, Smyth L, Salama AD et al. (2009). Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.. Am J Pathol Vol.174, (4) 1212-1220.
10.2353/ajpath.2009.080458
Woodfin A, Voisin MB, Nourshargh S (2007). PECAM-1: a multi-functional molecule in inflammation and vascular biology.. Arterioscler Thromb Vasc Biol Vol.27, (12) 2514-2523.
10.1161/ATVBAHA.107.151456
Scheiermann C, Meda P, Aurrand-Lions M et al. (2007). Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves.. Science Vol.318, (5855) 1472-1475.
10.1126/science.1149276
Bradfield PF, Nourshargh S, Aurrand-Lions M et al. (2007). JAM family and related proteins in leukocyte migration (Vestweber series).. Arterioscler Thromb Vasc Biol Vol.27, (10) 2104-2112.
10.1161/ATVBAHA.107.147694
Bradfield PF, Scheiermann C, Nourshargh S et al. (2007). JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.. Blood Vol.110, (7) 0006-4971 2545-2555.
10.1182/blood-2007-03-078733
Woodfin A, Reichel CA, Khandoga A et al. (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.. Blood Vol.110, (6) 0006-4971 1848-1856.
10.1182/blood-2006-09-047431
Ley K, Laudanna C, Cybulsky MI et al. (2007). Getting to the site of inflammation: the leukocyte adhesion cascade updated.. Nat Rev Immunol Vol.7, (9) 678-689.
10.1038/nri2156
NOURSHARGH S, Krombach F, Dejana E et al. (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: Evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood Vol.110, (6) 0006-4971 1848-1856.
10.1182/blood-2006-09-047431
Young RE, Voisin MB, Wang S et al. (2007). Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.. Br J Pharmacol Vol.151, (5) 0007-1188 628-637.
10.1038/sj.bjp.0707267
Voisin MB, Woodfin A, Nourshargh S (2007). Neutrophil and monocyte transmigration elicited by ischemia/reperfusion (I/R) injury and CCL2 is associated with remodelling of the venular basement membrane (BM) in vivo. FASEB JOURNAL Vol.21, (5) 0892-6638 A127-A127.
Woodfin A, Larbi K, Krombach F et al. (2007). PECAM-1 & JAM-A mediate leukocyte transmigration in a stimulus-specific manner: Is this phenomenon governed by the strain of mice investigated?. FASEB JOURNAL Vol.21, (5) 0892-6638 A127-A127.
Potter PK, Larbi KY, Nourshargh S et al. (2007). Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1.. Mol Immunol Vol.44, (6) 0161-5890 1135-1140.
10.1016/j.molimm.2006.07.002
Nourshargh S, Krombach F, Dejana E (2006). The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues.. J Leukoc Biol Vol.80, (4) 0741-5400 714-718.
10.1189/jlb.1105645
Huang MT, Larbi KY, Scheiermann C et al. (2006). ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration.. Blood Vol.107, (12) 0006-4971 4721-4727.
10.1182/blood-2005-11-4683
Wang S, Voisin MB, Larbi KY et al. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.. J Exp Med Vol.203, (6) 0022-1007 1519-1532.
10.1084/jem.20051210
Woodfin A, Reichel C, Khandoga A et al. (2006). JAM-A mediates leukocyte transmigration in a stimulus-specific manner. FASEB JOURNAL Vol.20, (5) 0892-6638 A862-A862.
Voisin MB, Woodfin A, Dawes T et al. (2006). Neutrophil elastase (NE) deficient mice exhibit reduced leukocyte transmigration in response to ischaemia/reperfusion (I/R) injury. FASEB JOURNAL Vol.20, (5) 0892-6638 A1083-A1083.
Voisin MB, Wang SJ, Larbi K et al. (2006). Neutrophils play a direct role in enhancing the size of venular basement membrane (BM) matrix protein low expression regions. FASEB JOURNAL Vol.20, (5) 0892-6638 A1322-A1322.
Tharp WG, Yadav R, Irimia D et al. (2006). Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo.. J Leukoc Biol Vol.79, (3) 0741-5400 539-554.
10.1189/jlb.0905516
Reichel CA, Khandoga A, Woodfin A et al. (2006). JAM-A mediates leukocyte transmigration dynamically and in a stimulus-specific manner. JOURNAL OF VASCULAR RESEARCH Vol.43, (6) 1018-1172 576-576.
Little MA, Bhangal G, Smyth CL et al. (2006). Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis.. J Am Soc Nephrol Vol.17, (1) 1046-6673 160-169.
10.1681/ASN.2005060616
Ambrose LR, Little MA, Nourshargh S et al. (2005). Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy.. Kidney Int Vol.68, (6) 0085-2538 2912-2913.
10.1111/j.1523-1755.2005.00583_10.x
Little MA, Pusey CD, Nourshargh S (2005). Intravital microscopy in the study of ANCA-associated systemic vasculitis.. Clin Nephrol Vol.64, (6) 0301-0430 465-470.
Little MA, Smyth CL, Yadav R et al. (2005). Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo.. Blood Vol.106, (6) 0006-4971 2050-2058.
