Costantino Pitzalis

Costantino Pitzalis

 Head of Centre for Experimental Medicine & Rheumatology

Costantino Pitzalis is Professor of Experimental Medicine and Rheumatology and Head of the Centre for Experimental Medicine and Rheumatology. His clinical interests encompass general rheumatology with a focus on immune/inflammatory rheumatic diseases, including rheumatoid and psoriatic arthritis.

His major research interests focus on the cellular and molecular mechanisms of inflammation and autoimmunity in chronic arthritis with particular emphasis on translational research and biomarkers discovery. He leads a Research Team of over 35 Researchers (Clinicians and Scientists) with more than £11million research income. He has produced research of international standing captured in over 140 publications (over 50 in journals with impact factor >5) in the field of inflammation, immunity and arthritis.

Professor Pitzalis serves on the EULAR Scientific Committee and the Heberden Committee, British Society for Rheumatology. He is a member of the Research Grant Committee Arthritis Research UK and several other national and international committees. He serves on the Editorial Board of Annals of Rheumatic Diseases and Arthritis Research & Therapy.

Summary of Research

The mission is to better understand disease pathogenesis in order to develop novel therapeutics and maximise therapeutic utility of existing therapies. The ultimate goal is to find a cure for rheumatoid and osteo arthritis.

To achieve this goal the Centre focuses on a strong basic science programme in the field of immunology & inflammation linked to a clinical translational programme in the following 4 research areas:

  1. Breach of Tolerance & Autoimmunity
    In this area our effort focus on: a) Investigating development of T/B cell autoimmunity in secondary- vs tertiary-lymphoid-structures and in early vs established RA (Bombardieri / Pitzalis); b) Role of FDCs and RASF in auto-antigen retention and breach of B cell tolerance (ElShikh / Pitzalis) and c) analysis of the antigenic specificities of lesional T and B cells (Bombardieri / Pitzalis).

  2. Development and resolution of inflammation & Mechanisms of Tissue Damage and Repair
    In this area our effort focus on: a) Mechanisms of T and B cell recruitment and retention using in vivo models (eg. RA/SCID/)(Bombardieri/Pitzalis); b) Resolution-of-inflammation through endogenous anti-inflammatory pathway. This area is investigated / developed through a long-standing collaboration with Prof Perretti and c) Mechanisms of Tissue Damage and Repair with particular emphasis on cartilage homeostasis. This research area is particular competence of Professor Dell’Accio.

  3. Developing new therapies through understanding of pathogenesis
    The Centre is actively involved in the development of novel therapeutics both through its own drug development programme (e.g. developing single chain (sc)Fv antibodies, identified by phage display technology, to specifically target joint tissues) and, in collaboration with industry, via the progression of the pharma pipeline. The Centre has been awarded an ARUK-Experimental-Arthritis-Treatment-Centres and is part of the National-Institute-for-Health-Research Translational-Research-Partnership.

  4. Patients stratification to understand pathogenesis of disease evolution and response to therapy
    (Kelly/Humby/Barnes/Bombardieri/Sassieni/Pitzalis). The Centre builds on an existing large biomarker discovery and clinical trial programme to identify specific synovial tissue-driven bio-variables and blood correlates of clinical evolution and response to therapy. These include MRC/PEAC, MRC/ABPI and NIHR-EME initiatives. In addition, the ability of targeted biologics (TNF/IL6R/B-cell blockade) to modulate the panoply of RA associated immune abnormalities will be utilized to better understand and dissect the complex immunological networks in the disease tissue in patients with RA.

Training: To ensure the next generation of Doctors and Scientists is available to translate scientific discoveries into medicine for patient benefit, the Centre provides high quality research training in musculoskeletal basic and translational sciences. The Centre has a highly successful training record and is a recipient of two PhD programmes: a) an Oliver Bird Rheumatism Nuffield Foundation Programme and b) an Arthritis Research UK Clinical PhD Programme.

Through these programmes the Centre provides academic training for Specialist Registrars over and above excellent clinical training to include the use of musculoskeletal ultrasound (US) in the management of rheumatic conditions. In addition, as part of the MRC-funded Pathobiology of Early Arthritis Cohort (PEAC), the Centre provides national / international training in US-guided, minimally invasive, synovial biopsy. The Centre has pioneered the use of this procedure in the UK, which has made possible to incorporate synovial pathobiology in MRC and NIHR clinical trials based on tissue-driven patient stratification.  

Rheumatoid Arthritis

Members of the Group

Senior staff: Professor Francesco Dell'Accio; Dr Michele Bombardieri; Dr Mohey El Shikh; Dr Frances Humby; Dr Stephen Kelly

Research Staff: Dr Rebecca Hands; Dr William Murray-Brown; Dr Giovanna Nalesso; Dr Jo Sherwood; Mrs Sudeh Riahi; Dr Vidalba Rocher; Dr Emanuela Carlotti; Dr Elisa Corsiero; Dr Yvonne Kam;  Dr Sofia Grigoriadou; Dr Alessandra Nerviani; Dr Arti Mahto; Dr Maria Di Cicco; Mrs Celia Breston; Miss Victoria Katsande; Miss Audrey Davidson; Mrs Sandra Martins; Miss Suzanne Eldridge; Mr Mathieu Ferarri; Mr Davide Lucchesi; Dr Botan Nury; Miss Bethan Thomas

Support staff: Mrs Janice Haycocks; Mr Vladan Petrovic; Miss Laura White; Dr James Floyd; Dr Lu Zou; Mr Richard Meader, Miss Lauren Coombes; Mr Shannon Hyde.

Key Publications

Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide. Wythe SE, Dicara D, Taher TE, Finucane CM, Jones R, Bombardieri M, Man YK, Nissim A, Mather SJ, Chernajovsky Y, Pitzalis C. Ann Rheum Dis. 2012 Jul 27. PMID: 22843486

Kamperidis P, Kamalati T, Ferrari M, Jones M, Garrood T, Smith MD, Diez-Posada S, Hughes C, Finucane C, Mather S, Nissim A, George AJ, Pitzalis C.  Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis.  Arthritis Rheum. 2011 Dec;63(12):3758-67. doi: 10.1002/art.30650.  PMID: 21953304

Bombardieri M, Kam NW, Brentano F, Choi K, Filer A, Kyburz D, McInnes IB, Gay S, Buckley C, Pitzalis C.  A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells.  Ann Rheum Dis. 2011 Oct;70(10):1857-65. Epub 2011 Jul 27.  PMID: 21798884

Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'accio F. WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol. 2011 May 2; 193 (3):551-64.

