Mauro Perretti

 Co-director of WHRI/Professor of Immunopharmacology

Mauro PerrettiMauro has published over 280 papers, with >11,000 citations and an H Factor of 60 (Google Scholar).
After BSc in Pharmaceutical Chemistry (University in Florence, 1985) and a MSc in Pharmacology and Toxicology (1988), Mauro started his career at the Sclavo Research Centre under the leadership of Prof Luca Parente. In 1991 he joined Prof Rod Flower at the William Harvey Research Institute, and in 1996 he gained his PhD (LON).
Mauro career has been shaped by fellowships from the Arthritis Research Campaign, a post-doctoral one (1997-2002) followed by a senior fellowship (2002-2007). In 2001 Mauro gained his personal chair by Queen Mary University of London; in 2011 he took the Leadership of the Centre for Biochemical Pharmacology, with Prof Marelli-Berg as Deputy.  Since 2006 he acts as Deputy Director of the William Harvey Research Institute, a role he still carries on. 
Mauro is Fellow of the British Pharmacological Society (FBPharmacolS,  2004), of the Academia Europea (2010) and of the Society of Biology (2012).

Summary of Research

We pioneered the concept that acute inflammation resolves, naturally, by the engagement of endogenous mediators that activate a series of non-redundant processes (inhibition of immune cell trafficking, efferocytosis, tissue repair) typical of what we now call the Resolution of Inflammation. When resolution is malfunctioning it contributes to chronic inflammatory diseases. We study the pathophysiology of some pro-resolving pathways (eg. Annexin A1 and its peptides, Glucocorticoids+calcitonin, Melanocortins, omega-3 derivatives) and aim to identify novel receptors amenable for the development of innovative anti-inflammatory therapeutics. A current focus is on pro-resolving GPCRs, such as FPR2/ALX and MC3, establishing their expression in disease; homo/heterodimerization and discovering novel biological functions.
Molecular pharmacology and cell biology protocols are complemented by integrated biology models (intravital microscopy for vascular responses, peritonitis, paw oedema, airpouch) including models of disease (arthritis, myocardial infarct and stroke). Each project is different in its practicality since it is the scientific question that drives the experimental protocols to be applied or developed, hence creativity is a must!
We are acutely aware of the importance to assess the relevance of our research in clinical settings, as this would accelerate the development of innovative therapeutics modelled on resolution; currently the focus is on rheumatology, cardiac surgery, sepsis and vasculitides.

Expression of the pro-resolving receptor FPR2

Expression of the pro-resolving receptor FPR2 (a GPCR that transduces the actions of AnnexinA1 and Lipxin A4) as revealed by Green Florescence Protein detection, using a unique mouse colony  engineered with this reporter under FPR2 promoter (funded by The Wellcome Trust).

Microcapsules

Microcapsules (MC; green) can be used to deliver biologically active molecules to modulate the interaction between human leukocytes and the endothelium. (Collaboration with Prof Sukhorukov, QMUL).

Members of the Group

Research staff: J Cash; Lucy Norling; E Silverpil; S Cooray; T Gobbetti; M Kaneva; S McArthur; T Montero-Melendez; S Nadkarni; HB Patel; D Thompson; S Bena; A Doyle; B Gittens; Dianne Cooper; S Headland; G Piras.
Visiting Scientists: A Amoruso; D Federici-Canova; I Locatelli (University of Novara, Italy); Dr MF Montero-Medeira (Belo Horizonte, Brazil).

Key Publications

Patel HB, Kornerup KN, Sampaio AL, D'Acquisto F, Seed MP, Girol AP, Gray M, Pitzalis C, Oliani SM, Perretti M. The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis. 2012 Nov;71(11):1872-80.

Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti M. Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1970-8.

Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M. Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2749-59.

Montero-Melendez T, Patel HB, Seed M, Nielsen S, Jonassen TE, Perretti M. The  melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties. Am J Pathol. 2011 Jul;179(1):259-69.

Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G, Perretti M. Evidence for  an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol. 2011 Apr 15;186(8):4905-14. doi: 10.4049/jimmunol.1003145.

Patel HB, Bombardieri M, Sampaio AL, D'Acquisto F, Gray M, Grieco P, Getting SJ, Pitzalis C, Perretti M. Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 2010 Dec;24(12):4835-43.

Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, D'Acquisto F, Buckingham JC, Perretti M, Flower RJ. Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol. 2010 Mar 1;184(5):2611-9.

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461(7268):1287-91.

Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY, Perretti M. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood. 2008 Sep 15;112(6):2512-9.

Hayhoe RP, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M. Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood. 2006 Mar 1;107(5):2123-30.

PubLists Publications

Sponsors

British Heart Foundation
Arthritis Uk
Wellcome Trust

Collaborators

Internal: Dr Michele Bombardieri; Dr FulvioD’Acquisto; Prof Federica Marelli-Berg; Dr Charles Hinds; Prof Sussan Nourshargh; Prof Cos Pitzalis; Dr Egle Solito; Prof Gleb Sukhorukov; Prof Chris Thiemermann; 
External: B Dasgupta (Southend University Hospital); S Farsky (USP, Sao Paulo, Brazil); J Mason (Imperial College); A Nusrat (Emory University, Atlanta); SM Oliani (UNESP, Sao José do Rio Preto, Brazil); C Reutelingsperger (Maastricht University); CN Serhan (Harvard Medical School, Boston); MM Teixeira (UNMG, Belo Horizonte, Brazil); N Vergnolle (INSERM, Toulouse); JL Wallace (McMaster University, Hamilton); V Witko-Sarsat (Cochin Hopital, Paris);
Industrial: N Mehta; A Consalvo (Unigene Corporation); T Jonassen (SynAct Pharma ApS, Aarhus); A Moore (UCB Celltech, Slough); D Taylor; A Kamal (MRC Technology, London).

Contact

Mauro Perretti, PhD, FBPharmacolS, FSB
Professor of Immunopharmacology
Deputy Director William Harvey Research Institute
Barts and The London School of Medicine
Queen Mary University of London
Charterhouse Square
London, EC1M 6BQ
T: +44 (0) 20 77882 5896
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PA: Miss Silvia Ayguade
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