Roderick Flower, FRS

Rod Flower

Professor of Biochemical Pharmacology

I read physiology at the University of Sheffield and graduated with a first class honours degree in 1971.  I went to the Royal College of Surgeons for my postgraduate training with John Vane (later Sir John, Nobel Laureate) and was awarded a PhD by the University of London in 1974.  I worked with John Vane and other colleagues for 11 years at the Wellcome Foundation in Kent (then a major pharmaceutical company) before moving to the University of Bath to take up the Chair of Pharmacology in the School of Pharmacy and Pharmacology in 1985. 
In 1990, I returned to London to (what was then) St. Bart’s Hospital Medical School and together with John Vane and other colleagues, co-founded the William Harvey Research Institute, serving as Institute Director from 2000-2004. My scientific output during my time here has been funded chiefly by a succession of programme grants from the Wellcome Trust.
I also have an interest in biosecurity matters. I chaired the Royal Society’s Scientific Aspects of International Security committee from 2006-2010 and have collaborated with the American Academy of Sciences and other organisations to review issues surrounding the misuse of science. I recently chaired the Royal Society’s Brain Waves project dealing with Neuroscience, conflict and security.
I was a Principal Fellow of the Wellcome Trust from 1994-2007 and was elected to fellowship of the Academy of Medical Sciences (1999) and the Royal Society (2003).  I was president of the British Pharmacological Society (2000-2003). I have published over 350 papers and books including co-authoring a best-selling pharmacology textbook. I have been awarded several national and international awards including the Life Time Achievement Award of the International Association of Inflammation Societies (2005).

Summary of Research

Inflammation and anti-inflammatory drug action.

I have spent the majority of my career working in on inflammation and anti-inflammatory drug mechanisms.  I was one of the original team that discovered how aspirin and aspirin-like drugs worked (1971) and I have retained an interest in ‘Cox’ pharmacology to this day. During my early career, I also researched platelet pharmacology. Together with a colleague, I invented a novel type of ‘platelet aggregometer’, which functions in whole blood: this is still in current use in hospitals and laboratories around the world. My main interest however concerns the mechanism of action of the anti-inflammatory glucocorticoids. Our lab discovered that glucocorticoids can release a protein (called Annexin A1) from some cell types and that this mediates many of the acute effects of these hormone-drugs including their anti-inflammatory actions.  Over the years we have studied this protein in great detail developing transgenic mice lacking the Annexin A1 gene to aid us with our studies. We also discovered recently that the cromone anti-allergic drugs work in a broadly similar fashion although utilising a different biochemical pathway. My current interest focuses on the biology of the Annexin A1 G-protein coupled receptor, ALX/FPR2 and its possible use as a novel therapeutic target.

Key Publications

Publications. (10 selected from last 5 years) Yedgar S, Krimsky M, Cohen Y, Flower RJ (2007). Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword? Trends Pharmacol Sci 28(9): 459-464.

D'Acquisto F, Perretti M, Flower RJ (2008). Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. Br J Pharmacol 155(2): 152-169.

Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, et al. (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461(7268): 1287-1291.

Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R (2009). Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochem Pharmacol 77(12): 1814-1826.

Dufton N, Hannon R, Brancaleone V, Dalli J, Patel HB, Gray M, et al. (2010). Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J Immunol 184(5): 2611-2619.

Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M, et al. (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol 30(9): 1718-1724.

Brancaleone V, Dalli J, Bena S, Flower RJ, Cirino G, Perretti M (2011). Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature. J Immunol 186(8): 4905-4914.

Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN (2011). Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol 186(10): 5543-5547.

Bena S, Brancaleone V, Wang JM, Perretti M, Flower RJ (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling. J Biol Chem 287(29): 24690-24697.

Flower R (2012). The Osler Lecture 2012: 'pharmacology 2.0, medicines, drugs and human enhancement'. QJM : monthly journal of the Association of Physicians 105(9): 823-830.