Manzo A, Bombardieri M, Humby F, Pitzalis C. Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. Immunol Rev. 2010 Jan;233(1):267-85. Review.  PMID: 20193005

Humby F, Bombardieri M, Manzo A, Kelly S, Blades M ,Kirkham B, Spencer J and Pitzalis C. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med. 2009 Jan 13;6(1)  PMID: 19143467

Barone F, Bombardieri M, Rosado M M, Morgan P R, Challacombe S J , De Vita S, Carsetti R, Spencer J, Valesini G and Pitzalis C. CXCL13, CCL21 and CXCL12 expression in salivary glands of patients with Sjogren’s Syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol. 2008 Apr 1;180(7):5130-40

Manzo A, Bugatti S, Caporali R, Prevo R, Jackson D.G, Uguccioni M, Buckley C.D, Montecucco C, Pitzalis C. CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. Am J Pathol. Am J Pathol. 2007 Nov;171(5):1549-62.

Bombardieri M, Barone F, Humby F, Kelly S, McGurk M, Morgan P, Valesini V, Challacombe S, Spencer J and Pitzalis C. Activation-induced cytidine deaminase expression in germinal centers and large interfollicular B cells supports functionality of ectopic lymphoid neogenesis in reactive and neoplastic salivary glands of Sjogren’s syndrome. J Immunol. 2007 Oct 1;179(7):4929-4938).

Pitzalis C, Garrood T. From ubiquitous antigens to joint-specific inflammation: could local vascular permeability be the missing link? Trends Immunol. 2006 Jul;27(7):299-302.

Serena Bugatti, Roberto Caporali, Antonio Manzo, Barbara Vitolo, Costantino Pitzalis Carlomaurizio Montecucco. Subchondral bone marrow inflammatory involvement in rheumatoid arthritis: lymphoid neogenesis and in situ relationship with subchondral bone marrow osteoclasts. Arthritis Rheum. 2005 Nov;52(11):3448-59

Andrew JT George, Lewis Lee and Costantino Pitzalis.  Isolating ligands specific for human vasculature using in vivo phage selection. Trends in Biotechnology 2003 21 (5) 199-203.

L. Lee, C. Buckley, M.C. Blades, G. Panayi, A. George and C. Pitzalis. Identification of synovial specific homing peptides by in vivo phage display selection. Arthritis & Rheumatism, (2002) 46: 2109-2120

MC Blades, F Ingegnoli, A Manzo, SK Wheller, G Panayi, DO Haskard, M Perretti, and C Pitzalis. Stromal cell derived factor-1 (CXCL12) induces cell migration into lymph nodes transplanted into SCID mice. J Immunol (2002) 168: 4308-4317

 

