Mauro Perretti

 Co-director of WHRI/Professor of Immunopharmacology

Mauro PerrettiMauro has published over 280 papers, with >11,000 citations and an H Factor of 60 (Google Scholar).
After BSc in Pharmaceutical Chemistry (University in Florence, 1985) and a MSc in Pharmacology and Toxicology (1988), Mauro started his career at the Sclavo Research Centre under the leadership of Prof Luca Parente. In 1991 he joined Prof Rod Flower at the William Harvey Research Institute, and in 1996 he gained his PhD (LON).
Mauro career has been shaped by fellowships from the Arthritis Research Campaign, a post-doctoral one (1997-2002) followed by a senior fellowship (2002-2007). In 2001 Mauro gained his personal chair by Queen Mary University of London; in 2011 he took the Leadership of the Centre for Biochemical Pharmacology, with Prof Marelli-Berg as Deputy.  Since 2006 he acts as Deputy Director of the William Harvey Research Institute, a role he still carries on. 
Mauro is Fellow of the British Pharmacological Society (FBPharmacolS,  2004), of the Academia Europea (2010) and of the Society of Biology (2012).

Summary of Research

We pioneered the concept that acute inflammation resolves, naturally, by the engagement of endogenous mediators that activate a series of non-redundant processes (inhibition of immune cell trafficking, efferocytosis, tissue repair) typical of what we now call the Resolution of Inflammation. When resolution is malfunctioning it contributes to chronic inflammatory diseases. We study the pathophysiology of some pro-resolving pathways (eg. Annexin A1 and its peptides, Glucocorticoids+calcitonin, Melanocortins, omega-3 derivatives) and aim to identify novel receptors amenable for the development of innovative anti-inflammatory therapeutics. A current focus is on pro-resolving GPCRs, such as FPR2/ALX and MC3, establishing their expression in disease; homo/heterodimerization and discovering novel biological functions.
Molecular pharmacology and cell biology protocols are complemented by integrated biology models (intravital microscopy for vascular responses, peritonitis, paw oedema, airpouch) including models of disease (arthritis, myocardial infarct and stroke). Each project is different in its practicality since it is the scientific question that drives the experimental protocols to be applied or developed, hence creativity is a must!
We are acutely aware of the importance to assess the relevance of our research in clinical settings, as this would accelerate the development of innovative therapeutics modelled on resolution; currently the focus is on rheumatology, cardiac surgery, sepsis and vasculitides.

Expression of the pro-resolving receptor FPR2

Expression of the pro-resolving receptor FPR2 (a GPCR that transduces the actions of AnnexinA1 and Lipxin A4) as revealed by Green Florescence Protein detection, using a unique mouse colony  engineered with this reporter under FPR2 promoter (funded by The Wellcome Trust).

Microcapsules

Microcapsules (MC; green) can be used to deliver biologically active molecules to modulate the interaction between human leukocytes and the endothelium. (Collaboration with Prof Sukhorukov, QMUL).

Members of the Group

Research staff: Lucy Norling; T Gobbetti; M Kaneva; T Montero-Melendez; B Gittens; Dianne Cooper; Hefin R Jones, Patricia Souza; .
Visiting Scientists: AP Piovezan; F Mafra de Lima.

 

Key Publications

 Nadkarni S, Dalli J, Hollywood J, Mason JC, Dasgupta B, Perretti M.
Investigational analysis reveals a potential role for neutrophils in giant-cell
arteritis disease progression. Circ Res. 2014 Jan 17;114(2):242-8. doi:
10.1161/CIRCRESAHA.114.301374. Epub 2013 Oct 24. PubMed PMID: 24158630.