PubLists Publications

Flower RJ (2013). Pharmacology 2.0.. Br J Clin Pharmacol Vol.76, (5) 625-629.
10.1111/bcp.12088
Yazid S, Sinniah A, Solito E et al. (2013). Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1.. PLoS One Vol.8, (3) e58963-.
10.1371/journal.pone.0058963
Kosicka A, Cunliffe AD, Mackenzie R et al. (2013). Attenuation of plasma annexin A1 in human obesity. FASEB JOURNAL Vol.27, (1) 0892-6638 368-378.
10.1096/fj.12-213728
Yazid S, Norling LV, Flower RJ (2012). Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system.. Prostaglandins Other Lipid Mediat Vol.98, (3-4) 1098-8823 94-100.
10.1016/j.prostaglandins.2011.11.005
Norling LV, Dalli J, Flower RJ et al. (2012). Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.. Arterioscler Thromb Vasc Biol Vol.32, (8) 1970-1978.
10.1161/ATVBAHA.112.249508
Bena S, Brancaleone V, Wang JM et al. (2012). Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.. J Biol Chem Vol.287, (29) 24690-24697.
10.1074/jbc.M112.377101
Norling LV, Dalli J, Flower RJ et al. (2012). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. FASEB JOURNAL Vol.26, () 0892-6638 -.
Ayoub SS, Pryce G, Seed MP et al. (2011). Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.. Drug Metab Dispos Vol.39, (9) 1689-1695.
10.1124/dmd.111.038638
Brancaleone V, Sampaio AL, Cirino G et al. (2011). A NOVEL CROSS-TALK IN RESOLUTION: H2S ACTIVATES THE ANNEXIN A1 PATHWAY. INFLAMMATION RESEARCH Vol.60, () 1023-3830 49-49.
Norling LV, Spite M, Yang R et al. (2011). Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. J IMMUNOL Vol.186, (10) 0022-1767 5543-5547.
10.4049/jimmunol.1003865
Brancaleone V, Dalli J, Bena S et al. (2011). Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.. J Immunol Vol.186, (8) 4905-4914.
10.4049/jimmunol.1003145
Seidel S, Paliege A, Bachmann S et al. (2011). Localization and signaling of FPR2 in the kidney. FASEB JOURNAL Vol.25, () 0892-6638 -.
Holloway PM, Smith HK, Renshaw D et al. (2011). Targeting the melanocortin receptor system for anti-stroke therapy. TRENDS PHARMACOL SCI Vol.32, (2) 0165-6147 90-98.
10.1016/j.tips.2010.11.010
Damazo AS, Sampaio AL, Nakata CM et al. (2011). Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis.. BMC Immunol Vol.12, () 59-.
10.1186/1471-2172-12-59
Yazid S, Leoni G, Getting SJ et al. (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.. Arterioscler Thromb Vasc Biol Vol.30, (9) 1718-1724.
10.1161/ATVBAHA.110.209536
Yazid S, Ayoub SS, Solito E et al. (2010). Anti-allergic drugs and the Annexin-A1 system.. Pharmacol Rep Vol.62, (3) 1734-1140 511-517.
Norling LV, Dalli J, Flower RJ et al. (2010). Resolvin D1 limits PMN recruitment to inflammatory loci: receptor dependent bioactions. FASEB JOURNAL Vol.24, () 0892-6638 -.
Dalli J, Cavalcanti DM, Farksy SH et al. (2010). Abnormalities in annexin a1 null bone marrow cells: evidence for failure of clearance of apoptotic neutrophils. EUR J CLIN INVEST Vol.40, () 0014-2972 49-49.
Dufton N, Hannon R, Brancaleone V et al. (2010). Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.. J Immunol Vol.184, (5) 2611-2619.
10.4049/jimmunol.0903526
Perretti M, Dufton N, Dalli J et al. (2010). Fpr2 down-regulates leukocyte trafficking in vascular inflammation. EUR J CLIN INVEST Vol.40, () 0014-2972 24-24.
Paschalidis N, Huggins A, Rowbotham NJ et al. (2010). Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. CELL CYCLE Vol.9, (4) 1538-4101 785-794.
10.4161/cc.9.4.10673
Paschalidis N, Huggins A, Rowbotham NJ et al. (2010). Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.. Cell Cycle Vol.9, (4) 784-793.
Flower RJ (2010). In vitro cyclo-oxygenase expression and activity protocols: Introduction to Part I.. Methods Mol Biol Vol.644, () 3-10.
10.1007/978-1-59745-364-6_1
Spite M, Norling LV, Summers L et al. (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. NATURE Vol.461, (7268) 0028-0836 1287-U125.
10.1038/nature08541
Bolton C, Wood EG, Scott GS et al. (2009). A comparative evaluation of the response to peroxynitrite by a brain endothelial cell line and control of the effects by drug targeting.. Cell Mol Neurobiol Vol.29, (5) 707-717.
10.1007/s10571-009-9391-5
Huggins A, Paschalidis N, Flower RJ et al. (2009). Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.. FASEB J Vol.23, (4) 985-996.
10.1096/fj.08-119040
Perretti M, Dufton N, Patel HB et al. (2009). The role of ALX/FPRL-1 in inflammation and its impact on Annexin A1 biology. EUR J CLIN INVEST Vol.39, () 0014-2972 24-24.
Gastardelo TS, Damazo AS, Dalli J et al. (2009). Functional and Ultrastructural Analysis of Annexin A1 and Its Receptor in Extravasating Neutrophils during Acute Inflammation. AM J PATHOL Vol.174, (1) 0002-9440 177-183.
10.2353/ajpath.2009.080342
Paschalidis N, Iqbal AJ, Maione F et al. (2009). Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1.. J Neuroinflammation Vol.6, () 33-.
10.1186/1742-2094-6-33
Bolton C, Scott GS, Smith T et al. (2008). The acute and chronic phases of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE) are ameliorated by the peroxynitrite decomposition catalyst, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinatoiron (III) chloride, (FeTPPS).. Eur J Pharmacol Vol.601, (1-3) 88-93.
10.1016/j.ejphar.2008.10.029
Babbin BA, Laukoetter MG, Nava P et al. (2008). Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J IMMUNOL Vol.181, (7) 0022-1767 5035-5044.
D'Acquisto F, Perretti M, Flower RJ (2008). Annexin-A1: a pivotal regulator of the innate and adaptive immune systems. BRIT J PHARMACOL Vol.155, (2) 0007-1188 152-169.
10.1038/bjp.2008.252
Ayoub SS, Yazid S, Flower RJ (2008). Increased susceptibility of annexin-A1 null mice to nociceptive pain is indicative of a spinal antinociceptive action of annexin-A1. BRIT J PHARMACOL Vol.154, (5) 0007-1188 1135-1142.
10.1038/bjp.2008.166
D'Acquisto F, Paschalidis N, Raza K et al. (2008). Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4(+) T cells. RHEUMATOLOGY Vol.47, (5) 1462-0324 636-639.
10.1093/rheumatology/ken062
Martin GR, Perretti M, Flower RJ et al. (2008). Annexin-1 modulates repair of gastric mucosal injury. AM J PHYSIOL-GASTR L Vol.294, (3) 0193-1857 G764-G769.
10.1152/ajpgi.00531.2007
Damazo AS, Flower RJ, Solito E et al. (2008). Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia. INFLAMM RES Vol.57, (3) 1023-3830 97-103.
10.1007/s00011-007-7114-2
D'Acquisto F, Paschalidis N, Sampaio ALF et al. (2007). Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. EUR J IMMUNOL Vol.37, (11) 0014-2980 3131-3142.
10.1002/eji.200636792
Vong L, D'Acquisto F, Pederzoli-Ribeil M et al. (2007). Annexin 1 cleavage in activated neutrophils - A pivotal role for proteinase 3. J BIOL CHEM Vol.282, (41) 0021-9258 29998-30004.
10.1074/jbc.M702876200
Yedgar S, Krimsky M, Cohen Y et al. (2007). Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword?. TRENDS PHARMACOL SCI Vol.28, (9) 0165-6147 459-464.
10.1016/j.tips.2007.07.005
Damazo AS, Moradi-Bidhendi N, Oliani SM et al. (2007). Role of annexin 1 gene expression in mouse craniofacial bone development. BIRTH DEFECTS RES A Vol.79, (7) 1542-0752 524-532.
10.1002/bdra.20368
Flower RJ, PERRETTI M, Gavins FN et al. (2007). Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. The FASEB Journal Vol.21, (8) 0892-6638 1751-1758.
10.1096/fj.06-7842com
John CD, Sahni V, Mehet D et al. (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. FASEB J Vol.21, (4) 0892-6638 1037-1046.
10.1096/fj.06-7299com
D'Acquisto F, Merghani A, Lecona E et al. (2007). Annexin-1 modulates T-cell activation and differentiation. BLOOD Vol.109, (3) 0006-4971 1095-1102.
10.1182/blood-2006-05-022798
Scott GS, Bowman SR, Smith T et al. (2007). Glutamate-stimulated peroxynitrite production in a brain-derived endothelial cell line is dependent on N-methyl-D-aspartate (NMDA) receptor activation.. Biochem Pharmacol Vol.73, (2) 0006-2952 228-236.
10.1016/j.bcp.2006.09.021