10.1182/blood-2005-03-0921
Chatterjee BE, Yona S, Rosignoli G et al. (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro.. J Leukoc Biol Vol.78, (3) 0741-5400 639-646.
10.1189/jlb.0405206
Aurrand-Lions M, Lamagna C, Dangerfield JP et al. (2005). Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation.. J Immunol Vol.174, (10) 0022-1767 6406-6415.
Wang S, Dangerfield JP, Young RE et al. (2005). PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration.. J Cell Sci Vol.118, (Pt 9) 0021-9533 2067-2076.
10.1242/jcs.02340
Huang MT, Larbi KY, Gerwin N et al. (2005). ICAM-2 mediates PECAM-1-independent neutrophil transmigration in vivo. FASEB JOURNAL Vol.19, (5) 0892-6638 A1504-A1505.
Voisin MB, Young R, Dangerfield J et al. (2005). LTB4 is a potent inducer of cell surface neutrophil elastase (NE), a response that appears to play a role in LTB4-induced neutrophil transmigration in vivo. FASEB JOURNAL Vol.19, (5) 0892-6638 A1717-A1717.
Wang SJ, Dangerfield J, Voisin MB et al. (2005). Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane. FASEB JOURNAL Vol.19, (5) 0892-6638 A1504-A1504.
Nourshargh S, Marelli-Berg FM (2005). Transmigration through venular walls: a key regulator of leukocyte phenotype and function.. Trends Immunol Vol.26, (3) 1471-4906 157-165.
10.1016/j.it.2005.01.006
Dangerfield JP, Wang S, Nourshargh S (2005). Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in vivo.. J Leukoc Biol Vol.77, (2) 0741-5400 159-165.
10.1189/jlb.0704421
Marelli-Berg FM, James MJ, Dangerfield J et al. (2004). Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo.. Blood Vol.103, (8) 0006-4971 3111-3116.
10.1182/blood-2003-08-2717
Young RE, Thompson RD, Larbi KY et al. (2004). Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo.. J Immunol Vol.172, (7) 0022-1767 4493-4502.
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J et al. (2004). Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.. J Immunol Vol.172, (6) 0022-1767 3406-3414.
McMillan SJ, Kearley J, Campbell JD et al. (2004). Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation.. J Immunol Vol.172, (4) 0022-1767 2586-2594.
Yadav R, Larbi KY, Young RE et al. (2003). Migration of leukocytes through the vessel wall and beyond. THROMBOSIS AND HAEMOSTASIS Vol.90, (4) 0340-6245 598-606.
10.1160/TH03-04-0220
James MJ, Belaramani L, Prodromidou K et al. (2003). Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism.. Blood Vol.102, (6) 0006-4971 2173-2179.
10.1182/blood-2003-02-0637
Marshall D, Dangerfield JP, Bhatia VK et al. (2003). MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha.. Rheumatology (Oxford) Vol.42, (8) 1462-0324 929-934.
10.1093/rheumatology/keg251
Larbi KY, Dangerfield JP, Nourshargh S (2003). MMP-9 regulates eosinophil transmigration and expression of CCR3 on transmigrated eosinophils in vivo. FASEB JOURNAL Vol.17, (5) 0892-6638 A1071-A1071.
Young RE, Thompson RD, Larbi KY et al. (2003). Neutrophil elastase (NE) plays a non-redundant role in zymosan-induced leukocyte migration. FASEB JOURNAL Vol.17, (5) 0892-6638 A1188-A1188.
Larbi KY, Dangerfield JP, Culley FJ et al. (2003). P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.. J Leukoc Biol Vol.73, (1) 0741-5400 65-73.
10.1189/jlb.0302126
Young RE, Thompson RD, Nourshargh S (2002). Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules.. Br J Pharmacol Vol.137, (8) 0007-1188 1237-1246.
10.1038/sj.bjp.0704981
Dangerfield J, Larbi KY, Huang MT et al. (2002). PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane.. J Exp Med Vol.196, (9) 0022-1007 1201-1211.
10.1084/jem.20020324
Marshall D, Dangerfield JD, Bhatia VK et al. (2002). MRL/lpr LUPUS-PRONE MICE SHOW EXAGGERATED ICAM-1 DEPENDENT LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN RESPONSE TO TNF alpha. RHEUMATOLOGY Vol.41, () 1462-0324 32-32.
Young RE, Thompson RD, Nourshargh S (2002). Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta (IL-1 beta) and factor-alpha (TNF alpha) in mouse cremasteric venules.. BRIT J PHARMACOL Vol.135, () 0007-1188 -.
Thompson RD, Noble KE, Larbi KY et al. (2001). Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane.. Blood Vol.97, (6) 0006-4971 1854-1860.
10.1182/blood.V97.6.1854
Marshall D, Bhatia VK, Ahmed S et al. (2001). Expression of P- but not E-selectin in peritoneal microvasculature during inflammatory peritonitis. FASEB J Vol.15, (4) 0892-6638 A328-A328.