Cooray SN, Gobbetti T, Montero-Melendez T, McArthur S, Thompson D, Clark AJ, Flower RJ, Perretti M. Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18232-7. doi:10.1073/pnas.1308253110.  PMID: 24108355

  Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ,
Vergnolle N, Nourshargh S, Perretti M. A vasculo-protective circuit centered on
lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine
microcirculation. Blood. 2013 Jul 25;122(4):608-17. doi:
10.1182/blood-2013-04-496661. Epub 2013 Jun 3. PubMed PMID: 23733341; PubMed Central PMCID: PMC3724196

Patel HB, Kornerup KN, Sampaio AL, D'Acquisto F, Seed MP, Girol AP, Gray M,
Pitzalis C, Oliani SM, Perretti M. The impact of endogenous annexin A1 on
glucocorticoid control of inflammatory arthritis. Ann Rheum Dis. 2012
Nov;71(11):1872-80. doi: 10.1136/annrheumdis-2011-201180. Epub 2012 May 5. PubMed PMID: 22562975; PubMed Central PMCID: PMC3440300.

Dalli J, Norling LV, Renshaw D, Cooper D, Leung KY, Perretti M. Annexin 1
mediates the rapid anti-inflammatory effects of neutrophil-derived
microparticles. Blood. 2008 Sep 15;112(6):2512-9. doi:
10.1182/blood-2008-02-140533. Epub 2008 Jul 1. PubMed PMID: 18594025.