Warne JP, John CD, Christian HC et al. (2006). Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. AM J PHYSIOL-ENDOC M Vol.291, (6) 0193-1849 E1264-E1273.
10.1152/ajpendo.00655.2005
Flower RJ, Ayoub S, Perretti M (2006). Anti-inflammatory and analgesic aspects of the annexin A1 system. ACTA PHARMACOL SIN Vol.27, (9) 1671-4083 1272-1272.
Flower RJ, Perretti M, D'Acquisto F et al. (2006). Annexin 1, anti-inflammatory drugs and the neuroendocrine-immune interface.. ACTA PHARMACOL SIN Vol.27, () 1671-4083 6-6.
FLOWER RJ, Perretti M, Gordon S et al. (2006). Impaired phagocytic mechanism in annexin 1 null macrophages. Br J Pharmacol Vol.148, (4) 469-477.
10.1038/sj.bjp.0706730
Damazo AS, Yona S, Flower RJ et al. (2006). Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J IMMUNOL Vol.176, (7) 0022-1767 4410-4418.
D'Acquisto F, Merghani A, Lecona E et al. (2006). Annexin A1: a novel target of the immunosuppressive effects of glucocorticoids in autoimmune diseases. FASEB JOURNAL Vol.20, (5) 0892-6638 A1376-A1376.
Vo PA, Flower RJ, D'Acquisto F (2006). Inflammatory stimuli modulate the Annexin-A1 promoter by in human monocytes. FASEB JOURNAL Vol.20, (5) 0892-6638 A1376-A1376.
Vong L, D'Acquisto F, Flower RJ et al. (2006). Cleavage of Annexin-A1 by proteinase 3: a possible cause of Wegener's vasculitis?. FASEB JOURNAL Vol.20, (4) 0892-6638 A645-A645.
Hayhoe RPG, Kamal AM, Solito E et al. (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. BLOOD Vol.107, (5) 0006-4971 2123-2130.
10.1182/blood-2005-08-3099
Buckingham JC, John CD, Solito E et al. (2006). Annexin 1, glucocorticoids, and the neuroendocrine-immune interface. NEUROENDOCRINE AND IMMUNE CROSSTALK Vol.1088, () 0077-8923 396-409.
10.1196/annals.1366.002
Kamal AM, Hayhoe RP, Paramasivam A et al. (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1.. ScientificWorldJournal Vol.6, () 1375-1384.
10.1100/tsw.2006.247
Flower RJ (2006). Prostaglandins, bioassay and inflammation.. Br J Pharmacol Vol.147 Suppl 1, () 0007-1188 S182-S192.
10.1038/sj.bjp.0706506
Moraes LA, Paul-Clark MJ, Rickman A et al. (2005). Ligand-specific glucocorticoid receptor activation in human platelets. BLOOD Vol.106, (13) 0006-4971 4167-4175.
10.1182/blood-2005-04-1723
Flower RJ, PERRETTI M, Damazo AS et al. (2005). Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation.. Am J Pathol Vol.166, (6) 0002-9440 1607-1617.
10.1016/S0002-9440(10)62471-6
Flower RJ, Perretti M (2005). Controlling inflammation: a fat chance?. J Exp Med Vol.201, (5) 0022-1007 671-674.
10.1084/jem.20050222
Perretti M, Damazo AS, Yona S et al. (2005). Critical protective role for annexin 1 gene expression in mouse endotoxemia. FASEB JOURNAL Vol.19, (5) 0892-6638 A1221-A1222.
Perretti M, Chatterjee BE, Yona S et al. (2005). Higher degree of neutrophil activation in vitro and within the microcirculation in absence of annexin 1 (Anx-A1) gene. FASEB JOURNAL Vol.19, (5) 0892-6638 A1262-A1262.
Kamal AM, Flower RJ, Perretti M (2005). An overview of the effects of annexin 1 on cells involved in the inflammatory process. MEMORIAS DO INSTITUTO OSWALDO CRUZ Vol.100, () 0074-0276 39-47.
10.1590/S0074-02762005000900008
Yona S, Ward B, Buckingham JC et al. (2005). Macrophage biology in the Anx-A1(-/-) mouse. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS Vol.72, (2) 0952-3278 95-103.
10.1016/j.plefa.2004.10.008
Flower RJ, PERRETTI M, Diaz BL et al. (2005). A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat.. J Pharmacol Exp Ther Vol.313, (3) 1416-1422.
10.1124/jpet.104.080473
Flower RJ, PERRETTI M, Nourshargh S et al. (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol Vol.78, (3) 639-646.
10.1189/jlb.0405206
Monteith DT, HILDREW AG, Flower RJ et al. (2005). Biological responses to the chemical recovery of acidified fresh waters in the UK.. Environmental Pollution Vol.137, (1) 83-101.
10.1016/j.envpol.2004.12.026
Scott GS, Flower RJ, Bolton C (2004). Therapeutic effects of peroxynitrite decomposition catalysts in experimental allergic encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY Vol.154, (1-2) 0165-5728 84-84.
Bandeira-Melo C, Silva PMR, Carvalho VF et al. (2004). A novel effect for annexin 1-derived peptide Ac2-26: reduction of allergic inflammation in rats. FUNDAMENTAL & CLINICAL PHARMACOLOGY Vol.18, () 0767-3981 93-93.
Perretti M, Flower RJ (2004). Annexin 1 and the biology of the neutrophil.. J Leukoc Biol Vol.76, (1) 0741-5400 25-29.
10.1189/jlb.1103552
Flower RJ (2004). Effects of anti-inflammatory drugs on leucocytes. FUNDAMENTAL & CLINICAL PHARMACOLOGY Vol.18, () 0767-3981 8-8.
Yona S, Buckingham JC, Perretti M et al. (2004). Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages. BRIT J PHARMACOL Vol.142, (5) 0007-1188 890-898.
10.1038/sj.bjp.0705858
John CD, Christian HC, Morris JF et al. (2004). Annexin 1 and the regulation of endocrine function. TRENDS ENDOCRIN MET Vol.15, (3) 1043-2760 103-109.
10.1016/j.tem.2004.02.001
John CD, Christian HC, Morris JF et al. (2003). Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides.. J Neuroendocrinol Vol.15, (10) 0953-8194 946-957.
10.1046/j.1365-2826.2003.01081.x
Paul-Clark MJ, Roviezzo F, Flower RJ et al. (2003). Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands.. J Immunol Vol.171, (6) 0022-1767 3245-3252.
Flower RJ (2003). Studies on the mechanism of action of anti-inflammatory drugs. A paper in honour of John Vane.. Thromb Res Vol.110, (5-6) 0049-3848 259-263.
10.1016/S0049-3848(03)00410-9
Gavins FN, Yona S, Kamal AM et al. (2003). Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms.. Blood Vol.101, (10) 0006-4971 4140-4147.
10.1182/blood-2002-11-3411
Croxtall JD, Gilroy DW, Solito E et al. (2003). Attenuation of glucocorticoid functions in an Anx-A1-/- cell line.. Biochem J Vol.371, (Pt 3) 0264-6021 927-935.
10.1042/BJ20021856
Perretti M, Paul-Clark MJ, Mancini L et al. (2003). Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids. DIGEST LIVER DIS Vol.35, () 1590-8658 S41-S48.
10.1016/S1590-8658(03)00051-3
Gavins FNE, Gao JL, Murphy PM et al. (2003). An annexin 1 peptide reduces myocardial ischaemia reperfusion in the mouse. BRITISH JOURNAL OF PHARMACOLOGY Vol.138, () 0007-1188 U9-U9.
Goulding NJ, Rickford AKB, Sherratt KM et al. (2003). Characterisation of a novel glucocorticoid receptor inhuman platelets. BRITISH JOURNAL OF PHARMACOLOGY Vol.138, () 0007-1188 U61-U61.
Solito E, Mulla A, Morris JF et al. (2003). Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase c, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. ENDOCRINOLOGY Vol.144, (4) 0013-7227 1164-1174.
10.1210/en.2002-220592
Gavins FNE, Flower RJ, Perretti M (2003). A Boc-sensitive receptor, distinct from FPR, mediates the anti-inflammatory action of an annexin 1 peptide in the mouse heart. FASEB JOURNAL Vol.17, (5) 0892-6638 A1074-A1074.
Paul-Clark MJ, Getting SJ, Flower RJ et al. (2003). Anti-arthritic properties of an NO-donating glucocorticoid, NCX-1015. FASEB JOURNAL Vol.17, (5) 0892-6638 A1061-A1061.
Getting SJ, Lam CW, Christian HC et al. (2003). Melanocortin agonists possess anti-inflammatory effect in mice with a non-funetional MC1-R (recessive yellow e/e mice). FASEB JOURNAL Vol.17, (5) 0892-6638 A1069-A1069.
Flower RJ (2003). The development of COX2 inhibitors. NAT REV DRUG DISCOV Vol.2, (3) 1474-1776 179-191.
10.1038/nrd.1034
Flower RJ (2003). The development of COX2 inhibitors.. Nat Rev Drug Discov Vol.2, (3) 1474-1776 179-191.
10.1038/nrd1034
Flower RJ, PERRETTI M, Getting SJ et al. (2003). Aberrant inflammatory responses and resistance to glucocorticoids in the annexin 1 -/- mouse. The FASEB Journal Vol.17, () 0892-6638 253-255.
10.1096/fj.02-0239fje
Flower RJ, PERRETTI M, Getting SJ et al. (2003). Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.. J IMMUNOL Vol.170, () 3323-3330.
Yona S, Perretti M, Buckingham JC et al. (2002). Altered degree of activation and steroid inhibition in leukocytes from annexin 1 null mice. BRITISH JOURNAL OF PHARMACOLOGY Vol.137, () 0007-1188 -.