For all publist publications for Professor Pitzalis click here

PubLists Publications

Genovese MC, Fleischmann R, Furst D et al. (2014). Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study.. Ann Rheum Dis Vol.73, (9) 1607-1615.
10.1136/annrheumdis-2013-204760
Croia C, Astorri E, Murray-Brown W et al. (2014). Implication of Epstein-Barr Virus Infection in Disease-Specific Autoreactive B Cell Activation in Ectopic Lymphoid Structures of Sjögren's Syndrome.. Arthritis Rheumatol Vol.66, (9) 2545-2557.
10.1002/art.38726
Sherwood J, Bertrand J, Nalesso G et al. (2014). A homeostatic function of CXCR2 signalling in articular cartilage.. Ann Rheum Dis Vol., () -.
10.1136/annrheumdis-2014-205546
Pitzalis C (2014). Pathogenesis of rheumatoid arthritis: from systemic autoimmunity to localised joint disease.. Drug Discov Today Vol.19, (8) 1152-1154.
10.1016/j.drudis.2014.05.009
Corsiero E, Pitzalis C, Bombardieri M (2014). Peripheral and synovial mechanisms of humoral autoimmunity in rheumatoid arthritis.. Drug Discov Today Vol.19, (8) 1161-1165.
10.1016/j.drudis.2014.05.017
Ahmed TJ, Kaneva MK, Pitzalis C et al. (2014). Resolution of inflammation: examples of peptidergic players and pathways.. Drug Discov Today Vol.19, (8) 1166-1171.
10.1016/j.drudis.2014.05.020
Pitzalis C, Jones GW, Bombardieri M et al. (2014). Ectopic lymphoid-like structures in infection, cancer and autoimmunity.. Nat Rev Immunol Vol.14, (7) 447-462.
10.1038/nri3700
Eldridge S, Vicente-Greco K, Nalesso G et al. (2014). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.95, (3) 0959-9673 A8-A9.
Nalesso G, Thomas B, Wagner K et al. (2014). The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.95, (3) 0959-9673 A25-A26.
Juarez M, Toms TE, de Pablo P et al. (2014). Comparison of Composite Measures of Disease Activity in Psoriatic Arthritis Using Data From an Interventional Study With Golimumab. ARTHRITIS CARE & RESEARCH Vol.66, (5) 2151-464X 757-764.
10.1002/acr.22204
Bugatti S, Manzo A, Vitolo B et al. (2014). High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease.. Rheumatology (Oxford) Vol., () -.
10.1093/rheumatology/keu163
Lucchesi D, Pitzalis C, Bombardieri M (2014). EBV and other viruses as triggers of tertiary lymphoid structures in primary Sjögren's syndrome.. Expert Rev Clin Immunol Vol.10, (4) 445-455.
10.1586/1744666X.2014.892417
Nalesso G, Thomas BL, Sherwood J et al. (2014). WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS. OSTEOARTHRITIS AND CARTILAGE Vol.22, () 1063-4584 S8-S9.
Thomas BL, Nalesso G, Sherwood J et al. (2014). WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE. OSTEOARTHRITIS AND CARTILAGE Vol.22, () 1063-4584 S160-S160.
Brown S, Coy NN, Pitzalis C et al. (2014). The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjogren's Syndrome. BMC MUSCULOSKELETAL DISORDERS Vol.15, () 1471-2474 -.
10.1186/1471-2474-15-21
El Shikh ME, Kmieciak M, Manjili MH et al. (2013). Multi-therapeutic potential of autoantibodies induced by immune complexes trapped on follicular dendritic cells.. Hum Vaccin Immunother Vol.9, (11) 2434-2444.
10.4161/hv.25596
Ferrari M, Onuoha S, Kamalati T et al. (2013). Development Of a Novel Bispecific Therapeutic For Arthritic Diseases. ARTHRITIS AND RHEUMATISM Vol.65, () 0004-3591 S218-S218.
Murray-Brown W, Croia C, Sutcliffe N et al. (2013). Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren's Syndrome. ARTHRITIS AND RHEUMATISM Vol.65, () 0004-3591 S634-S634.
Corsiero E, Bombardieri M, Carlotti E et al. (2013). Recombinant Monoclonal Antibodies Derived From Single CD19+Synovial B Cells Of RA Patients With Tertiary Lymphoid Structures Display a Strong Immunoreactivity Towards Citrullinated Histones. ARTHRITIS AND RHEUMATISM Vol.65, () 0004-3591 S1127-S1128.
Kam YNW, Filer A, Buckley CD et al. (2013). Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models. ARTHRITIS AND RHEUMATISM Vol.65, () 0004-3591 S1029-S1029.
Di Cicco M, Kelly S, Humby F et al. (2013). Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM Vol.65, () 0004-3591 S556-S556.
Croia C, Serafini B, Bombardieri M et al. (2013). Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis.. Ann Rheum Dis Vol.72, (9) 1559-1568.
10.1136/annrheumdis-2012-202352
Jones GW, Bombardieri M, Greenhill CJ et al. (2013). Interleukin-27 as a novel antagonist of ectopic lymphoid-like structure development in early inflammatory arthritis. CYTOKINE Vol.63, (3) 1043-4666 274-274.
10.1016/j.cyto.2013.06.137
Corsiero E, Sutcliffe N, Wardemann H et al. (2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEAL DEFECTS OF EARLY B CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 792-792.
Croia C, Serafini B, Tappuni A et al. (2013). ECTOPIC LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN SJOGREN'S SYNDROME SALIVARY GLANDS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 462-462.
Nayar S, Cloake T, Lane P et al. (2013). IL-22 REGULATES LYMPHOID STROMAL CELL EXPANSION, DEVELOPMENT OF GERMINAL CENTERS AND HUMORAL RESPONSE IN MUCOSAL ECTOPIC LYMPHONEOGENESIS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 140-140.
Murray-Brown W, Croia C, Sutcliffe N et al. (2013). LESIONAL IL-21 EXPRESSION CORRELATES WITH FUNCTIONAL GERMINAL CENTER FORMATION AND T FOLLICULAR HELPER CELL INFILTRATION IN THE SALIVARY GLANDS OF SJOGREN'S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 77-77.
Ng W-F, Miller A, Bowman S et al. (2013). LEVEL OF PHYSICAL ACTIVITY IN PRIMARY SJOGREN'S SYNDROME AND ITS PREDICTORS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 483-484.
Ng N, Di Cicco M, Humby F et al. (2013). MINIMALLY INVASIVE ULTRASOUND GUIDED SYNOVIAL BIOPSY AS A CLINICAL DIAGNOSTIC TOOL. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 1015-1016.
Ng N, Humby F, Kelly S et al. (2013). RHEUMATOID ARTHRITIS PATIENT CHARACTERISTICS AT DIFFERENT THERAPEUTIC TIMEPOINTS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 862-862.
Di Cicco M, Dadoun S, Humby F et al. (2013). SYNOVIAL ECTOPIC LYMPHOID-LIKE STRUCTURES ARE ASSOCIATED WITH DIAGNOSIS OF RHEUMATOID ARTHRITIS, DISEASE ACTIVITY AND ANTIBODY STATUS IN EARLY ARTHRITIS PATIENTS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 192-192.
Deidda S, Humby F, Kelly S et al. (2013). SYNOVIAL SUBLINING MACROPHAGES: A SENSITIVE BIOMARKER FOR RESPONSE TO TREATMENT IN EARLY RA PATIENTS.. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 583-584.