PubLists Publications

Thompson D, McArthur S, Hislop JN et al. (2014). Identification of a novel recycling sequence in the C-tail of FPR2/ALX: association with cell protection from apoptosis.. J Biol Chem Vol., () -.
10.1074/jbc.M114.612630
Gobbetti T, Ducheix S, le Faouder P et al. (2014). Protective effects of n-6 fatty acids-enriched diet on intestinal ischemia/reperfusion injury involve lipoxin A4 and its receptor.. Br J Pharmacol Vol., () -.
10.1111/bph.12957
Greco KV, Nalesso G, Kaneva MK et al. (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin.. Biochem Pharmacol Vol.91, (3) 348-358.
10.1016/j.bcp.2014.07.034
Brancaleone V, Mitidieri E, Flower RJ et al. (2014). Annexin A1 mediates hydrogen sulfide properties in the control of inflammation.. J Pharmacol Exp Ther Vol.351, (1) 96-104.
10.1124/jpet.114.217034
Machado ID, Santin JR, Drewes CC et al. (2014). Alterations in the profile of blood neutrophil membrane receptors caused by in vivo adrenocorticotrophic hormone actions.. Am J Physiol Endocrinol Metab Vol., () ajpendo.00227.2014-.
10.1152/ajpendo.00227.2014
Montero-Melendez T, Madeira MF, Norling LV et al. (2014). Association between periodontal disease and inflammatory arthritis reveals modulatory functions by melanocortin receptor type 3.. Am J Pathol Vol.184, (8) 2333-2341.
10.1016/j.ajpath.2014.04.009
Locatelli I, Sutti S, Jindal A et al. (2014). Endogenous Annexin A1 Is a Novel Protective Determinant in Nonalcoholic Steatohepatitis in Mice. HEPATOLOGY Vol.60, (2) 0270-9139 531-544.
10.1002/hep.27141
Montero-Melendez T, Perretti M (2014). Gapdh gene expression is modulated by inflammatory arthritis and is not suitable for qPCR normalization.. Inflammation Vol.37, (4) 1059-1069.
10.1007/s10753-014-9829-x
Ahmed TJ, Kaneva MK, Pitzalis C et al. (2014). Resolution of inflammation: examples of peptidergic players and pathways.. Drug Discov Today Vol.19, (8) 1166-1171.
10.1016/j.drudis.2014.05.020
Cash JL, Norling LV, Perretti M (2014). Resolution of inflammation: targeting GPCRs that interact with lipids and peptides.. Drug Discov Today Vol.19, (8) 1186-1192.
10.1016/j.drudis.2014.06.023
Montero-Melendez T, Perretti M (2014). Connections in pharmacology: innovation serving translational medicine.. Drug Discov Today Vol.19, (7) 820-823.
10.1016/j.drudis.2013.11.022
Old EA, Nadkarni S, Grist J et al. (2014). Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. JOURNAL OF CLINICAL INVESTIGATION Vol.124, (5) 0021-9738 2023-2036.
10.1172/JCI71389
Nadkarni S, Dalli J, Hollywood J et al. (2014). NEUTROPHILS IN GCA. RHEUMATOLOGY Vol.53, () 1462-0324 9-9.
Nadkarni S, Dalli J, Hollywood J et al. (2014). Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression.. Circ Res Vol.114, (2) 242-248.
10.1161/CIRCRESAHA.114.301374
Headland SE, Jones HR, D'Sa AS et al. (2014). Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry.. Sci Rep Vol.4, () 5237-.
10.1038/srep05237
Dalli J, Norling LV, Montero-Melendez T et al. (2014). Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis.. EMBO Mol Med Vol.6, (1) 27-42.
10.1002/emmm.201303503
Fu H, Kishore M, Gittens B et al. (2014). Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.. Nat Commun Vol.5, () 3436-.
10.1038/ncomms4436
Mathie SA, Bena S, Mondae M et al. (2013). Activation of annexin A1-FPR2 axis promotes resolution of house dust mite induced airway hyper-reactivity. IMMUNOLOGY Vol.140, () 0019-2805 82-83.
Cooray SN, Gobbetti T, Montero-Melendez T et al. (2013). Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses.. Proc Natl Acad Sci U S A Vol.110, (45) 18232-18237.
10.1073/pnas.1308253110
Cash JL, Bena S, Headland SE et al. (2013). Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23.. EMBO Rep Vol.14, (11) 999-1007.
10.1038/embor.2013.138
Brancaleone V, Flower RJ, Cirino G et al. (2013). Annexin A1 (AnxA1) mediates hydrogen sulfide (H2S) effects in the control of inflammation. NITRIC OXIDE-BIOLOGY AND CHEMISTRY Vol.31, () 1089-8603 S21-S22.
10.1016/j.niox.2013.06.036
Dalli J, Montero-Melendez T, Norling LV et al. (2013). Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties.. Mol Cell Proteomics Vol.12, (8) 2205-2219.
10.1074/mcp.M113.028589