Fiorucci S, Antonelli E, Distrutti E et al. (2002). NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. P NATL ACAD SCI USA Vol.99, (24) 0027-8424 15770-15775.
10.1073/pnas.232583599
Bazan NG, Flower RJ (2002). Medicine - Lipid signals in pain control. NATURE Vol.420, (6912) 0028-0836 135-+.
10.1038/420135a
Getting SJ, Christian HC, Flower RJ et al. (2002). Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. ARTHRITIS RHEUM Vol.46, (10) 0004-3591 2765-2775.
10.1002/art.10526
Hammond RA, Flower RJ, Bryant CE (2002). Complete coding sequence of equine inducible nitric oxide synthase. RES VET SCI Vol.72, (3) 0034-5288 245-245.
10.1053/rvsc.2002.0549
Getting SJ, Flower RJ, Perretti M (2002). A molecular mechanism for the clinical efficacy of ACTH in controlling human gout: activation of melanocortin type 3 receptor. FASEB J Vol.16, (4) 0892-6638 A591-A591.
Gavins FNE, Gao JL, Murphy PM et al. (2002). Annexin 1 peptide inhibits ischaemia reperfusion (IR)-induced leukocyte adhesion and emigration: Receptors involved. FASEB J Vol.16, (4) 0892-6638 A598-A599.
Getting SJ, Flower RJ, Perretti M (2002). Activation of melanocortin type 3 receptor as a novel mechanism for ACTH efficacy in gouty arthritis. BRIT J PHARMACOL Vol.135, () 0007-1188 -.
Gavins FNE, Gao J, Murphy PM et al. (2002). Annexin 1 peptide protects against ischaemia reperfusion in the mouse mesentery. BRIT J PHARMACOL Vol.135, () 0007-1188 -.
FLOWER RJ, Gilroy DW, Croxtall JD et al. (2002). Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells.. Br J Pharmacol. Vol.135, (2) 0007-1188 511-519.
10.1038/sj.bjp.0704474
FLOWER RJ, Croxtall JD, McKay DT et al. (2002). Investigation into the involvement of phospholipases A2 and map kinases in modulation of AA release and cell growth in A549 cells.. Adv Exp Med Biol. Vol.507, () 33-40.
FLOWER RJ, Perretti M, Paul-Clark MJ et al. (2002). Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis.. Proc Natl Acad Sci USA. Vol.99, (3) 1677-1682.
10.1073/pnas.022641099
Flower RJ, Perretti M, HANNON R et al. (2002). The annexin 1 knockout mouse: what it tells us about the inflammatory response. J Physiol Pharmacol Vol.53, (4) 541-553.
La M, Tailor A, D'Amico M et al. (2001). Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment.. Eur J Pharmacol Vol.429, (1-3) 0014-2999 263-278.
10.1016/S0014-2999(01)01325-5
La M, D'Amico M, Bandiera S et al. (2001). Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action. FASEB J Vol.15, (12) 0892-6638 2247-2256.
10.1096/fj.01-0196com
La M, Bandiera S, Flower RJ et al. (2001). Annexin-1-derived peptides protect against myocardial ischaemia reperfusion injury. BRIT J PHARMACOL Vol.133, () 0007-1188 U20-U20.
John CD, Solito E, Mulla A et al. (2001). Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism.. BRIT J PHARMACOL Vol.133, () 0007-1188 U20-U20.
Getting SJ, Flower RJ, Perretti M (2001). Effect of melanocortin agonists on joint inflammation. BRIT J PHARMACOL Vol.133, () 0007-1188 U19-U19.
Goulding NJ, Rajakulendran S, Goulding PN et al. (2001). Monocyte CD163 expression is regulated by glucocorticoids and lipopolysaccharide but not by chemokines. BRIT J PHARMACOL Vol.133, () 0007-1188 U100-U100.
Allcock GH, Allegra M, Flower RJ et al. (2001). Neutrophil accumulation induced by bacterial lipopolysaccharide: effects of dexamethasone and annexin 1.. Clin Exp Immunol Vol.123, (1) 0009-9104 62-67.
10.1046/j.1365-2249.2001.01370.x
FLOWER RJ, Perretti M, Christian HC et al. (2001). Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression.. Am J Pathol. Vol.158, (2) 603-615.
10.1016/S0002-9440(10)64002-3
FLOWER RJ, Christian HC, Morris JF et al. (2001). Opposing influences of glucocorticoids and interleukin-1beta on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1.. Br J Pharmacol. Vol.134, (4) 887-895.
10.1038/sj.bjp.0704324
Paul-Clark M, Del Soldato P, Fiorucci S et al. (2000). 21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties. BRIT J PHARMACOL Vol.131, (7) 0007-1188 1345-1354.
10.1038/sj.bjp.0703704
Taylor AD, Christian HC, Morris JF et al. (2000). Evidence from immunoneutralization and antisense studies that the inhibitory actions of glucocorticoids on growth hormone release in vitro require annexin 1 (lipocortin 1). BRIT J PHARMACOL Vol.131, (7) 0007-1188 1309-1316.
10.1038/sj.bjp.0703694
D'Amico M, Di Filippo C, La M et al. (2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment.. FASEB J Vol.14, (13) 0892-6638 1867-1869.
10.1096/fj.99-0602fje
Oliani SM, Christian HC, Manston J et al. (2000). An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: modulation by inflammation and dexamethasone.. Lab Invest Vol.80, (9) 0023-6837 1429-1438.
Choudhury QG, McKay DT, Flower RJ et al. (2000). Investigation into the involvement of phospholipases A(2) and MAP kinases in modulation of AA release and cell growth in A549 cells.. Br J Pharmacol Vol.131, (2) 0007-1188 255-265.
10.1038/sj.bjp.0703573
Taylor AD, Philip JG, John CD et al. (2000). Annexin 1 (Lipocortin 1) mediates the glucocorticoid inhibition of cyclic adenosine 3 ',5 '-monophosphate-stimulated prolactin secretions. ENDOCRINOLOGY Vol.141, (6) 0013-7227 2209-2219.
10.1210/en.141.6.2209
Lim LHK, Flower RJ, Perretti M et al. (2000). Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils - Characterization and functional relevance. AM J RESP CELL MOL Vol.22, (6) 1044-1549 693-701.
Croxtall JD, Choudhury Q, Flower RJ (2000). Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism.. Br J Pharmacol Vol.130, (2) 0007-1188 289-298.
10.1038/sj.bjp.0703272
Canaider S, Solito E, de Coupade C et al. (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I).. Life Sci Vol.66, (18) 0024-3205 PL265-PL270.
10.1016/S0024-3205(00)00500-2
Getting SJ, Flower RJ, Perretti M (2000). A natural agonist of the MC3 receptor inhibits acute inflammation. BRIT J PHARMACOL Vol.129, () 0007-1188 U120-U120.
Perretti M, Christian H, Wheller SK et al. (2000). Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. CELL BIOL INT Vol.24, (3) 1065-6995 163-174.
10.1006/cbir.1999.0468
Allcock GH, Allegra M, Flower RJ et al. (2000). Effect of lipocortin 1 on LPS-induced neutrophil accumulation in the rat. BRIT J PHARMACOL Vol.129, () 0007-1188 U55-U55.
D'Amico M, Di Filippo C, Solito E et al. (2000). Lipocortin 1 inhibits myocardial infarct by reducing local neutrophil infiltration. BRIT J PHARMACOL Vol.129, () 0007-1188 U56-U56.
Paul-Clark MJ, Lim LHK, Del Soldato P et al. (2000). NCX-1015, a novel derivative of prednisolone with enhanced anti-inflammatory activity. BRIT J PHARMACOL Vol.129, () 0007-1188 U56-U56.
Getting SJ, Flower RJ, Perretti M (1999). Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx. INFLAMMATION RESEARCH Vol.48, () 1023-3830 S140-S141.
Tailor A, Tomlinson A, Salas A et al. (1999). Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC.. Gut Vol.45, (5) 0017-5749 705-712.
Lim LHK, Perretti M, Flower RJ et al. (1999). Glucocorticoid hormones reduce integrin expression on murine eosinophils. BRIT J PHARMACOL Vol.128, () 0007-1188 U16-U16.
Christian HC, Flower RJ, Morris JF et al. (1999). Localisation and semi-quantitative measurement of lipocortin 1 in rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy. J NEUROENDOCRINOL Vol.11, (9) 0953-8194 707-714.
Das AM, Ajuebor MN, Flower RJ et al. (1999). Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis. CLIN EXP IMMUNOL Vol.117, (2) 0009-9104 223-229.
10.1046/j.1365-2249.1999.00978.x
Flower RJ (1999). Non-steroidal anti-inflammatory drugs: back to the future. RHEUMATOLOGY Vol.38, (8) 1462-0324 693-696.
10.1093/rheumatology/38.8.693
Getting SJ, Gibbs L, Clark AJL et al. (1999). POMC gene-derived peptides activate melanocortin type 3 receptor or murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J IMMUNOL Vol.162, (12) 0022-1767 7446-7453.
Perretti M, Wheller SK, Flower RJ et al. (1999). Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions. J LEUKOCYTE BIOL Vol.65, (5) 0741-5400 583-589.