Pitzalis C, Kelly S, Humby F (2013). New learnings on the pathophysiology of RA from synovial biopsies.. Curr Opin Rheumatol Vol.25, (3) 334-344.
10.1097/BOR.0b013e32835fd8eb
Corsiero E, Sutcliffe N, Wardemann H et al. (2013). ACCUMULATION OF CIRCULATING AUTOREACTIVE NAIVE B CELLS REVEALS DEFECTS OF EARLY B-CELL TOLERANCE CHECKPOINTS IN PATIENTS WITH SJOGREN'S SYNDROME. RHEUMATOLOGY Vol.52, () 1462-0324 159-159.
Patel HB, Bombardieri M, Pitzalis C et al. (2013). Activation of Melanocortin Receptor 3 as a new strategy to control experimental and rheumatoid arthritis. FASEB JOURNAL Vol.27, () 0892-6638 -.
Ng N, Humby F, Bombardieri M et al. (2013). CLINICAL, IMAGING AND HISTOLOGICAL CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AT DIFFERENT STAGES OF DISEASE PROGRESSION. RHEUMATOLOGY Vol.52, () 1462-0324 71-71.
Kam NW, Filter A, Buckley C et al. (2013). MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION. RHEUMATOLOGY Vol.52, () 1462-0324 80-80.
Di Cicco M, Humby F, Kelly S et al. (2013). SYNOVIAL LYMPHOCYTE AGGREGATES IN EARLY INFLAMMATORY ARTHRITIS: CORRELATION WITH DIAGNOSIS, DISEASE ACTIVITY AND ANTIBODY STATUS. RHEUMATOLOGY Vol.52, () 1462-0324 29-29.
Sherwood J, Bertrand J, Nalesso G et al. (2013). THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS. OSTEOARTHRITIS AND CARTILAGE Vol.21, () 1063-4584 S19-S20.
Nalesso G, Thomas BL, Eldridge SE et al. (2013). WNT5A/CAMKII PATHWAY IS ACTIVATED IN OSTEOARTHRITIS AND PROMOTES LOSS OF CHONDROCYTE PHENOTYPE. OSTEOARTHRITIS AND CARTILAGE Vol.21, () 1063-4584 S226-S226.
Corsiero E, Sutcliffe N, Wardemann H et al. (2013). Accumulation of Circulating Autoreactive Naive B Cells Reveal Defects of Early B Cell Tolerance Checkpoints in Patients with Sjogren's Syndrome. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 A30-A31.
Lucchesi D, Bombardieri M, Barone F et al. (2013). INDUCIBLE TERTIARY LYMPHOID STRUCTURES AND AUTOIMMUNITY IN A NOVEL MODEL OF SIALOADENITIS IN WILD-TYPE MICE. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 A42-A42.
10.1136/annrheumdis-2013-203220.2
Kam NW, Filer A, Buckley C et al. (2013). MEMBRANE-BOUND AND SOLUBLE BAFF EXPRESSION BY HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES IN RESPONSE TO TLR STIMULATION. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 A38-A38.
10.1136/annrheumdis-2013-203219.22
Croia C, Serafini B, Bombardieri M et al. (2013). SYNOVIAL LYMPHOID STRUCTURES SUPPORT EPSTEIN-BARR VIRUS PERSISTENCE AND AUTOREACTIVE PLASMA CELL INFECTION IN RHEUMATOID ARTHRITIS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 A43-A44.
10.1136/annrheumdis-2013-203220.5
Sherwood J, Bertrand J, Nalesso G et al. (2013). THE ROLE OF CXCR2 SIGNALLING IN ARTICULAR CARTILAGE HOMEOSTASIS. ANNALS OF THE RHEUMATIC DISEASES Vol.72, () 0003-4967 A63-A64.
10.1136/annrheumdis-2013-203222.17
Sherwood J, Nalesso G, Bertrand J et al. (2013). A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.94, (1) 0959-9673 A7-A8.
Ahmed TJ, Montero-Melendez T, Perretti M et al. (2013). Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides.. Int J Inflam Vol.2013, () 2090-8040 985815-.
10.1155/2013/985815
Lendrem D, Mitchell S, McMeekin P et al. (2013). Health-related utility values of patients with primary Sjögren's syndrome and its predictors. Annals of the Rheumatic Diseases Vol., () 0003-4967 -.
10.1136/annrheumdis-2012-202863
Wythe SE, DiCara D, Taher TE et al. (2013). Targeted delivery of cytokine therapy to rheumatoid tissue by a synovial targeting peptide.. Ann Rheum Dis Vol.72, (1) 129-135.
10.1136/annrheumdis-2012-201457
Newton JL, Frith J, Powell D et al. (2012). Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome. ANNALS OF THE RHEUMATIC DISEASES Vol.71, (12) 0003-4967 1973-1979.
10.1136/annrheumdis-2011-201009
Patel HB, Kornerup KN, Sampaio AL et al. (2012). The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.. Ann Rheum Dis Vol.71, (11) 1872-1880.
10.1136/annrheumdis-2011-201180
Coates LC, Aslam T, Burden AD et al. (2012). Comparison of Three Screening Tools in Psoriatic Arthritis: The Contest Study.. ARTHRITIS AND RHEUMATISM Vol.64, (10) 0004-3591 S580-S580.
Scheinberg M, Filippi RZ, Hands R et al. (2012). Failure to Control Progression of Rheumatoid Arthritis After a Decade of Biologic Therapy. JOURNAL OF RHEUMATOLOGY Vol.39, (10) 0315-162X 2049-2051.
10.3899/jrheum.120385
Bombardieri M, Barone F, Lucchesi D et al. (2012). Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice.. J Immunol Vol.189, (7) 3767-3776.
10.4049/jimmunol.1201216
Corsiero E, Sutcliffe N, Wardemann H et al. (2012). Accumulation of circulating autoreactive naive B cells reveal defects of early B cell tolerance checkpoints in patients with Sjogren's syndrome. IMMUNOLOGY Vol.137, () 0019-2805 327-327.
Jones GW, Greenhill CJ, Williams AS et al. (2012). IL-27 control of ectopic lymphoid structures in inflammatory arthritis. IMMUNOLOGY Vol.137, () 0019-2805 44-44.
Lucchesi D, Bombardieri M, Barone F et al. (2012). Inducible tertiary lymphoid structures formation in a novel model of sialoadenitis in wild-type mice is preceded by ectopic expression of lymphoid chemokines. IMMUNOLOGY Vol.137, () 0019-2805 189-189.
Murray-Brown W, Croia C, Sutcliffe N et al. (2012). Lesional IL-21 expression correlates with functional germinal center formation and T follicular helper cell infiltration in the salivary glands of Sjogren's syndrome. IMMUNOLOGY Vol.137, () 0019-2805 491-491.
Nayar S, Chung MM, Rankin P et al. (2012). Lymphotoxin beta regulates lymphatic vessel expansion in mucosal ectopic lymphoneogenesis. IMMUNOLOGY Vol.137, () 0019-2805 430-430.
Kam NW, Filer A, Buckley C et al. (2012). Membrane-bound and soluble BAFF expression by human rheumatoid fibroblast-like synoviocytes in response to TLR stimulation. IMMUNOLOGY Vol.137, () 0019-2805 583-584.
Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.93, (4) 0959-9673 A6-A7.
Bombardieri M, Pitzalis C (2012). Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis.. Curr Pharm Biotechnol Vol.13, (10) 1989-1996.
Macor P, Durigutto P, De Maso L et al. (2012). Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. ARTHRITIS AND RHEUMATISM Vol.64, (8) 0004-3591 2559-2567.
10.1002/art.34430