Godson C, Perretti M (2013). Novel pathways in the yin-yang of immunomodulation. CURRENT OPINION IN PHARMACOLOGY Vol.13, (4) 1471-4892 543-546.
10.1016/j.coph.2013.06.010
Brancaleone V, Gobbetti T, Cenac N et al. (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.. Blood Vol.122, (4) 608-617.
10.1182/blood-2013-04-496661
Iqbal AJ, Cooper D, Vugler A et al. (2013). Endogenous galectin-1 exerts tonic inhibition on experimental arthritis.. J Immunol Vol.191, (1) 171-177.
10.4049/jimmunol.1203291
Dalli J, Consalvo AP, Ray V et al. (2013). Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor.. J Immunol Vol.190, (12) 6478-6487.
10.4049/jimmunol.1203000
Norling LV, Perretti M (2013). The role of omega-3 derived resolvins in arthritis.. Curr Opin Pharmacol Vol.13, (3) 476-481.
10.1016/j.coph.2013.02.003
Nusrat A, Leoni G, Neumann P-A et al. (2013). Annexin 1 in microparticles promotes intestinal mucosal wound repair during inflammation.. JOURNAL OF IMMUNOLOGY Vol.190, () 0022-1767 -.
Fowkes RC, Moradi-Bidhendi N, Branceleone V et al. (2013). Annexin-A1 protein and its relationship to cortisol in human saliva. PSYCHONEUROENDOCRINOLOGY Vol.38, (5) 0306-4530 722-727.
10.1016/j.psyneuen.2012.08.003
Ortega-Gomez A, Perretti M, Soehnlein O (2013). Resolution of inflammation: an integrated view. EMBO MOLECULAR MEDICINE Vol.5, (5) 1757-4676 661-674.
10.1002/emmm.201202382
Ryan SM, McMorrow J, Umerska A et al. (2013). An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis.. J Control Release Vol.167, (2) 120-129.
10.1016/j.jconrel.2013.01.027
Patel HB, Bombardieri M, Pitzalis C et al. (2013). Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis. FASEB JOURNAL Vol.27, () 0892-6638 -.
Cooray SN, Clark A, Flower R et al. (2013). Agonist-induced conformational change of the Formyl Peptide Receptors. FASEB JOURNAL Vol.27, () 0892-6638 -.
Thompson D, Perretti M (2013). Differential Trafficking of the FPR2/ALX receptor in response to endogenous or synthetic ligands. FASEB JOURNAL Vol.27, () 0892-6638 -.
Leoni G, Neumann P-A, Alam A et al. (2013). Epithelial wound repair: insights into the multifaceted roles of Annexin A1. FASEB JOURNAL Vol.27, () 0892-6638 -.
Montero-Melendez T, Dalli J, Perretti M (2013). Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors.. Cell Death Differ Vol.20, (4) 567-575.
10.1038/cdd.2012.154
Gittens B, Perretti M, Cooper D (2013). Investigating Novel Roles for Exogenous and Endogenous Galectin-3 in Controlling Vascular Inflammation. FASEB JOURNAL Vol.27, () 0892-6638 -.
Martin K, Perretti M, Ahluwalia A (2013). Kinin B1 receptor regulates inflammatory cell recruitment during low laminar shear stress. FASEB JOURNAL Vol.27, () 0892-6638 -.
Perretti M, Bena S, Brancaleone V et al. (2013). Modulation of the receptor ALX/FPR2 in vascular inflammation. FASEB JOURNAL Vol.27, () 0892-6638 -.
Perretti M, Dalli J, Norling LV et al. (2013). Neutrophil Microparticles are heterogenous in content and function. FASEB JOURNAL Vol.27, () 0892-6638 -.
Headland SE, Dell'Accio F, Perretti M (2013). Neutrophil-Derived Microparticles as Novel Effectors in Joint Disease. FASEB JOURNAL Vol.27, () 0892-6638 -.
Norling LV, Perretti M (2013). Omega-3 derived Resolvin D1 reduces the severity of inflammatory arthritis. FASEB JOURNAL Vol.27, () 0892-6638 -.
Poliselli Farsky SH, Machado ID, Santin JR et al. (2013). Role of cytosolic glucocorticoid receptor and Annexin-A1 on neutrophil traffic from bone marrow into blood: SDF-1alpha/CXCR-4/CXCR-2 axis. FASEB JOURNAL Vol.27, () 0892-6638 -.
Rhodes DH, Pini M, Castellanos KJ et al. (2013). Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function.. Obesity (Silver Spring) Vol.21, (2) 310-319.
10.1002/oby.20016
Leoni G, Alam A, Neumann P-A et al. (2013). Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. JOURNAL OF CLINICAL INVESTIGATION Vol.123, (1) 0021-9738 443-454.
10.1172/JCI65831
Kosicka A, Cunliffe AD, Mackenzie R et al. (2013). Attenuation of plasma annexin A1 in human obesity. FASEB JOURNAL Vol.27, (1) 0892-6638 368-378.
10.1096/fj.12-213728
Sampaio AL, Dalli J, Brancaleone V et al. (2013). Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression.. Mediators Inflamm Vol.2013, () 741804-.
10.1155/2013/741804