Hammond RA, Hannon R, Frean SP et al. (1999). Endotoxin induction of nitric oxide synthase and cyclooxygenase-2 in equine alveolar macrophages. AM J VET RES Vol.60, (4) 0002-9645 426-431.
Getting SJ, Flower RJ, Perretti M (1999). ACTH 4-10 activates melanocortin type 3 receptor to inhibit neutrophil migration. BRIT J PHARMACOL Vol.126, () 0007-1188 U28-U28.
John CD, Cover PO, Taylor AD et al. (1999). Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26. BRIT J PHARMACOL Vol.126, () 0007-1188 U74-U74.
Brady MM, Philip JG, Wells DJ et al. (1999). Expression and localisation of lipocortin 1 in the rat adrenal gland. BRIT J PHARMACOL Vol.126, () 0007-1188 U74-U74.
Philip JG, Cover PO, Morris JF et al. (1999). Modulation of pituitary hormone release by central or peripheral administration of anti-lipocortin 1 antisera. BRIT J PHARMACOL Vol.126, () 0007-1188 U48-U48.
Ajuebor MN, Das AM, Virag L et al. (1999). Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10. J IMMUNOL Vol.162, (3) 0022-1767 1685-1691.
Euzger HS, Flower RJ, Goulding NJ et al. (1999). Differential modulation of annexin I binding sites on monocytes and neutrophils. MEDIAT INFLAMM Vol.8, (1) 0962-9351 53-62.
de Souza PM, Flower RJ, Goulding NJ (1998). Characterisation of glucocorticoid-induced p155 expression by human monocytes. BRIT J PHARMACOL Vol.125, () 0007-1188 U62-U62.
Lim LH, Solito E, Russo-Marie F et al. (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.. Proc Natl Acad Sci U S A Vol.95, (24) 0027-8424 14535-14539.
10.1073/pnas.95.24.14535
Das AM, Flower RJ, Perretti M (1998). Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo. J LEUKOCYTE BIOL Vol.64, (2) 0741-5400 156-162.
Ajuebor MN, Flower RJ, Perretti M (1998). A functional role of endogenous MCP-1 in IL-1 beta peritonitis. BRIT J PHARMACOL Vol.124, () 0007-1188 U5-U5.
Solito E, de Coupade C, Parente L et al. (1998). IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein.. Cytokine Vol.10, (7) 1043-4666 514-521.
10.1006/cyto.1997.0325
Choudhury Q, Mckay DT, Flower RJ et al. (1998). Modulation of arachidonic acid release and cell growth by phospholipase A(2) inhibitors in A549 cells. BRIT J PHARMACOL Vol.124, () 0007-1188 -.
Flower RJ (1998). Nuclear receptor symposium: Chairman's outline notes. BRIT J PHARMACOL Vol.124, () 0007-1188 U77-U77.
Traverso V, Morris JF, Flower RJ et al. (1998). Lipocortin 1 (annexin 1) in patches associated with the membrane of a lung adenocarcinoma cell line and in the cell cytoplasm. J CELL SCI Vol.111, () 0021-9533 1405-1418.
Solito E, de Coupade C, Parente L et al. (1998). Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1.. Cell Growth Differ Vol.9, (4) 1044-9523 327-336.
Harris HJ, Keating SD, Flower RJ et al. (1998). Generation and characterisation of murine macrophage cell lines transfected with sense and antisense lipocortin-1 (LC-1) cDNA. BRIT J PHARMACOL Vol.123, () 0007-1188 U61-U61.
Croxtall JD, Choudhury Q, Flower RJ (1998). Inhibitory effect of peptides derived from the N-terminus of lipocortin 1 on arachidonic acid release and proliferation in the A549 cell line: identification of E-Q-E-Y-V as a crucial component.. Br J Pharmacol Vol.123, (5) 0007-1188 975-983.
10.1038/sj.bjp.0701679
Philip JG, Flower RJ, Buckingham JC (1998). Blockade of the classical pathway of protein secretion does not affect the cellular exportation of lipocortin 1. REGUL PEPTIDES Vol.73, (2) 0167-0115 133-139.
10.1016/S0167-0115(97)01077-X
Bryant CE, Perretti M, Flower RJ (1998). Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo - A possible role for lipocortin 1. BIOCHEM PHARMACOL Vol.55, (3) 0006-2952 279-285.
10.1016/S0006-2952(97)00462-0
Ajuebor MN, Flower RJ, Hannon R et al. (1998). Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J LEUKOCYTE BIOL Vol.63, (1) 0741-5400 108-116.
Croxtall JD, White JO, Choudhury Q et al. (1998). Tamoxifen inhibits the release of arachidonic acid in estrogen receptor negative A549 cells. FOURTH INTERNATIONAL CONGRESS ON ESSENTIAL FATTY ACIDS AND EICOSANOIDS Vol., () 299-302.
Christian HC, Taylor AD, Flower RJ et al. (1997). Characterization and localization of lipocortin 1-binding sites on rat anterior pituitary cells by fluorescence-activated cell analysis/sorting and electron microscopy. ENDOCRINOLOGY Vol.138, (12) 0013-7227 5341-5351.
10.1210/en.138.12.5341
Croxtall JD, Choudhury Q, White JO et al. (1997). Tamoxifen inhibits the release of arachidonic acid stimulated by thapsigargin in estrogen receptor-negative A549 cells. BBA-LIPID LIPID MET Vol.1349, (3) 0005-2760 275-284.
10.1016/S0005-2760(97)00143-4
Cuzzocrea S, Tailor A, Zingarelli B et al. (1997). Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. J IMMUNOL Vol.159, (10) 0022-1767 5089-5097.
Willmott NJ, Choudhury Q, Flower RJ (1997). Effects of dexamethasone and phorbol ester on P2 receptor-coupled Ca2+ signalling and lipocortin 1 presentation in U937 cells.. Br J Pharmacol Vol.122, (6) 0007-1188 1055-1060.
10.1038/sj.bjp.0701490
Buckingham JC, Flower RJ, Kikkert R et al. (1997). Secretion of corticotrophin-releasing hormone and arginine vasopressin by the neonatal rat hypothalamus in vitro: Age-dependent maturation of the responses to cytokines and modulation by glucocorticoids and lipocortin 1. DEV BRAIN DYSFUNCT Vol.10, (6) 1019-5815 482-502.
Szabo C, Lim LHK, Cuzzocrea S et al. (1997). Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. J EXP MED Vol.186, (7) 0022-1007 1041-1049.
10.1084/jem.186.7.1041
Getting SJ, Flower RJ, Parente L et al. (1997). Molecular determinants of monosodium urate crystal-induced murine peritonitis: A role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. J PHARMACOL EXP THER Vol.283, (1) 0022-3565 123-130.
Tailor A, Flower RJ, Perretti M (1997). Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: An intravital microscopy study. J LEUKOCYTE BIOL Vol.62, (3) 0741-5400 301-308.
Das AM, Flower RJ, Perretti M (1997). Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice - Mechanism of action. J IMMUNOL Vol.159, (3) 0022-1767 1466-1473.
Taylor AD, Christian HC, Morris JF et al. (1997). An antisense oligodeoxynucleotide to lipocortin 1 reverses the inhibitory actions of dexamethasone on the release of adrenocorticotropin from rat pituitary tissue in vitro. ENDOCRINOLOGY Vol.138, (7) 0013-7227 2909-2918.
10.1210/en.138.7.2909
Ferreira SH, Cunha FQ, Lorenzetti BB et al. (1997). Role of lipocortin-1 in the anti-hyperalgesic actions of dexamethasone. BRIT J PHARMACOL Vol.121, (5) 0007-1188 883-888.
10.1038/sj.bjp.0701211
Philip JG, Flower RJ, Buckingham JC (1997). Glucocorticoids modulate the cellular disposition of lipocortin 1 in the rat brain in vivo and in vitro. NEUROREPORT Vol.8, (8) 0959-4965 1871-1876.
10.1097/00001756-199705260-00016
Das AM, Flower RJ, Hellewell PG et al. (1997). A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. BRIT J PHARMACOL Vol.121, (1) 0007-1188 97-104.
10.1038/sj.bjp.0701122
Tailor A, Flower RJ, Perretti M (1997). Dose-related effect of dexamethasone on leucocyte extravasation. BRIT J PHARMACOL Vol.120, () 0007-1188 P327-P327.
Das AM, Flower RJ, Perretti M (1997). Eotaxin recruits eosinophils in sensitised mice. BRIT J PHARMACOL Vol.120, () 0007-1188 P4-P4.
Getting SJ, Flower RJ, Perretti M (1997). Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. BRIT J PHARMACOL Vol.120, (6) 0007-1188 1075-1082.
10.1038/sj.bjp.0701029
Flower RJ (1997). Making NO bones about it. EQUINE VET J Vol.29, (2) 0425-1644 86-87.
Christian HC, Goulding NJ, Morris JF et al. (1997). Novel method for the detection and estimation of intracellular lipocortin 1 in the anterior pituitary gland by FAC-analysis/sorting. BRIT J PHARMACOL Vol.120, () 0007-1188 P3-P3.
Tailor A, Das AM, Getting SJ et al. (1997). Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes. BIOCHEM BIOPH RES CO Vol.231, (3) 0006-291X 675-678.
10.1006/bbrc.1997.6168