Nalesso G, Sherwood J, Bertrand J et al. (2012). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.93, (4) 0959-9673 A8-A8.
Corsiero E, Bombardieri M, Manzo A et al. (2012). Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases.. Immunol Lett Vol.145, (1-2) 62-67.
10.1016/j.imlet.2012.04.013
Pitzalis C (2012). "HUMAN SCID CHIMERAS: MODELS TO DISSECT AUTOIMMUNITY AND INFLAMMATION". ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 40-40.
Sherwood J, Nalesso G, Bertrand J et al. (2012). A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 161-161.
Ng W-F, Lendrem D, Mitchell S et al. (2012). EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 466-466.
Ng W-F, Mitchell S, Lendrem D et al. (2012). HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX (ESSDAI), AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX (ESSPRI) IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME?. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 553-554.
El Shikh ME, Biggioggero M, El Sayed R et al. (2012). REGULATION OF AUTO-ANTIBODY PRODUCTION BY AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 129-129.
Tarn J, Mitchell S, Bowman S et al. (2012). SERUM CYTOKINE AND CHEMOKINE PROFILING IN PRIMARY SJOGREN'S SYNDROME. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 527-528.
Pitzalis C (2012). ADVANCES IN PATHOGENESIS: THE RHEUMATOLOGY VIEW: WHAT BIOLOGICAL PROCESSES DRIVE DIFFERENT DISEASE EXPRESSIONS IN PSA?. RHEUMATOLOGY Vol.51, () 1462-0324 15-15.
Croia C, Bombardieri M, Francesca A et al. (2012). ANTI-VCA AND EBNA1 ANTIBODIES ARE PRODUCED IN THE RHEUMATOID SYNOVIUM IN THE PRESENCE OF ECTOPIC LYMPHOID STRUCTURES AND CORRELATE WITH ACPA PRODUCTION. RHEUMATOLOGY Vol.51, () 1462-0324 43-43.
Ferrari M, Kamalati T, Pitzalis C (2012). DEVELOPMENT OF A NOVEL RECOMBINANT BIOTHERAPEUTIC WITH APPLICATIONS IN TARGETED THERAPY OF HUMAN ARTHRITIS. RHEUMATOLOGY Vol.51, () 1462-0324 123-123.
Nayar S, Cloake T, Bombardieri M et al. (2012). ECTOPIC LYMPHONEOGENESIS IN A NOVEL MURINE MODEL OF SALIVARY GLANDS SIALOADENITIS IS CHARACTERIZED BY ASYNCHRONY IN THE LYMPHANGIOGENETIC AND ANGIOGENETIC PROGRAM. RHEUMATOLOGY Vol.51, () 1462-0324 143-144.
Lendrem D, Mitchell S, Bowman S et al. (2012). EVALUATING HEALTH STATUS OF 620 PATIENTS WITH PRIMARY SJOGREN'S SYNDROME USING EQ-5D. RHEUMATOLOGY Vol.51, () 1462-0324 171-171.
Lendrem D, Mitchell S, Bowman S et al. (2012). HOW GOOD ARE THE EULAR SJOGREN'S SYNDROME DISEASE ACTIVITY INDEX, AND EULAR SJOGREN'S SYNDROME PATIENTS REPORTED INDEX IN PREDICTING HEALTH STATUS IN PRIMARY SJOGREN'S SYNDROME?. RHEUMATOLOGY Vol.51, () 1462-0324 176-176.
Whitehead MA, Bombardieri M, Pitzalis C et al. (2012). Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.. Biochem J Vol.443, (3) 857-867.
10.1042/BJ20112214
Vila J, Mitchell S, Bowman S et al. (2012). THE CLINICAL RELEVANCE OF ANTI-RO52 AND ANTI-RO60 IN PATIENTS IN THE UNITED KINGDOM PRIMARY SJOGREN'S SYNDROME REGISTRY (UKPSSR). RHEUMATOLOGY Vol.51, () 1462-0324 35-35.
DiCicco M, Humby F, Kelly S et al. (2012). THE PATHOBIOLOGY OF EARLY ARTHRITIS COHORT: A PRELIMINARY ANALYSIS CORRELATING HISTOMORPHOLOGY AND DISEASE ACTIVITY. RHEUMATOLOGY Vol.51, () 1462-0324 149-149.
Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC CHEMOKINE SIGNALLING IN CARTILAGE HOMEOSTASIS. OSTEOARTHRITIS AND CARTILAGE Vol.20, () 1063-4584 S116-S116.
Sherwood J, Nalesso G, Bertrand J et al. (2012). ELR plus CXC CHEMOKINE SIGNALLING IN ARTICULAR CHONDROCYTE PHENOTYPIC STABILITY. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 A63-U350.
10.1136/annrheumdis-2011-201237.7
El Shikh MEM, Biggioggero M, El Sayed RM et al. (2012). REGULATION OF AUTO-ANTIBODY PRODUCTION BY PERSISTING AUTO-IMMUNE COMPLEXES ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES Vol.71, () 0003-4967 A38-A38.
10.1136/annrheumdis-2011-201234.15
Pitzalis C, Veale D, Dayer JM (2012). Introduction to "Synovitis--an inflammation of joints destroying the bone".. Swiss Med Wkly Vol.142, () w13712-.
10.4414/smw.2012.13712
Seymour MW, Kelly S, Beals CR et al. (2012). Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study. ARTHRITIS RESEARCH & THERAPY Vol.14, (5) 1478-6354 -.
10.1186/ar4034
Kam NW, Bombardieri M, Filer A et al. (2011). Aberrant basal and TLR-stimulated expression of TSLP in rheumatoid synovial fibroblasts. IMMUNOLOGY Vol.135, () 0019-2805 125-125.
Corsiero E, Sutcliffe N, Wardemann H et al. (2011). Analysis of recombinant monoclonal antibodies from single B cells reveals early defects of B cell tolerance checkpoints in patients with Sjogren's syndrome. IMMUNOLOGY Vol.135, () 0019-2805 72-72.
Kamperidis P, Kamalati T, Ferrari M et al. (2011). Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis.. Arthritis Rheum Vol.63, (12) 3758-3767.
10.1002/art.30650
Nayar S, Barone F, Choy P et al. (2011). Ectopic lymphoneogenesis in a novel murine model of salivary glands sialoadenitis is characterized by asynchrony in the lymphangiogenetic and angiogenetic program. IMMUNOLOGY Vol.135, () 0019-2805 49-49.
Bombardieri M, Lucchesi D, Barone F et al. (2011). Inducible functional tertiary lymphoid structures, autoimmunity and exocrine dysfunction in wild-type mouse salivary glands via local adenoviral delivery. IMMUNOLOGY Vol.135, () 0019-2805 167-167.
Bombardieri M, Kam NW, Brentano F et al. (2011). A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells.. Ann Rheum Dis Vol.70, (10) 1857-1865.
10.1136/ard.2011.150219
Bombardieri M, Kam YNW, Filer A et al. (2011). Aberrant Basal and TLR-Stimulated Expression of TSLP in Rheumatoid Synovial Fibroblasts. ARTHRITIS AND RHEUMATISM Vol.63, (10) 0004-3591 S140-S140.
Miossec P, Verweij CL, Klareskog L et al. (2011). Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies. ANN RHEUM DIS Vol.70, (10) 0003-4967 1713-1718.
10.1136/ard.2011.154252
Kamperidis P, Kamalati T, Ferrari M et al. (2011). Development of a Novel Recombinant Biotherapeutic with Applications in Targeted Therapy of Human Arthritis.. ARTHRITIS AND RHEUMATISM Vol.63, (10) 0004-3591 S499-S499.
Croia C, Bombardieri M, Serafini B et al. (2011). EBV Infection In the Rheumatoid Synovium: Relationship with Ectopic Lymphoid Structures, In Situ Autoantobody Production and CD8 T Cell Activation. ARTHRITIS AND RHEUMATISM Vol.63, (10) 0004-3591 S140-S140.