Schutters K, Kusters DH, Chatrou ML et al. (2013). Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells.. Cell Death Differ Vol.20, (1) 49-56.
10.1038/cdd.2012.107
Norling LV, Perretti M (2013). Control of myeloid cell trafficking in resolution.. J Innate Immun Vol.5, (4) 367-376.
10.1159/000350612
Ahmed TJ, Montero-Melendez T, Perretti M et al. (2013). Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides.. Int J Inflam Vol.2013, () 2090-8040 985815-.
10.1155/2013/985815
Montero-Meléndez T, Llor X, García-Planella E et al. (2013). Identification of novel predictor classifiers for inflammatory bowel disease by gene expression profiling.. PLoS One Vol.8, (10) e76235-.
10.1371/journal.pone.0076235
Pang J, Rhodes DH, Pini M et al. (2013). Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice.. PLoS One Vol.8, (2) e57915-.
10.1371/journal.pone.0057915
Viiri LE, Full LE, Navin TJ et al. (2013). Smooth muscle cells in human atherosclerosis: Proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Vol.54, () 0022-2828 65-72.
10.1016/j.yjmcc.2012.11.002
Al-Kashi A, Montero-Melendez T, Moradi-Bidhendi N et al. (2013). The calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritis.. PLoS One Vol.8, (2) e54299-.
10.1371/journal.pone.0054299
Patel HB, Kornerup KN, Sampaio AL et al. (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.. Ann Rheum Dis Vol.71, (11) 1872-1880.
10.1136/annrheumdis-2011-201180
Cardini S, Dalli J, Fineschi S et al. (2012). Genetic Ablation of the Fpr1 Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Vol.47, (3) 1044-1549 332-339.
10.1165/rcmb.2012-0036OC
Perretti M (2012). Editorial: to resolve or not to resolve: annexin A1 pushes resolution on track.. J Leukoc Biol Vol.92, (2) 245-247.
10.1189/jlb.0312128
Headland S, Perretti M (2012). Neutrophil microparticles as novel effectors of joint disease. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.93, (4) 0959-9673 A30-A30.
Norling LV, Dalli J, Flower RJ et al. (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.. Arterioscler Thromb Vasc Biol Vol.32, (8) 1970-1978.
10.1161/ATVBAHA.112.249508
Bena S, Brancaleone V, Wang JM et al. (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.. J Biol Chem Vol.287, (29) 24690-24697.
10.1074/jbc.M112.377101
Kabouridis PS, Pimentel TA, Brancaleone V et al. (2012). Distinct localization of T cell Agrin during antigen presentation--evidence for the expression of Agrin receptor(s) in antigen-presenting cells.. FEBS J Vol.279, (13) 2368-2380.
10.1111/j.1742-4658.2012.08615.x
Vong L, Ferraz JGP, Dufton N et al. (2012). Up-Regulation of Annexin-A1 and Lipoxin A(4) in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis. PLOS ONE Vol.7, (6) 1932-6203 -.
10.1371/journal.pone.0039244
Clark AK, Grist J, Al-Kashi A et al. (2012). Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. ARTHRITIS AND RHEUMATISM Vol.64, (6) 0004-3591 2038-2047.
10.1002/art.34351
Leinster DA, Kulbe H, Everitt G et al. (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer.. J Pathol Vol.227, (2) 136-145.
10.1002/path.4002
Liverani E, Banerjee S, Roberts W et al. (2012). Prednisolone exerts exquisite inhibitory properties on platelet functions.. Biochem Pharmacol Vol.83, (10) 1364-1373.
10.1016/j.bcp.2012.02.006
Headland SE, Perretti M (2012). NEUTROPHIL MICROPARTICLES AS POTENTIAL NOVEL EFFECTORS OF JOINT DISEASE. RHEUMATOLOGY Vol.51, () 1462-0324 47-47.
Norling L, Dalli J, Flower R et al. (2012). RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS. RHEUMATOLOGY Vol.51, () 1462-0324 47-48.
Cooper D, Iqbal AJ, Gittens BR et al. (2012). The effect of galectins on leukocyte trafficking in inflammation: sweet or sour?. Ann N Y Acad Sci Vol.1253, () 181-192.
10.1111/j.1749-6632.2011.06291.x
Colom B, Poitelon Y, Huang W et al. (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.. FASEB J Vol.26, (3) 1064-1076.
10.1096/fj.11-196220
Di Filippo C, Perretti M, Rossi F et al. (2012). Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol.385, (2) 0028-1298 137-144.
10.1007/s00210-011-0703-1
de Lima CB, Tamura EK, Montero-Melendez T et al. (2012). Actions of translocator protein ligands on neutrophil adhesion and motility induced by G-protein coupled receptor signaling.. Biochem Biophys Res Commun Vol.417, (2) 918-923.