Das AM, Lim LH, Flower RJ et al. (1997). Dexamethasone reduces cell surface levels of CD11b on human eosinophils.. Mediators Inflamm Vol.6, (5-6) 0962-9351 363-367.
10.1080/09629359791505
Flower RJ (1996). New directions in cyclooxygenase research and their implications for NSAID-gastropathy. ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY Vol.28, () 0392-0623 23-27.
Perretti M, Croxtall JD, Wheller SK et al. (1996). Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. NAT MED Vol.2, (11) 1078-8956 1259-1262.
10.1038/nm1196-1259
Collier DJ, Nathan J, Flower RJ et al. (1996). Renal-selective carbonic anhydrase inhibition prevents acute mountain sickness in man. J PHYSIOL-LONDON Vol.497P, () 0022-3751 P30-P31.
Christian HC, Goulding NJ, Kahan M et al. (1996). Detection of lipocortin 1 (LC1) and LC1 binding sites in the rat anterior pituitary gland by fluorescent activated cell analysis/sorting (FACS). BRIT J PHARMACOL Vol.119, () 0007-1188 P61-P61.
Getting SJ, Flower RJ, Perretti M (1996). Dexamethasone inhibits recruitment during acute inflammation via endogenous lipocortin 1. BRIT J PHARMACOL Vol.119, () 0007-1188 P160-P160.
Tailor A, Flower RJ, Perretti M (1996). Intercellular adhesion molecule-1 (ICAM-1) expression on rat monocytes and macrophages is controlled by dexamethasone. BRIT J PHARMACOL Vol.119, () 0007-1188 P59-P59.
Das A, Flower RJ, Perretti M (1996). Modulation of allergen-induced mouse eosinophil migration by dexamethasone in a novel model. BRIT J PHARMACOL Vol.119, () 0007-1188 P58-P58.
Ajuebor MN, Flower RJ, Perretti M (1996). Strict relationship between MCP-1 and monocyte recruitment in the mouse peritoneal cavity. BRIT J PHARMACOL Vol.119, () 0007-1188 P57-P57.
Euzger HS, Perretti M, Flower RJ et al. (1996). The lipocortin-1 binding site on human monocytes is sensitive to proteolytic enzymes. BRIT J PHARMACOL Vol.119, () 0007-1188 P60-P60.
Willmott NJ, Choudhury Q, Flower RJ (1996). Functional importance of the dihydropyridine-sensitive, yet voltage-insensitive store-operated Ca2+ influx of U937 cells.. FEBS Lett Vol.394, (2) 0014-5793 159-164.
10.1016/0014-5793(96)00939-8
Croxtall JD, Choudhury Q, Newman S et al. (1996). Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation.. Biochem Pharmacol Vol.52, (2) 0006-2952 351-356.
10.1016/0006-2952(95)02442-5
Perretti M, Wheller SK, Harris JG et al. (1996). Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1 beta and dexamethasone. BIOCHEM BIOPH RES CO Vol.223, (1) 0006-291X 112-117.
10.1006/bbrc.1996.0854
Perretti M, Flower RJ (1996). Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: Modulation by glucocorticoids and inflammation. BRIT J PHARMACOL Vol.118, (3) 0007-1188 605-610.
Perretti M, Flower RJ (1996). Endogenous lipocortin 1 (LC1) as the effector of a negative feed-back mechanism to control leukocyte emigration.. FASEB J Vol.10, (6) 0892-6638 1922-1922.
Harris JG, Flower RJ, Watanabe K et al. (1996). Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). BIOCHEM BIOPH RES CO Vol.221, (3) 0006-291X 692-696.
10.1006/bbrc.1996.0658
Malcangio M, Bowery NG, Flower RJ et al. (1996). Effect of interleukin-1 beta on the release of substance P from rat isolated spinal cord. EUR J PHARMACOL Vol.299, (1-3) 0014-2999 113-118.
10.1016/0014-2999(95)00845-4
Croxtall JD, Newman SP, Choudhury Q et al. (1996). The concerted regulation of cPLA(2), COX2, and lipocortin 1 expression by IL-1 beta in A549 cells. BIOCHEM BIOPH RES CO Vol.220, (3) 0006-291X 491-495.
10.1006/bbrc.1996.0432
Perretti M, Ahluwalia A, Harris JG et al. (1996). Acute inflammatory response in the mouse: Exacerbation by immunoneutralization of lipocortin 1. BRIT J PHARMACOL Vol.117, (6) 0007-1188 1145-1154.
TAYLOR AD, FLOWER RJ, BUCKINGHAM JC (1995). DEXAMETHASONE INHIBITS THE RELEASE OF TSH FROM THE RAT ANTERIOR-PITUITARY GLAND IN-VITRO BY MECHANISMS DEPENDENT ON DE-NOVO PROTEIN-SYNTHESIS AND LIPOCORTIN-1. J ENDOCRINOL Vol.147, (3) 0022-0795 533-544.
10.1677/joe.0.1470533
BRYANT CE, SMITH D, PAUL A et al. (1995). EFFECT OF DEXAMETHASONE AND BREFELDIN-A ON ACTIVITY AND SUBCELLULAR-LOCALIZATION OF INDUCIBLE NITRIC-OXIDE SYNTHASE. BRIT J PHARMACOL Vol.116, () 0007-1188 P455-P455.
NEWMAN SP, CROXTALL JD, CHOUDHURY Q et al. (1995). IL-1-BETA INDUCES ARACHIDONIC-ACID RELEASE AND CYCLOOXYGENASE-2 EXPRESSION IN A CONCERTED FASHION, BY A COMMON SIGNALING PATHWAY INVOLVING PLC AND PKC. BRIT J PHARMACOL Vol.116, () 0007-1188 P281-P281.
HARRIS HJ, FLOWER RJ (1995). IMMUNOLOGICAL ASSESSMENT OF GLYCOSYLATION SITES IN HUMAN CORTICOSTEROID-BINDING GLOBULIN (CBG). BRIT J PHARMACOL Vol.116, () 0007-1188 P316-P316.
BRYANT CE, PAUL A, CROXTALL JD et al. (1995). LIPOCORTIN-1 SUPPRESSION OF THE LIPOPOLYSACCHARIDE INDUCTION OF INDUCIBLE NITRIC-OXIDE SYNTHASE - COMPARISON WITH THE RESPONSE TO INTERFERON-GAMMA. BRIT J PHARMACOL Vol.116, () 0007-1188 P327-P327.
TAYLOR AD, COWELL AM, FLOWER RJ et al. (1995). DEXAMETHASONE SUPPRESSES THE RELEASE OF PROLACTIN FROM THE RAT ANTERIOR-PITUITARY GLAND BY LIPOCORTIN-1 DEPENDENT AND INDEPENDENT MECHANISMS. NEUROENDOCRINOLOGY Vol.62, (5) 0028-3835 530-542.
10.1159/000127044
JORENS PG, SIBILLE Y, GOULDING NJ et al. (1995). POTENTIAL ROLE OF CLARA CELL PROTEIN, AN ENDOGENOUS PHOSPHOLIPASE A(2) INHIBITOR, IN ACUTE LUNG INJURY. EUR RESPIR J Vol.8, (10) 0903-1936 1647-1653.
10.1183/09031936.95.08101647
PERRETTI M, WHELLER SK, CHOUDHURY Q et al. (1995). SELECTIVE-INHIBITION OF NEUTROPHIL FUNCTION BY A PEPTIDE DERIVED FROM LIPOCORTIN-1 N-TERMINUS. BIOCHEM PHARMACOL Vol.50, (7) 0006-2952 1037-1042.
10.1016/0006-2952(95)00238-U
HARRIS JG, FLOWER RJ, PERRETTI M (1995). ENDOGENOUS CORTICOSTEROIDS MEDIATE THE NEUTROPHILIA CAUSED BY PLATELET-ACTIVATING-FACTOR IN THE MOUSE. EUR J PHARMACOL Vol.283, (1-3) 0014-2999 9-18.
10.1016/0014-2999(95)00274-O
AHLUWALIA A, NEWBOLD P, BRAIN SD et al. (1995). TOPICAL GLUCOCORTICOIDS INHIBIT NEUROGENIC INFLAMMATION - INVOLVEMENT OF LIPOCORTIN-1. EUR J PHARMACOL Vol.283, (1-3) 0014-2999 193-198.
10.1016/0014-2999(95)00350-T
Croxtall JD, Choudhury Q, Tokumoto H et al. (1995). Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids (changed from glucorticoids) inhibit G protein-dependent activation of cPLA2 activity.. Biochem Pharmacol Vol.50, (4) 0006-2952 465-474.
10.1016/0006-2952(95)00156-T
BRYANT CE, PERRETTI M, HARRIS HJ et al. (1995). IMMUNODETECTION OF INDUCIBLE NITRIC-OXIDE SYNTHASE IN RATS AFTER LIPOPOLYSACCHARIDE ADMINISTRATION - CHARACTERIZATION OF A NOVEL ANTIBODY. BRIT J PHARMACOL Vol.115, () 0007-1188 P11-P11.
TAYLOR AD, LOXLEY HD, FLOWER RJ et al. (1995). IMMUNONEUTRALIZATION OF LIPOCORTIN-1 REVERSES THE ACUTE INHIBITORY EFFECTS OF DEXAMETHASONE ON THE HYPOTHALAMO-PITUITARY-ADRENOCORTICAL RESPONSES TO CYTOKINES IN THE RAT IN-VITRO AND IN-VIVO. NEUROENDOCRINOLOGY Vol.62, (1) 0028-3835 19-31.
10.1159/000126984
MANCUSO F, FLOWER RJ, PERRETTI M (1995). LEUKOCYTE TRANSMIGRATION, BUT NOT ROLLING OR ADHESION, IS SELECTIVELY INHIBITED BY DEXAMETHASONE IN THE HAMSTER POST-CAPILLARY VENULE - INVOLVEMENT OF ENDOGENOUS LIPOCORTIN-1. J IMMUNOL Vol.155, (1) 0022-1767 377-386.
SMITH SF, TETLEY TD, DATTA AK et al. (1995). LIPOCORTIN-1 DISTRIBUTION IN BRONCHOALVEOLAR LAVAGE FROM HEALTHY-HUMAN LUNG - EFFECT OF PREDNISOLONE. J APPL PHYSIOL Vol.79, (1) 8750-7587 121-128.
HARRIS JG, FLOWER RJ, PERRETTI M (1995). ALTERATION OF NEUTROPHIL TRAFFICKING BY A LIPOCORTIN-1 N-TERMINUS PEPTIDE. EUR J PHARMACOL Vol.279, (2-3) 0014-2999 149-157.
10.1016/0014-2999(95)00145-B
WU CC, CROXTALL JD, PERRETTI M et al. (1995). LIPOCORTIN-1 MEDIATES THE INHIBITION BY DEXAMETHASONE OF THE INDUCTION BY ENDOTOXIN OF NITRIC-OXIDE SYNTHASE IN THE RAT. P NATL ACAD SCI USA Vol.92, (8) 0027-8424 3473-3477.
10.1073/pnas.92.8.3473
PERRETTI M, WHELLER SK, MANCUSO F et al. (1995). DETECTION OF INTRACELLULAR LIPOCORTIN-1 IN MOUSE PERIPHERAL-BLOOD LEUKOCYTES BY FLOW-CYTOMETRY. BRIT J PHARMACOL Vol.114, () 0007-1188 P60-P60.
HARRIS JG, FLOWER RJ, PERRETTI M (1995). EFFECT OF A LIPOCORTIN-1 N-TERMINUS PEPTIDE ON NEUTROPHIL KINETICS IN COMPARISON WITH SIALIDASE, FUCOIDIN AND AN ANTIBODY TO CD11B. BRIT J PHARMACOL Vol.114, () 0007-1188 P216-P216.