Bugatti S, Manzo A, Bombardieri M et al. (2011). Synovial Tissue Heterogeneity and Peripheral Blood Biomarkers. CURRENT RHEUMATOLOGY REPORTS Vol.13, (5) 1523-3774 440-448.
10.1007/s11926-011-0201-y
de Hair MJH, Harty LC, Gerlag DM et al. (2011). Synovial Tissue Analysis for the Discovery of Diagnostic and Prognostic Biomarkers in Patients with Early Arthritis. J RHEUMATOL Vol.38, (9) 0315-162X 2068-2072.
10.3899/jrheum.110426
Macor P, Durigutto P, De Maso L et al. (2011). Treatment of antigen-induced and collagen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. MOLECULAR IMMUNOLOGY Vol.48, (14) 0161-5890 1676-1676.
10.1016/j.molimm.2011.06.252
Nalesso G, Sherwood J, Bertrand J et al. (2011). WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways.. J Cell Biol Vol.193, (3) 551-564.
10.1083/jcb.201011051
El Shikh ME, El Sayed R, Kmieciak M et al. (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. RHEUMATOLOGY Vol.50, () 1462-0324 51-51.
Pitzalis C (2011). CAN PATHOBIOLOGY INFORM DISEASE OUTCOME AND RESPONSE TO THERAPY?. RHEUMATOLOGY Vol.50, () 1462-0324 22-22.
Marrelli A, Bombardieri M, Kelly S et al. (2011). DIGITAL IMAGE ANALYSIS FOR THE EVALUATION OF BLOOD VESSEL DENSITY IN RHEUMATOID SYNOVIUM: CORRELATION WITH QUANTITATIVE REAL-TIME PCR EXPRESSION OF ENDOTHELIAL ANTIGEN AND ANGIOGENIC GROWTH FACTORS. RHEUMATOLOGY Vol.50, () 1462-0324 75-75.
Croia C, Serafini B, Bombardieri M et al. (2011). EBV INFECTION IN THE RHEUMATOID ARTHRITIS SYNOVIUM: RELATIONSHIP TO ECTOPIC LYMPHOID STRUCTURES AND CD8 T CELL ACTIVATION. RHEUMATOLOGY Vol.50, () 1462-0324 75-75.
Astorri E, Bombardi M, Peakman M et al. (2011). EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODY PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERIZATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS. RHEUMATOLOGY Vol.50, () 1462-0324 52-53.
Priori R, Barone F, Alessandri C et al. (2011). Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis.. Rheumatology (Oxford) Vol.50, (4) 776-780.
10.1093/rheumatology/keq397
Mahoney DJ, Swales C, Athanasou NA et al. (2011). TSG-6 Inhibits Osteoclast Activity via an Autocrine Mechanism and Is Functionally Synergistic With Osteoprotegerin. ARTHRITIS RHEUM-US Vol.63, (4) 0004-3591 1034-1043.
10.1002/art.30201
Bugatti S, Manzo A, Vitolo B et al. (2011). B CELL DISTRIBUTION AND ACTIVATION-INDUCED CYTIDINE DEAMINASE EXPRESSION IN RHEUMATOID SYNOVITIS: CLINICAL AND BIO-MOLECULAR CORRELATES. ANNALS OF THE RHEUMATIC DISEASES Vol.70, () 0003-4967 A55-A55.
10.1136/ard.2010.148999.4
El Shikh ME, El Sayed RM, Kmieciak M et al. (2011). BREAKAGE OF B CELL TOLERANCE BY ANTIGENS ON FOLLICULAR DENDRITIC CELLS. ANNALS OF THE RHEUMATIC DISEASES Vol.70, () 0003-4967 -.
10.1136/ard.2010.148999.9
Astorri E, Bombardieri M, Gabba S et al. (2011). EVOLUTION OF ECTOPIC LYMPHOID NEOGENESIS AND IN SITU AUTOANTIBODIES PRODUCTION IN AUTOIMMUNE DIABETIC NOD MICE: CELLULAR AND MOLECULAR CHARACTERISATION OF TERTIARY LYMPHOID STRUCTURES IN PANCREATIC ISLETS. ANNALS OF THE RHEUMATIC DISEASES Vol.70, () 0003-4967 -.
10.1136/ard.2010.148999.2
de Sande MGHV, Gerlag DM, Lodde BM et al. (2011). Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. ANN RHEUM DIS Vol.70, (3) 0003-4967 423-427.
10.1136/ard.2010.139550
Astorri E (2011). Interplay between inflammation, autoimmunity and regeneration in the NOD mouse model of type 1 diabetes and Sjogren’s syndrome.. Vol., () -.
Humby F (2011). The clinical and immunological significance of ectopic lymphoneogenesis within the rheumatoid synovial membrane. Vol., () -.
Pitzalis C (2011). THE ROLE OF SYNOVIAL BIOPSY IN THE DIAGNOSIS OF INFLAMMATORY ARTHRITIS. CLIN EXP RHEUMATOL Vol.29, (1) 0392-856X 154-154.
Patel HB, Bombardieri M, Sampaio AL et al. (2010). Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis.. FASEB J Vol.24, (12) 4835-4843.
10.1096/fj.10-167759
Corsiero E, Bombardieri M, Humby F et al. (2010). Characterization of inter follicular large B cells, a new subpopulation of B lymphocytes, in tertiary lymphoid organs in rheumatic autoimmune diseases. IMMUNOLOGY Vol.131, () 0019-2805 33-33.
Astorri E, Guglielmi C, Bombardieri M et al. (2010). Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes.. Horm Metab Res Vol.42, (13) 955-960.
10.1055/s-0030-1267206
Croia C, Serafini B, Bombardieri M et al. (2010). EBV infection in the rheumatoid arthritis synovium: relationship to tertiary lymphoid structures and CD8 T cell activation. IMMUNOLOGY Vol.131, () 0019-2805 124-124.
Astorri E, Bombardieri M, Gabba S et al. (2010). Evolution of ectopic lymphoid neogenesis and in-situ autoantibodies production in autoimmune diabetic NOD mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islet. IMMUNOLOGY Vol.131, () 0019-2805 63-63.
Lucchesi D, Astorri E, Bombardieri M et al. (2010). Molecular and cellular evolution of functional tertiary lymphoid structures in salivary glands of NOD mice. IMMUNOLOGY Vol.131, () 0019-2805 59-59.
Kam NW, Bombardieri M, Brentano F et al. (2010). Rheumatoid synovial fibroblasts support AID expression and Ig class-switching in B cells via a Baff-dependent TLR3-stimulated pathway. IMMUNOLOGY Vol.131, () 0019-2805 71-71.
Ciccia F, Bombardieri M, Rizzo A et al. (2010). Over-expression of paneth cell-derived anti-microbial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation.. Rheumatology (Oxford) Vol.49, (11) 2076-2083.
10.1093/rheumatology/keq239
Sherwood J, Key S, Achan P et al. (2010). CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. OSTEOARTHRITIS AND CARTILAGE Vol.18, () 1063-4584 S96-S96.
Nalesso G, Achan P, Pitzalis C et al. (2010). WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS. OSTEOARTHRITIS AND CARTILAGE Vol.18, () 1063-4584 S104-S105.
Astorri E, Bombardieri M, Gabba S et al. (2010). Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets.. J Immunol Vol.185, (6) 3359-3368.
10.4049/jimmunol.1001836
Shirlaw P, Hullah E, Barone F et al. (2010). Changes in parameters of Sjogrens syndrome (SS) assessed after 10 years on a combined SS clinic. ORAL DIS Vol.16, (6) 1354-523X 539-539.
Connolly M, Marrelli A, Blades M et al. (2010). Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model. J IMMUNOL Vol.184, (11) 0022-1767 6427-6437.
10.4049/jimmunol.0902941
Sherwood JC, Achan P, Ramachandran M et al. (2010). CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES. RHEUMATOLOGY Vol.49, () 1462-0324 I13-I13.