10.1016/j.bbrc.2011.12.078
Dalli J, Montero-Melendez T, McArthur S et al. (2012). Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.. Front Pharmacol Vol.3, () 28-.
10.3389/fphar.2012.00028
Dalli J, Jones CP, Cavalcanti DM et al. (2012). Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow.. FASEB J Vol.26, (1) 387-396.
10.1096/fj.11-182089
Vessillier S, Adams G, Montero-Melendez T et al. (2012). Molecular engineering of short half-life small peptides (VIP, αMSH and γ₃MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics.. Ann Rheum Dis Vol.71, (1) 143-149.
10.1136/annrheumdis-2011-200100
Greco KV, Iqbal AJ, Rattazzi L et al. (2011). High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents.. Biochem Pharmacol Vol.82, (12) 1919-1929.
10.1016/j.bcp.2011.09.009
Nadkarni S, Cooper D, Brancaleone V et al. (2011). Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes.. Arterioscler Thromb Vasc Biol Vol.31, (11) 2749-2759.
10.1161/ATVBAHA.111.235176
Nadkarni S, Hollywood J, Mason JC et al. (2011). Annexin-A1: A Potential Novel Biomarker in Giant Cell Arteritis.. ARTHRITIS AND RHEUMATISM Vol.63, (10) 0004-3591 S593-S593.
Montero-Melendez T, Patel HB, Seed M et al. (2011). The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties.. Am J Pathol Vol.179, (1) 259-269.
10.1016/j.ajpath.2011.03.042
Greco KV, Moore A, Dell'Accio F et al. (2011). 3D CULTURES OF C-28/I2 CHONDROCYTES TO STUDY CHONDROCYTE BIOLOGY AND THERAPEUTIC DEVELOPMENT. INFLAMMATION RESEARCH Vol.60, () 1023-3830 283-283.
Brancaleone V, Sampaio AL, Cirino G et al. (2011). A NOVEL CROSS-TALK IN RESOLUTION: H2S ACTIVATES THE ANNEXIN A1 PATHWAY. INFLAMMATION RESEARCH Vol.60, () 1023-3830 291-293.
Iqbal AJ, Cooper D, Vugler AD et al. (2011). ENDOGENOUS GALECTIN-1 INHIBITS EXPERIMENTAL ARTHRITIS: A POTENTIAL SWEET THERAPEUTIC TARGET?. INFLAMMATION RESEARCH Vol.60, () 1023-3830 186-187.
Rhodes D, Pini M, Montero-Melendez T et al. (2011). EXPRESSION OF ANNEXIN A1 IN ADIPOSE TISSUE IS DISSOCIATED FROM MACROPHAGE INFILTRATION DURING DEVELOPMENT OF OBESITY IN MICE. INFLAMMATION RESEARCH Vol.60, () 1023-3830 261-261.
Cooper D, Iqbal AJ, Niki T et al. (2011). GALECTIN-9: SWEETENING LEUKOCYTE RECRUITMENT. INFLAMMATION RESEARCH Vol.60, () 1023-3830 87-88.
Perretti M (2011). GLUCOCORTICOIDS CUT SHORT THE CONCERT OF INFLAMMATION THROUGH THE RELEASE OF ANNEXIN A1. INFLAMMATION RESEARCH Vol.60, () 1023-3830 16-17.
Montero-Melendez T, Jonassen T, Seed M et al. (2011). MC3 AGONISTS AS NOVEL PRO-RESOLVING THERAPEUTICS. INFLAMMATION RESEARCH Vol.60, () 1023-3830 269-269.
Greco KV, Montero-Melendez T, Patel H et al. (2011). MELANOCORTIN RECEPTOR AGONISTS ARE NOVEL CHONDROPROTECTIVE THERAPEUTICS. INFLAMMATION RESEARCH Vol.60, () 1023-3830 273-273.
Vessillier S, Adams G, Montero-Melendez T et al. (2011). MOLECULAR ENGINEERING OF SHORT HALF LIFE SMALL PEPTIDES (VIP, alpha MSH AND gamma 3MSH) INTO LATENT ASSOCIATED PEPTIDE (LAP) RESULTS IN TARGETED ANTI-INFLAMMATORY AND ANTI-RHEUMATIC THERAPEUTICS. INFLAMMATION RESEARCH Vol.60, () 1023-3830 43-43.
Norling LV, Dalli J, Serhan CN et al. (2011). RESOLVIN D1 LIMITS PMN RECRUITMENT TO INFLAMMATORY LOCI: RECEPTOR DEPENDENT BIOACTIONS. INFLAMMATION RESEARCH Vol.60, () 1023-3830 60-60.
Roviezzo F, Brancaleone V, De Gruttola L et al. (2011). Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.. J Pharmacol Exp Ther Vol.337, (3) 830-837.
10.1124/jpet.111.179168
Maione F, Cicala C, Liverani E et al. (2011). IL-17A increases ADP-induced platelet aggregation.. Biochem Biophys Res Commun Vol.408, (4) 658-662.
10.1016/j.bbrc.2011.04.080
Norling LV, Spite M, Yang R et al. (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J IMMUNOL Vol.186, (10) 0022-1767 5543-5547.
10.4049/jimmunol.1003865
Velmurugan S, Kapil V, McKnight AHO et al. (2011). Dietary nitrate attenuates platelet reactivity: Role of the erythrocyte and influence of sex. NITRIC OXIDE-BIOLOGY AND CHEMISTRY Vol.24, () 1089-8603 S35-S36.
10.1016/j.niox.2011.03.285
Villar IC, Scotland RS, Khambata RS et al. (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin.. Arterioscler Thromb Vasc Biol Vol.31, (5) 1075-1083.
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Perretti M, D'Acquisto F, Flower RJ (). Treatment. Vol., () -.