Sponsors

News

Professor Sussan Nourshargh awarded the Astra Zeneca Prize Award for Women in Pharmacology from the British Pharmacology Society (2014)

Dr Tamara Girbl awarded an EU Horizon 2020 COFUND Fellowship (2014)

Dr Tamara Girbl awarded a BHF Immediate Post-doctoral Fellowship (2013)

Professor Sussan Nourshargh elected Fellow of the Academy of Medical Sciences (April 2012).

Professor Sussan Nourshargh awarded Wellcome Trust Senior Investigator Award (May 2012).

Dr. Mathieu-Benoit Voisin awarded Arthritis Research UK Fellowship (January 2012).

Dr. Mathieu-Benoit Voisin awarded Young Investigator Award (Best oral presentation) at the international meeting of “Neutrophil in Immunity”, Quebec, Canada (June 2012).

Dr. Martina Beyrau awarded Young Investigator Award (oral presentation) at WHRI Annual Review (July 2012).

Ms. Krishma Halai awarded runner-up prize in British Heart Foundation Reflections of Research Image Competition (May 2012).

Professor Beat Imhof (University of Geneva) joins Centre for Microvascular Research as a visiting Professor (April-June 2012).

Dr. Abigail Woodfin awarded the prestigious Servier Prize in Microcirculation at 26th European Congress for Microcirculation (June 2011).

Dr. Abigail Woodfin awarded British Heart Foundation Intermediate Basic Science Research Fellowship (April 2011).

Collaborators

Internal: Professor Federica Marelli-Berg (WHRI); Professor Chris Thiemermann (WHRI); Professor Mauro Perretti (WHRI);  Professor Karim Brohi (Trauma Centre)


External: Professor Beat Imhof (Geneva, Switzerland); Dr Michel Aurrand-Lions (Marseille, France); Professor Trian Chavakis (Dresden, Germany); Professor Peter Heeringa (Groningen, Netherlands); Professor Mark Little (Dublin, Ireland); Professor Ed Rainger (University of Birmingham)

Contact

Professor Sussan Nourshargh, PhD, FMedSci
Centre for Microvascular Research

William Harvey Research Institute
Barts and The London School of Medicine and Dentistry
Queen Mary, University of London

Charterhouse Square
London, EC1M 6BQ
T: +44 (0) 20 7882 8240 

E:  This email address is being protected from spambots. You need JavaScript enabled to view it.

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