Sherwood JC, Pitzalis C, Dell'Accio F (2010). CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.91, (2) 0959-9673 A40-A40.
Nalesso G, Eltawil NM, Pitzalis C et al. (2010). Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.91, (2) 0959-9673 A40-A41.
Astorri E, Bombardieri M, Corsiero E et al. (2010). MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE. RHEUMATOLOGY Vol.49, () 1462-0324 I28-I28.
10.1093/rheumatology/keq710
Eltawil N, Pitzalis C, Dell'Accio F (2010). Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.91, (2) 0959-9673 A29-A29.
Bombardieri M, Kam YNW, Brentano F et al. (2010). RHEUMATOID SYNOVIAL FIBROBLASTS SUPPORT AID EXPRESSION AND IG CLASS-SWITCHING IN B CELLS VIA A BAFF-DEPENDENT TLR3-STIMULATED PATHWAY. RHEUMATOLOGY Vol.49, () 1462-0324 I26-I27.
Swales C, Mahoney DJ, Athanasou NA et al. (2010). TSG-6: AN AUTOCRINE REGULATOR OF INFLAMMATORY JOINT DISEASE?. RHEUMATOLOGY Vol.49, () 1462-0324 I27-I27.
Bombardieri M, Astorri E, Corsiero E et al. (2010). MOLECULAR AND CELLULAR EVOLUTION OF FUNCTIONAL TERTIARY LYMPHOID STRUCTURES IN SALIVARY GLANDS OF NOD MICE. ANNALS OF THE RHEUMATIC DISEASES Vol.69, () 0003-4967 -.
10.1136/ard.2010.129585e
Manzo A, Bombardieri M, Humby F et al. (2010). Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. IMMUNOL REV Vol.233, () 0105-2896 267-285.
10.1111/j.0105-2896.2009.00861.x
Duchene J, Cayla C, Vessillier S et al. (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis.. Arterioscler Thromb Vasc Biol Vol.29, (11) 1757-1763.
10.1161/ATVBAHA.109.191775
Scheiermann C, Colom B, Meda P et al. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.. Arterioscler Thromb Vasc Biol Vol.29, (10) 1509-1515.
10.1161/ATVBAHA.109.187559
Macor P, Durigutto P, De Maso L et al. (2009). Prevention of antigen-induced arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5. MOLECULAR IMMUNOLOGY Vol.46, (14) 0161-5890 2837-2837.
10.1016/j.molimm.2009.05.239
Garrood T, Blades M, Haskard DO et al. (2009). A novel model for the pre-clinical imaging of inflamed human synovial vasculature.. Rheumatology (Oxford) Vol.48, (8) 926-931.
10.1093/rheumatology/kep117
Robinson H, Kelly S, Pitzalis C (2009). Basic synovial biology and immunopathology in psoriatic arthritis.. J Rheumatol Suppl Vol.83, () 0380-0903 14-16.
10.3899/jrheum.090212
Eltawil NM, De Bari C, Achan P et al. (2009). A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury.. Osteoarthritis Cartilage Vol.17, (6) 695-704.
10.1016/j.joca.2008.11.003
Evans HG, Gullick NJ, Kelly S et al. (2009). In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses.. Proc Natl Acad Sci U S A Vol.106, (15) 6232-6237.
10.1073/pnas.0808144106
Patel HB, Bombardieri M, Pitzalis C et al. (2009). Activation of melanocortin receptor type 3 as a new strategy to control experimental and rheumatoid arthritis. EUR J CLIN INVEST Vol.39, () 0014-2972 29-29.
Colom B, Scheiermann C, Woodfin A et al. (2009). Effect of soluble JAM-C on leukocyte transmigration in models of ischemia/reperfusion injury. FASEB JOURNAL Vol.23, () 0892-6638 -.
Bombardieri M, Ciccia F, Principato A et al. (2009). IL-23 OVEREXPRESSION AS IMMUNOLOGICAL SIGNATURE OF SUBCLINICAL INTESTINAL INFLAMMATION IN ANKYLOSING SPONDYLITIS. RHEUMATOLOGY Vol.48, () 1462-0324 I6-I6.
Ciccia F, Bombardieri M, Principato A et al. (2009). Overexpression of Interleukin-23, but Not Interleukin-17, as an Immunologic Signature of Subdinical Intestinal Inflammation in Ankylosing Spondylitis. ARTHRITIS RHEUM Vol.60, (4) 0004-3591 955-965.
10.1002/art.24389
Garrood T, Lee L, Blades M et al. (2009). TNF-ALPHA MODULATES TISSUE-SPECIFIC VASCULAR DETERMINANTS RECOGNIZED IN VIVO BY A PHAGE CLONE DISPLAYING A SYNOVIAL-HOMING PEPTIDE IN THE HUMAN/SCID MOUSE TRANSPLANTATION MODEL. RHEUMATOLOGY Vol.48, () 1462-0324 I39-I39.
Dell'Accio F, Eltawil NM, De Bari C et al. (2009). WNT16 in joint surface injury and osteoarthritis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol.90, (1) 0959-9673 A84-A84.
Kamperidis P (2009). Identification of Single-Chain Antibody Fragments Specific for Human Synovial Microvasclar Endothelium by In-Vivo Phage Display. Vol., () -.
Humby F, Bombardieri M, Manzo A et al. (2009). Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium.. PLoS Med Vol.6, (1) e1-.
10.1371/journal.pmed.0060001
Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients. IMMUNOLOGY Vol.125, () 0019-2805 59-59.
Manzo A, Vitolo B, Humby F et al. (2008). Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint. ARTHRITIS RHEUM Vol.58, (11) 0004-3591 3377-3387.
10.1002/art.23966
El Tawil NM, De Bari C, Pitzalis C et al. (2008). A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome. ARTHRITIS AND RHEUMATISM Vol.58, (9) 0004-3591 S647-S647.
Connolly M, McCormick J, Marelli A et al. (2008). A-SAA induces rho GTPase-dependent cytoskeletal rearrangement and in vivo migration of fluorochrome labelled monocytic (u937) cells in a human RA/SCID mice chimera model. ARTHRITIS AND RHEUMATISM Vol.58, (9) 0004-3591 S627-S627.
Humby F, Bombardieri M, Antonio M et al. (2008). Ectopic lymphoid structures expressing AID drive self sustained in situ prodction of autoantibodies in rheumatoid synovium. ARTHRITIS AND RHEUMATISM Vol.58, (9) 0004-3591 S633-S634.
Bugatti S, Manzo A, Caporali R et al. (2008). Lymphocyte organisation and lymphatic angiogenesis in rheumatoid synovitis: Clinical and radiographic correlates. ARTHRITIS AND RHEUMATISM Vol.58, (9) 0004-3591 S767-S768.
Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of Th17 cells by synovial monocytes from active rheumatoid arthritis patients. ARTHRITIS AND RHEUMATISM Vol.58, (9) 0004-3591 S634-S634.
Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of th17 cells by synovial monocytes from active rheumatoid arthritis patients. ARTHRITIS AND RHEUMATISM Vol.58, (9) 0004-3591 S165-S166.
Humby F, Gullick N, Kelly S et al. (2008). A synovial pathergy reaction leading to a pseudo-septic arthritis and a diagnosis of Behcet's disease. RHEUMATOLOGY Vol.47, (8) 1462-0324 1255-1256.
10.1093/rheumatology/ken194
Kelly S, Taylor P, Pitzalis C (2008). Ultrasound imaging in spondyloathropathies: from imaging to diagnostic intervention.. Curr Opin Rheumatol Vol.20, (4) 408-415.
10.1097/BOR.0b013e328303e1ad
