Voisin, Mathieu-Benoit

Lecturer in Immunology, Co-Manager of the MIC-LIS Facility

Mathieu-Benoit Voisin graduated in 2000 from the University of Bordeaux II (France) in Biological Sciences with a specialisation in Immunology. He obtained his PhD from the University of Tours (France) in 2003 and conducted post-doctoral research with Prof. Nourshargh at Imperial College London. In 2007, he relocated with Prof. Nourshargh to the William Harvey Research Institute and is currently establishing his own independent research programme studying the lymphatic system. 


Summary of Research

Neutrophils are key effectors of the innate immune response but can also contribute to the development of many acute inflammatory diseases. There is also evidence for neutrophil involvement in the regulation of the adaptive immunity and the pathogenesis of numerous chronic inflammatory conditions such as rheumatoid arthritis. The precise role of neutrophils in this autoimmune disorder is unclear and the focus of my research is to elucidate the mechanisms of neutrophil migration into lymphatic vessels and lymph nodes following antigen-induced arthritis and their role in the regulation of the acquired immunity. The main hypothesis is that neutrophil entry into lymphatic vessels plays an important role in the initiation of autoimmune diseases by changes in their phenotypes and their entry to the lymphatic vascular system. The project thus aims to characterize the mechanisms of neutrophil/lymphatic vessel interactions in vivo as analysed by intravital confocal microscopy and the implications of this response to the development of arthritis. Collectively, the project will address a previously unexplored aspect of leukocyte biology and chronic disorders thus making a significant and novel contribution to the field of inflammation.

Lymphatic Vessel Architecture
Lymphatic Vessel Architecture 
Lymphatic vessel architecture (red) with neutrophils (green) post transmigration through blood vessels (green) during inflammation in vivo.

 
Neutrophil migration into lymphatic vessel
Neutrophil migration into lymphatic vessel
 Neutrophil (green) migration into lymphatic vessel (blue) as observed by live imaging in vivo.

Awards

• Young Investigator Award (Best oral presentation) at the international meeting of “Neutrophil in Immunity”, Quebec, Canada (June 2012)
• Werner Risau New Investigator Award in Vascular Biology from ATVB (2010)
• Descartes PhD Travel Award (Tours University, France / Dartmouth College, USA) (2002).

Fellowships

• Arthritis Research UK Career Development Fellowship (2012)

Memberships

• UK Cell Adhesion Committee member (2014 to date) Member of the Society for Leukocyte Biology (2015 to date)

Teaching

• Co-lead : Basic Immunology (Module BMD251) in Biomedical Sciences (BSc B990)
• Regular Lectures: Intercalated BMedSci students in Molecular Medicine & Pharmacology; Innovative Therapeutics (BSc B211, module BMD175) 

Members of the Group 

Current: To be appointed
Previous: Dr Samantha Arokiasamy, Dr Christian Zakian, Mr Maurizio Kazimierz-Parker, Mr William Migo, Mss Eleanor Peace, Mr Muhammad Tahsin

Key Publications

For a full list of publist publications click here

Arokiasamy S, Zakian C, Dilliway J, Wang W, Nourshargh S, Voisin MB (2017). Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Sci Rep. 2017 Mar 13;7:44189. doi: 10.1038/srep44189

Herrera C, Voisin MB, Escalante T, Rucavado A, Nourshargh S, Gutiérrez JM (2016). Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle. PLoS One. 2016 Dec 16;11(12):e0168643. doi: 10.1371/journal.pone.0168643.

Schnoor M*, Alcaide P*, Voisin MB*, van Buul JD*. (2015). Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation. Mediators Inflamm. 2015;2015:946509. doi: 10.1155/2015/946509.

Finsterbusch M, Voisin MB, Beyrau M, Williams TJ, Nourshargh S. (2014) Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. J Exp Med. 2014 Jun 30;211(7):1307-14. doi: 10.1084/jem.20132413

Voisin MB*, Proebstl D*, Woodfin A et al. (2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med Vol.209, (6) 1219-1234.
10.1084/jem.20111622 

Woodfin A, Voisin MB, Beyrau M et al. (2011). The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol Vol.12, (8) 761-769.
10.1038/ni.2062

Voisin MB, Pröbstl D, Nourshargh S (2010). Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation. Am J Pathol Vol.176, (1) 482-495.
10.2353/ajpath.2010.090510

Voisin MB, Woodfin A, Nourshargh S (2009). Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo. Arterioscler Thromb Vasc Biol Vol.29, (8) 1193-1199.
10.1161/ATVBAHA.109.187450.

Voisin MB*, Wang S*, Larbi KY et al. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J Exp Med Vol.203, (6) 0022-1007 1519-1532.
10.1084/jem.20051210

 

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