MANCUSO F, FLOWER RJ, PERRETTI M (1995). LIPOCORTIN-1 MEDIATES THE EFFECT OF DEXAMETHASONE ON LEUKOCYTE BEHAVIOR IN THE HAMSTER-CHEEK POUCH POST-CAPILLARY VENULE. BRIT J PHARMACOL Vol.114, () 0007-1188 P218-P218.
HAGUE D, FLOWER RJ, GOULDING NJ et al. (1995). LIPOPOLYSACCHARIDE REDUCES LIPOCORTIN-1 BINDING TO RAT PERITONEAL-MACROPHAGES. BRIT J PHARMACOL Vol.114, () 0007-1188 P217-P217.
TAYLOR AD, FLOWER RJ, BUCKINGHAM JC (1995). MODULATION OF PROLACTIN-RELEASE IN-VITRO AND IN-VIVO BY DEXAMETHASONE, LIPOCORTIN-1 (LC1). BRIT J PHARMACOL Vol.114, () 0007-1188 P63-P63.
MIOTLA JM, PERRETTI M, FLOWER RJ et al. (1995). SUPPRESSION OF EXPERIMENTAL ACUTE LUNG INJURY IN THE MOUSE BY DEXAMETHASONE AND THE ROLE OF LIPOCORTIN-1. BRIT J PHARMACOL Vol.114, () 0007-1188 P62-P62.
AHLUWALIA A, NEWBOLD P, FLOWER RJ (1995). TOPICAL GLUCOCORTICOIDS INHIBIT NEUROGENIC INFLAMMATION - INVOLVEMENT OF LIPOCORTIN-1. BRIT J PHARMACOL Vol.114, () 0007-1188 P61-P61.
PERRETTI M, WHELLER SK, FLOWER RJ (1995). REDUCTION OF LIPOCORTIN LEVELS IN ACTIVATED NEUTROPHILS. FASEB J Vol.9, (4) 0892-6638 A1042-A1042.
PERRETTI M, FLOWER RJ (1995). Anti-inflammatory lipocortin-derived peptides. NOVEL MOLECULAR APPROACHES TO ANTI-INFLAMMATORY THERAPY Vol.46, () 0379-0363 131-138.
PEERS SH, DUNCAN GS, FLOWER RJ et al. (1995). ENDOGENOUS CORTICOSTEROIDS MODULATE LYMPHOPROLIFERATION AND SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE BROWN-NORWAY RAT. INT ARCH ALLERGY IMM Vol.106, (1) 1018-2438 20-24.
FLOWER RJ (1995). New frontiers in the pharmacotherapy of inflammation. NOVEL MOLECULAR APPROACHES TO ANTI-INFLAMMATORY THERAPY Vol.46, () 0379-0363 169-178.
CROXTALL JD, FLOWER RJ (1994). ANTISENSE OLIGONUCLEOTIDES TO HUMAN LIPOCORTIN-1 INHIBIT GLUCOCORTICOID-INDUCED INHIBITION OF A549 CELL-GROWTH AND EICOSANOID RELEASE. BIOCHEM PHARMACOL Vol.48, (9) 0006-2952 1729-1734.
10.1016/0006-2952(94)90458-8
AHLUWALIA A, MOHAMED RW, FLOWER RJ (1994). INDUCTION OF LIPOCORTIN-1 BY TOPICAL STEROID IN RAT SKIN. BIOCHEM PHARMACOL Vol.48, (8) 0006-2952 1647-1654.
10.1016/0006-2952(94)90210-0
NEWMAN SP, FLOWER RJ, CROXTALL JD (1994). DEXAMETHASONE SUPPRESSION OF IL-1-BETA-INDUCED CYCLOOXYGENASE-2 EXPRESSION IS NOT MEDIATED BY LIPOCORTIN-1 IN A549 CELLS. BIOCHEM BIOPH RES CO Vol.202, (2) 0006-291X 931-939.
10.1006/bbrc.1994.2019
PERRETTI M, HARRIS JG, FLOWER RJ (1994). A ROLE FOR ENDOGENOUS HISTAMINE IN INTERLEUKIN-8-INDUCED NEUTROPHIL INFILTRATION INTO MOUSE AIR-POUCH - INVESTIGATION OF THE MODULATORY ACTION OF SYSTEMIC AND LOCAL DEXAMETHASONE. BRIT J PHARMACOL Vol.112, (3) 0007-1188 801-808.
PERRETTI M, FLOWER RJ (1994). CYTOKINES, GLUCOCORTICOIDS AND LIPOCORTINS IN THE CONTROL OF NEUTROPHIL MIGRATION. PHARMACOL RES Vol.30, (1) 1043-6618 53-59.
10.1016/1043-6618(94)80087-1
BUCKINGHAM JC, LOXLEY HD, TAYLOR AD et al. (1994). CYTOKINES, GLUCOCORTICOIDS AND NEUROENDOCRINE FUNCTION. PHARMACOL RES Vol.30, (1) 1043-6618 35-42.
10.1016/1043-6618(94)80085-5
MANCUSO F, PERRETTI M, FLOWER RJ (1994). INVESTIGATION OF DEXAMETHASONE EFFECTS ON LEUKOCYTE BEHAVIOR USING THE HAMSTER-CHEEK POUCH TECHNIQUE. BRIT J PHARMACOL Vol.112, () 0007-1188 U82-U82.
HARRIS JG, PERRETTI M, FLOWER RJ (1994). ROLE OF ENDOGENOUS CORTICOSTERONE IN PLATELET-ACTIVATING FACTOR-INDUCED NEUTROPHILIA IN THE MOUSE. BRIT J PHARMACOL Vol.112, () 0007-1188 U48-U48.
AHLUWALIA A, FLOWER RJ (1994). CHARACTERIZATION OF CAPSAICIN-INDUCED VASODILATION OF THE PERFUSED RABBIT EAR AND ITS MODULATION BY DEXAMETHASONE. BRIT J PHARMACOL Vol.112, () 0007-1188 U104-U104.
HARRIS JG, PERRETTI M, FLOWER RJ (1994). HISTAMINE COOPERATES WITH INTERLEUKIN-8 TO INDUCE NEUTROPHIL ACCUMULATION INTO THE MOUSE AIR-POUCH. BRIT J PHARMACOL Vol.112, () 0007-1188 U12-U12.
TAYLOR AD, LOXLEY HD, PERRETTI M et al. (1994). IMMUNONEUTRALIZATION OF LIPOCORTIN-1 REVERSES THE INHIBITORY ACTIONS OF DEXAMETHASONE ON HYPOTHALAMO-PITUITARY-ADRENOCORTICAL (HPA) FUNCTION IN-VITRO AND IN-VIVO. BRIT J PHARMACOL Vol.112, () 0007-1188 U11-U11.
SMITH SF, DATTA AK, SMITH T et al. (1994). LIPOCORTIN-1 LEVELS IN LUNG LAVAGE FLUIDS COLLECTED FROM HEALTHY-VOLUNTEERS BEFORE AND AFTER TAKING EXOGENOUS GLUCOCORTICOIDS. BRIT J PHARMACOL Vol.112, () 0007-1188 U14-U14.
TOKUMOTO H, CROXTALL JD, FLOWER RJ (1994). DIFFERENTIAL ROLE OF EXTRACELLULAR AND INTRACELLULAR CALCIUM IN BRADYKININ AND INTERLEUKIN-1-ALPHA STIMULATION OF ARACHIDONIC-ACID RELEASE FROM A549 CELLS. BBA-LIPID LIPID MET Vol.1211, (3) 0005-2760 301-309.
10.1016/0005-2760(94)90154-6
FLOWER RJ, ROTHWELL NJ (1994). LIPOCORTIN-1 - CELLULAR MECHANISMS AND CLINICAL RELEVANCE. TRENDS PHARMACOL SCI Vol.15, (3) 0165-6147 71-76.
10.1016/0165-6147(94)90281-X
PRUZANSKI W, GOULDING NJ, FLOWER RJ et al. (1994). CIRCULATING GROUP-II PHOSPHOLIPASE A(2) ACTIVITY AND ANTILIPOCORTIN ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS - CORRELATIVE STUDY WITH DISEASE-ACTIVITY. J RHEUMATOL Vol.21, (2) 0315-162X 252-257.
Croxtall JD, Emmas C, White JO et al. (1994). Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells.. Biochem Pharmacol Vol.47, (2) 0006-2952 197-202.
10.1016/0006-2952(94)90006-X
HARRIS HJ, FLOWER RJ (1994). ANTISERA WHICH DISTINGUISH THE STRESSED AND RELAXED FORMS OF CORTICOSTEROID-BINDING GLOBULIN. BRIT J PHARMACOL Vol.111, () 0007-1188 P281-P281.
TAYLOR AD, LOXLEY HD, FLOWER RJ et al. (1994). LIPOCORTIN-1 AND HYPOTHALAMOPITUITARY FUNCTION IN THE RAT. BRAIN CORTICOSTEROID RECEPTORS Vol.746, () 0077-8923 441-445.
TAYLOR AD, LOXLEY HD, FLOWER RJ et al. (1994). THE ROLE OF LIPOCORTIN-1 (LC1) IN THE STEROID FEEDBACK-CONTROL OF HYPOTHALAMO-PITUITARY-ADRENOCORTICAL FUNCTION - IN-VIVO STUDIES. BRAIN CORTICOSTEROID RECEPTORS Vol.746, () 0077-8923 446-448.
MITCHELL JA, AKARASEREENONT P, THIEMERMANN C et al. (1993). SELECTIVITY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS AS INHIBITORS OF CONSTITUTIVE AND INDUCIBLE CYCLOOXYGENASE. P NATL ACAD SCI USA Vol.90, (24) 0027-8424 11693-11697.
10.1073/pnas.90.24.11693
ELDERFIELD AJ, BOLTON C, FLOWER RJ (1993). LIPOCORTIN-1 (ANNEXIN-1) IMMUNOREACTIVITY IN THE CERVICAL SPINAL-CORD OF LEWIS RATS WITH ACUTE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS. J NEUROL SCI Vol.119, (2) 0022-510X 146-153.
10.1016/0022-510X(93)90127-K
PERRETTI M, AHLUWALIA A, HARRIS JG et al. (1993). LIPOCORTIN-1 FRAGMENTS INHIBIT NEUTROPHIL ACCUMULATION AND NEUTROPHIL-DEPENDENT EDEMA IN THE MOUSE - A QUALITATIVE COMPARISON WITH AN ANTI-CD11B MONOCLONAL-ANTIBODY. J IMMUNOL Vol.151, (8) 0022-1767 4306-4314.
TAYLOR AD, FLOWER RJ, BUCKINGHAM JC (1993). MODULATION OF THE RELEASE OF PROLACTIN AND THYROTROPIN BY DEXAMETHASONE AND LIPOCORTIN-1. BRIT J PHARMACOL Vol.110, () 0007-1188 P177-P177.
PERRETTI M, DUNCAN GS, FLOWER RJ et al. (1993). SERUM CORTICOSTERONE, INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR IN RAT EXPERIMENTAL ENDOTOXEMIA - COMPARISON BETWEEN LEWIS AND WISTAR STRAINS. BRIT J PHARMACOL Vol.110, (2) 0007-1188 868-874.
KIKKERT R, LOXLEY HD, TAYLOR AD et al. (1993). TISSUE-SPECIFIC CHANGES IN THE EXPRESSION OF LIPOCORTIN-1 (LC1) DURING POSTNATAL-DEVELOPMENT IN THE RAT. BRIT J PHARMACOL Vol.110, () 0007-1188 P176-P176.
TOKUMOTO H, CROXTALL JD, CHOUDHURY Q et al. (1993). PHOSPHOLIPASE-A(2)-INDUCED STIMULATION OF A549 LUNG ADENOCARCINOMA CELL-LINE PROLIFERATION. BIOCHIM BIOPHYS ACTA Vol.1169, (3) 0006-3002 236-242.
10.1016/0005-2760(93)90246-6
PERRETTI M, AHLUWALIA A, FLOWER RJ et al. (1993). ENDOGENOUS TACHYKININS PLAY A ROLE IN IL-1-INDUCED NEUTROPHIL ACCUMULATION - INVOLVEMENT OF NK-1 RECEPTORS. IMMUNOLOGY Vol.80, (1) 0019-2805 73-77.
PEERS SH, DUNCAN GS, FLOWER RJ (1993). DEVELOPMENT OF SPECIFIC ANTIBODY AND IN-VIVO RESPONSE TO ANTIGEN IN DIFFERENT RAT STRAINS - EFFECT OF DEXAMETHASONE AND IMPORTANCE OF ENDOGENOUS CORTICOSTEROIDS. AGENTS ACTIONS Vol.39, (3-4) 0065-4299 174-181.
10.1007/BF01998971
