Postdoctoral Research Associate
Mathieu-Benoit Voisin graduated in 2000 from the University of Bordeaux II (France) in Biological Sciences with a specialisation in Immunology. He obtained his PhD from the University of Tours (France) in 2003 and conducted post-doctoral research with Prof. Nourshargh at Imperial College London. In 2007, he relocated with Prof. Nourshargh to the William Harvey Research Institute and is currently establishing his own independent research programme studying the lymphatic system.
Arthritis Research UK Career Development Fellowship (2012)
Summary of Research
Neutrophils are key effectors of the innate immune response but can also contribute to the development of many acute inflammatory diseases. There is also evidence for neutrophil involvement in the regulation of the adaptive immunity and the pathogenesis of numerous chronic inflammatory conditions such as rheumatoid arthritis. The precise role of neutrophils in this autoimmune disorder is unclear and the focus of my research is to elucidate the mechanisms of neutrophil migration into lymphatic vessels and lymph nodes following antigen-induced arthritis and their role in the regulation of the acquired immunity. The main hypothesis is that neutrophil entry into lymphatic vessels plays an important role in the initiation of autoimmune diseases by changes in their phenotypes and their entry to the lymphatic vascular system. The project thus aims to characterize the mechanisms of neutrophil/lymphatic vessel interactions in vivo as analyzed by intravital confocal microscopy and the implications of this response to the development of arthritis. Collectively, the project will address a previously unexplored aspect of leukocyte biology and chronic disorders thus making a significant and novel contribution to the field of inflammation.
Lymphatic vessel architecture (red) with neutrophils (green) post transmigration through blood vessels (green) during inflammation in vivo.
Neutrophil (green) migration into lymphatic vessel (blue) as observed by live imaging in vivo.
For a full list of publist publications click here
Proebstl D, Voisin MB, Woodfin A et al. (2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.. J Exp Med Vol.209, (6) 1219-1234.
Woodfin A, Voisin MB, Beyrau M et al. (2011). The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.. Nat Immunol Vol.12, (8) 761-769. 10.1038/ni.2062
Voisin MB, Pröbstl D, Nourshargh S (2010). Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.. Am J Pathol Vol.176, (1) 482-495. 10.2353/ajpath.2010.090510
Voisin MB, Woodfin A, Nourshargh S (2009). Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.. Arterioscler Thromb Vasc Biol Vol.29, (8) 1193-1199. 10.1161/ATVBAHA.109.187450
Wang S, Voisin MB, Larbi KY et al. (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.. J Exp Med Vol.203, (6) 0022-1007 1519-1532. 10.1084/jem.20051210