Dell'accio F, De Bari C, Eltawil NM et al. (2008). Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis.. Arthritis Rheum Vol.58, (5) 0004-3591 1410-1421.
10.1002/art.23444
Bombardieri M, Barone F, Humby F et al. (2008). Activation-induced cytidine deaminase expression supports functionality of ectopic lymphoid neogenesis in patients with and animal models of Sjogren's syndrome. RHEUMATOLOGY Vol.47, () 1462-0324 II85-II85.
Humby F, Bombardieri M, Manzo A et al. (2008). Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium. RHEUMATOLOGY Vol.47, () 1462-0324 II59-II59.
Barone F, Bombardieri M, Rosado MM et al. (2008). CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: Association with reactive and malignant areas of lymphoid organization. J IMMUNOL Vol.180, (7) 0022-1767 5130-5140.
Garrood T, Blades M, Mather S et al. (2008). Imaging E-selectin expression in human synovium in a scid mouse transplantation model. RHEUMATOLOGY Vol.47, () 1462-0324 II55-II55.
Evans HG, Gullick NJ, Kelly S et al. (2008). Potent induction of interleukin-17 producing CD4+ T cells (TH17 cells) by synovial monocytes from active RA patients. RHEUMATOLOGY Vol.47, () 1462-0324 II59-II59.
Dell'Accio F, Eltawil NM, De Bari C et al. (2008). Wnt16 in joint surface injury and osteoarthritis. RHEUMATOLOGY Vol.47, () 1462-0324 II177-II178.
Bombardieri M, Barone F, Pitzalis C (2008). Response to comment on "Activation-Induced Cyridine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis aud MALT Lymphoma in Sjogren's Syndrome". J IMMUNOL Vol.180, (4) 0022-1767 2008-2009.
De Bari C, Dell'Accio F, Karystinou A et al. (2008). A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells.. Arthritis Rheum Vol.58, (1) 0004-3591 240-250.
10.1002/art.23143
Evans H, Gullick N, Kelly S et al. (2008). Potent induction of interleukin-17 producing CD4+T cells (Th17 cells) by synovial monocytes from active RA patients. CLINICAL IMMUNOLOGY Vol.127, () 1521-6616 S20-S20.
10.1016/j.clim.2008.03.497
Manzo A (2008). Re-programming of the CXCL13-CCL21 Lymphoid Chemokine System in Ectopic Lymphoid Neogenesis during Chronic Arthritis.. Vol., () -.
Manzo A, Bugatti S, Caporali R et al. (2007). CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. AM J PATHOL Vol.171, (5) 0002-9440 1549-1562.
10.2353/ajpath.2007.061275
Manzo A, Pitzalis C (2007). Lymphoid tissue reactions in rheumatoid arthritis.. Autoimmun Rev Vol.7, (1) 1568-9972 30-34.
10.1016/j.autrev.2007.03.006
Bombardieri M, Barone F, Humby F et al. (2007). Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome.. J Immunol Vol.179, (7) 0022-1767 4929-4938.
Brunton F, Lee L, Nissim A et al. (2007). Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin. JOURNAL OF BONE AND MINERAL RESEARCH Vol.22, (7) 0884-0431 1113-1113.
Humby F, Manzo A, Kirkham B et al. (2007). The synovial membrane as a prognostic tool in rheumatoid arthritis.. Autoimmun Rev Vol.6, (4) 1568-9972 248-252.
10.1016/j.autrev.2006.08.013
Scire CA, Epis O, Codullo V et al. (2007). Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. ARTHRITIS RES THER Vol.9, (5) 1478-6354 -.
10.1186/ar2302
Lee L, Garrood T, Pitzalis C (2007). In vivo phage display selection in the human/SCID mouse chimera model for defining synovial specific determinants.. Methods Mol Med Vol.136, () 1543-1894 369-394.
Bombardieri M, McInnes IB, Pitzalis C (2007). Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions.. Expert Opin Biol Ther Vol.7, (1) 31-40.
10.1517/14712598.7.1.31
DELL'ACCIO F, Pitzalis C, Barone F et al. (2006). Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Research & Therapy Vol.8, (5) 1478-6354 R139-R139.
10.1186/ar2029
PITZALIS C, Barone F, Peakman M et al. (2006). Atorvastatin fails to prevent the development of autoimmune diabetes despite inhibition of pathogenic beta-cell-specific CD8 T-cells. Diabetes Vol.55, (4) 1004-1010.
PITZALIS C, Manzo A, Bombardieri M et al. (2005). Association of CXCL13 and CCL21 Expression With the Progressive Organization of Lymphoid-like Structures in Sjogren’s Syndrome. Arthritis & Rheumatism Vol.52, (6) 0004-3591 1773-1784.
10.1002/art.21062
PITZALIS C, Manzo A, Uguccioni M et al. (2005). Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol Vol.35, () 1347-1359.
Perretti M, Ingegnoli F, Wheller SK et al. (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model.. J Immunol Vol.169, (4) 0022-1767 2085-2092.
PITZALIS C, Lee L, Panayi G et al. (2002). Identification of Synovium-Specific Homing Peptides by In Vivo Phage Display Selection. Arthritis & Rheumatism Vol.46, (8) 0004-3591 2109-2120.
10.1002/art.10464
Blades MC, Manzo A, Ingegnoli F et al. (2002). Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J IMMUNOL Vol.168, (9) 0022-1767 4308-4317.
Perretti M, Blades MC, Wheller SK et al. (2002). Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo. FASEB J Vol.16, (4) 0892-6638 A598-A598.
Blades MC, Ingegnoli F, Wheller SK et al. (2002). Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID mice. ARTHRITIS RHEUM Vol.46, (3) 0004-3591 824-836.
10.1002/art.10102
Pitzalis C, Pipitone N, Perretti M (2002). Regulation of leukocyte-endothelial interactions by glucocorticoids. NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES II, PROCEEDINGS Vol.966, () 0077-8923 108-118.
Pipitone N, Sinha M, Theodoridis E et al. (2001). The glucocorticoid inhibition of LFA-1 and CD2 expression by human mononuclear cells is reversed by IL-2, IL-7 and IL-15. EUR J IMMUNOL Vol.31, (7) 0014-2980 2135-2142.
10.1002/1521-4141(200107)31:7<2135::AID-IMMU2135>3.0.CO;2-S

Sponsors

Arthritis Research UK

Barts and The London Charity

Medical Research Council

Nuffield Foundation

National Institute for Health Research

Wellcome Trust

Collaborators

Internal: Professor Francesco Dell'Accio; Dr Michele Bombardieri; Dr Mohey El Shikh; Dr Frances Humby; Dr Stephen Kelly;
External: Doug Veale; Chris Buckley; Iain McInnes; Peter Taylor

Contact

Costantino Pitzalis, MD, PhD, FRCP
Professor of Experimental Medicine & Rheumatology Centre for Experimental Medicine & Rheumatology
William Harvey Research Institute
Barts and The London, Queen Mary's School of Medicine and Dentistry
2nd Floor John Vane Science Building
Charterhouse Square
London, EC1M 6BQ
T: +44 (0) 20 7882 8191
E: This email address is being protected from spambots. You need JavaScript enabled to view it.

^ Back to Top