Sponsors

British Heart Foundation
Arthritis Uk
Wellcome Trust

Collaborators

Internal: Dr Michele Bombardieri; Dr FulvioD’Acquisto; Prof Federica Marelli-Berg; Dr Charles Hinds; Prof Sussan Nourshargh; Prof Cos Pitzalis; Dr Egle Solito; Prof Gleb Sukhorukov; Prof Chris Thiemermann; 
External: B Dasgupta (Southend University Hospital); S Farsky (USP, Sao Paulo, Brazil); J Mason (Imperial College); A Nusrat (Emory University, Atlanta); SM Oliani (UNESP, Sao José do Rio Preto, Brazil); C Reutelingsperger (Maastricht University); CN Serhan (Harvard Medical School, Boston); MM Teixeira (UNMG, Belo Horizonte, Brazil); N Vergnolle (INSERM, Toulouse); JL Wallace (McMaster University, Hamilton); V Witko-Sarsat (Cochin Hopital, Paris);
Industrial: N Mehta; A Consalvo (Unigene Corporation); T Jonassen (SynAct Pharma ApS, Aarhus); A Moore (UCB Celltech, Slough); D Taylor; A Kamal (MRC Technology, London).

Contact

Mauro Perretti, PhD, FBPharmacolS, FSB
Professor of Immunopharmacology
Co-Director William Harvey Research Institute
Barts and The London School of Medicine
Queen Mary University of London
Charterhouse Square
London, EC1M 6BQ
T: +44 (0) 20 77882 8782 
E:   This email address is being protected from spambots. You need JavaScript enabled to view it.

PA: Miss Silvia Ayguade
T: +44 (0) 20 77882 8783 E:  This email address is being protected from spambots. You need JavaScript enabled to view it.

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