Adult Critical Care Unit
Dr O’Dwyer graduated from medical school at Trinity College, Dublin, Ireland in 1998 and then subsequently trained and specialised as an anaesthetist. In 2008 he acquired his PhD, again from Trinity College, which explored the innate and adaptive immune response to human infection and critical illness. He also developed a research interest in high altitude physiology and was a member of the 2007 xtreme everest expedition acquiring arterial blood samples from the summit of Mt Everest. A further period of clinical training led to a second specialisation as an intensive care medicine physician in Australia. Following this, he was appointed in 2012 as a Senior Lecturer in Intensive Care Medicine at QMUL and an honorary ICU consultant at The Royal London Hospital.
Summary of Research
- Immunological, genetic and epigenetic factors in the susceptibility to develop hospital-acquired infections in critically ill patients
- T cell maturation and the susceptibility to develop hospital-acquired infections following elective major surgery
- Gene expression following uneventful cardiac surgery
- Inflammatory and immune mediators in high altitude performance.
Members of the Group
Research staff: Helen Owen, Hew Torrance, Rebecca Longbottom, James O'Carroll
For a full list of publist publications click here
Torrance HDT, Vivian M, Brohi K, Pearse RM, Owen HC, Hinds CJ, O’Dwyer MJ. The duration of storage of packed red blood cells prior to transfusion is associated with a characteristic gene expression pattern. J Trauma Acute Care Surg. 2014 In press.
Fragou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O’Dwyer MJ. Perioperative blood transfusion is assocaited with a gene transcription profile characteristic of immunosuppression: a prospective cohort study. Crit Care 2014. Oct 1;18(5):541
Torrance HDT, Brohi K, Pearse R, Mein CA, Wozniak E, Prowle JR, Hinds CJ, O’Dwyer MJ. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Ann Surg 2014 Mar 25.