AHLUWALIA A, FLOWER RJ, PERRETTI M (1993). DUAL-ACTION OF PROSTAGLANDINS (PGS) IN THE MOUSE SKIN EDEMA TEST. BRIT J PHARMACOL Vol.109, () 0007-1188 P5-P5.
LOXLEY HD, COWELL AM, FLOWER RJ et al. (1993). MODULATION OF THE HYPOTHALAMO-PITUITARY-ADRENOCORTICAL RESPONSES TO CYTOKINES IN THE RAT BY LIPOCORTIN-1 AND GLUCOCORTICOIDS - A ROLE FOR LIPOCORTIN-1 IN THE FEEDBACK INHIBITION OF CRF-41 RELEASE. NEUROENDOCRINOLOGY Vol.57, (5) 0028-3835 801-814.
10.1159/000126439
PERRETTI M, FLOWER RJ, GOULDING NJ (1993). THE ABILITY OF MURINE LEUKOCYTES TO BIND LIPOCORTIN-1 IS LOST DURING ACUTE-INFLAMMATION. BIOCHEM BIOPH RES CO Vol.192, (2) 0006-291X 345-350.
10.1006/bbrc.1993.1421
CROXTALL JD, WAHEED S, CHOUDHURY Q et al. (1993). N-TERMINAL PEPTIDE-FRAGMENTS OF LIPOCORTIN-1 INHIBIT A549 CELL-GROWTH AND BLOCK EGF-INDUCED STIMULATION OF PROLIFERATION. INT J CANCER Vol.54, (1) 0020-7136 153-158.
10.1002/ijc.2910540124
PERRETTI M, FLOWER RJ, GOULDING NJ (1993). MURINE LEUKOCYTES LOSE LIPOCORTIN-1 BINDING-CAPACITY DURING ACUTE-INFLAMMATION. BRIT J PHARMACOL Vol.108, () 0007-1188 P11-P11.
CIRINO G, CICALA C, SORRENTINO L et al. (1993). ANTIINFLAMMATORY ACTIONS OF AN N-TERMINAL PEPTIDE FROM HUMAN LIPOCORTIN-1. BRIT J PHARMACOL Vol.108, (3) 0007-1188 573-574.
LOXLEY HD, COWELL AM, FLOWER RJ et al. (1993). EFFECTS OF LIPOCORTIN-1 AND DEXAMETHASONE ON THE SECRETION OF CORTICOTROPIN-RELEASING FACTORS IN THE RAT - INVITRO AND INVIVO STUDIES. J NEUROENDOCRINOL Vol.5, (1) 0953-8194 51-61.
10.1111/j.1365-2826.1993.tb00363.x
AHLUWALIA A, FLOWER RJ (1993). INVESTIGATIONS INTO THE MECHANISM OF VASOCONSTRICTOR ACTION OF THE TOPICAL STEROID BETAMETHASONE-17-VALERATE IN THE RAT. BRIT J PHARMACOL Vol.108, (2) 0007-1188 544-548.
PERRETTI M, FLOWER RJ (1993). MODULATION OF IL-1-INDUCED NEUTROPHIL MIGRATION BY DEXAMETHASONE AND LIPOCORTIN-1. J IMMUNOL Vol.150, (3) 0022-1767 992-999.
AHLUWALIA A, FLOWER RJ (1993). EFFECT OF CHRONIC CAPSAICIN AND GUANETHIDINE TREATMENT ON SKIN BLOOD-FLOW OF THE RAT. AGENTS AND ACTIONS Vol.38, () 0065-4299 C16-C18.
10.1007/BF01991123
PERRETTI M, APPLETON I, PARENTE L et al. (1993). PHARMACOLOGY OF INTERLEUKIN-1-INDUCED NEUTROPHIL MIGRATION. AGENTS AND ACTIONS Vol.38, () 0065-4299 C64-C65.
10.1007/BF01991139
DUNCAN GS, PEERS SH, CAREY F et al. (1993). THE LOCAL ANTIINFLAMMATORY ACTION OF DEXAMETHASONE IN THE RAT CARRAGEENAN EDEMA MODEL IS REVERSED BY AN ANTISERUM TO LIPOCORTIN-1. BRIT J PHARMACOL Vol.108, (1) 0007-1188 62-65.
AHLUWALIA A, FLOWER RJ (1993). TOPICAL BETAMETHASONE-17-VALERATE INHIBITS HEAT-INDUCED VASODILATATION IN MAN. BRIT J DERMATOL Vol.128, (1) 0007-0963 45-48.
10.1111/j.1365-2133.1993.tb00146.x
MURPHY CT, PEERS SH, FORDER RA et al. (1992). EVIDENCE FOR THE PRESENCE AND LOCATION OF ANNEXINS IN HUMAN PLATELETS. BIOCHEM BIOPH RES CO Vol.189, (3) 0006-291X 1739-1746.
10.1016/0006-291X(92)90279-T
DUNCAN GS, PEERS SH, PARENTE L et al. (1992). EFFECTS OF LIPOCORTIN-RELATED PEPTIDES UPON NEUTROPHIL BEHAVIOR INVITRO. BRIT J PHARMACOL Vol.107, () 0007-1188 P419-P419.
LOXLEY HD, FLOWER RJ, BUCKINGHAM JC (1992). INHIBITORY EFFECTS OF HUMAN RECOMBINANT LIPOCORTIN-1 AND DEXAMETHASONE ON THE SECRETION OF CORTICOTROPIN RELEASING FACTOR-41 (CRF-41) IN THE RAT. BRIT J PHARMACOL Vol.107, () 0007-1188 P307-P307.
PEERS SH, DUNCAN GS, FLOWER RJ et al. (1992). RELEASE OF INTERLEUKIN-1 (IL-1), TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) ACTIVITY AND CORTICOSTERONE (CCS) IN EXPERIMENTAL ENDOTOXEMIA IN LEWIS AND WISTAR RATS. BRIT J PHARMACOL Vol.107, () 0007-1188 P258-P258.
TAYLOR AD, FLOWER RJ, BUCKINGHAM JC (1992). THE INHIBITION BY LIPOCORTIN 1 OF ACTH-SECRETION EVOKED INVITRO BY THE CALCIUM-CHANNEL AGONIST, BAY K8644. BRIT J PHARMACOL Vol.107, () 0007-1188 P306-P306.
LOXLEY HD, FLOWER RJ, BUCKINGHAM JC (1992). A COMPARISON OF THE EFFECTS OF DEXAMETHASONE AND LIPOCORTIN-1 (LC1) ON HYPOTHALAMOPITUITARY-ADRENOCORTICAL (HPA) FUNCTION IN THE RAT. J ENDOCRINOL Vol.135, () 0022-0795 P49-P49.
PODGORSKI MR, GOULDING NJ, HALL ND et al. (1992). AUTOANTIBODIES TO LIPOCORTIN-1 ARE ASSOCIATED WITH IMPAIRED GLUCOCORTICOID RESPONSIVENESS IN RHEUMATOID-ARTHRITIS. J RHEUMATOL Vol.19, (11) 0315-162X 1668-1671.
DOUGLAS GJ, FLOWER RJ, PARENTE L et al. (1992). PEPTIDE-204-212 OF LIPOCORTIN-5 INHIBITS THE GENERATION OF A PROSTACYCLIN-LIKE FACTOR FROM RAT AORTA PREPARATIONS INVITRO. PROSTAGLANDINS Vol.44, (5) 0090-6980 381-388.
10.1016/0090-6980(92)90134-F
TAYLOR AD, FLOWER RJ, BUCKINGHAM JC (1992). THE INFLUENCE OF PROTEIN-SYNTHESIS INHIBITORS ON THE REGULATORY ACTIONS OF DEXAMETHASONE ON THE EXPRESSION OF LIPOCORTIN-1 AND THE INHIBITION OF ACTH-SECRETION BY RAT ANTERIOR-PITUITARY TISSUE INVITRO. J ENDOCRINOL Vol.135, () 0022-0795 O17-O17.
PERRETTI M, CROXTALL JD, FLOWER RJ (1992). ENDOGENOUS LIPOCORTIN-1 MEDIATES DEXAMETHASONE INHIBITION OF INTERLEUKIN-1-INDUCED NEUTROPHIL ACCUMULATION INVIVO. BRIT J PHARMACOL Vol.107, () 0007-1188 P77-P77.
Flower RJ (1992). Wither the beauty's transient flower.. Curr Biol Vol.2, (9) 0960-9822 501-502.
FLOWER RJ (1992). LIPOCORTIN - WHAT IS IT AND WHAT DOES IT MEAN. BRIT J RHEUMATOL Vol.31, (8) 0263-7103 506-507.
ELDERFIELD AJ, NEWCOMBE J, BOLTON C et al. (1992). LIPOCORTINS (ANNEXINS) 1, 2, 4 AND 5 ARE INCREASED IN THE CENTRAL-NERVOUS-SYSTEM IN MULTIPLE-SCLEROSIS. J NEUROIMMUNOL Vol.39, (1-2) 0165-5728 91-100.
10.1016/0165-5728(92)90178-N
TAYLOR AD, ANTONI F, CROXTALL JD et al. (1992). MODULATION OF CORTICOTROPIN (ACTH) RELEASE INVITRO BY LIPOCORTIN 1 (LC-1) AND DEXAMETHASONE. BRIT J PHARMACOL Vol.106, () 0007-1188 P4-P4.
LOXLEY HD, TAYLOR AD, FLOWER RJ et al. (1992). MODULATION OF THE HYPOTHALAMO-PITUITARY-GONADAL AXIS BY LIPOCORTIN-1. BRIT J PHARMACOL Vol.106, () 0007-1188 P109-P109.
PERRETTI M, APPLETON I, GHIARA P et al. (1992). NEUTROPHIL RECRUITMENT INTO MOUSE AIR-POUCH BY INTERLEUKIN-1-BETA IS MEDIATED BY TYPE-1 RECEPTORS. BRIT J PHARMACOL Vol.106, () 0007-1188 P104-P104.
AHLUWALIA A, PEERS SH, FLOWER RJ (1992). STEROID INHIBITION OF EDEMA FORMATION IN THE RAT SKIN. BRIT J PHARMACOL Vol.106, (3) 0007-1188 628-631.
AHLUWALIA A, FLOWER RJ (1992). TOPICAL STEROIDS AND ACE INHIBITORS - A COMMON LINK. BRIT J PHARMACOL Vol.106, () 0007-1188 P5-P5.
CROXTALL JD, FLOWER RJ (1992). LIPOCORTIN-1 MEDIATES DEXAMETHASONE-INDUCED GROWTH ARREST OF THE A549 LUNG ADENOCARCINOMA CELL-LINE. P NATL ACAD SCI USA Vol.89, (8) 0027-8424 3571-3575.
10.1073/pnas.89.8.3571
DASILVA JAP, PEERS SH, FLOWER RJ et al. (1992). SEX-HORMONES INFLUENCE THE HPA AXIS ANTIINFLAMMATORY RESPONSE. BRIT J RHEUMATOL Vol.31, () 0263-7103 111-111.
COWELL AM, FLOWER RJ, BUCKINGHAM JC (1991). STUDIES ON THE ROLES OF PHOSPHOLIPASE-A2 AND EICOSANOIDS IN THE REGULATION OF CORTICOTROPIN SECRETION BY RAT PITUITARY-CELLS INVITRO. J ENDOCRINOL Vol.130, (1) 0022-0795 21-32.
10.1677/joe.0.1300021
STEVENS TRJ, SMITH SF, SMITH T et al. (1991). LIPOCORTIN-1 ANTIBODIES IN INFLAMMATORY BOWEL-DISEASE. GUT Vol.32, (5) 0017-5749 A561-A562.
DAVIDSON J, FLOWER RJ, MILTON AS et al. (1991). ANTIPYRETIC ACTIONS OF HUMAN RECOMBINANT LIPOCORTIN-1. BRIT J PHARMACOL Vol.102, (1) 0007-1188 7-9.
LOXLEY HD, COWELL AM, COVER PO et al. (1991). THE INFLUENCE OF LIPOCORTIN-1 ON HYPOTHALAMO-PITUITARY-ADRENOCORTICAL (HPA) FUNCTION IN THE RAT INVIVO AND INVITRO. J PHYSIOL-LONDON Vol.438, () 0022-3751 P51-P51.
VANE JR, FLOWER RJ, BOTTING RM (1990). HISTORY OF ASPIRIN AND ITS MECHANISM OF ACTION. STROKE Vol.21, (12) 0039-2499 12-23.
BOLTON C, ELDERFIELD AJ, FLOWER RJ (1990). THE DETECTION OF LIPOCORTINS 1, 2 AND 5 IN CENTRAL-NERVOUS-SYSTEM TISSUES FROM LEWIS RATS WITH ACUTE EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS. J NEUROIMMUNOL Vol.29, (1-3) 0165-5728 173-181.
10.1016/0165-5728(90)90160-O
BROWNING J, PEPINSKY B, WALLNER B et al. (1990). TOO SOON FOR CONSENSUS. NATURE Vol.346, (6282) 0028-0836 324-324.
10.1038/346324a0
SMITH SF, GOULDING NJ, GODOLPHIN JL et al. (1990). AN ASSAY FOR THE ASSESSMENT OF LIPOCORTIN-1 LEVELS IN HUMAN LUNG LAVAGE FLUID. J IMMUNOL METHODS Vol.131, (1) 0022-1759 119-125.
10.1016/0022-1759(90)90241-M
GOULDING NJ, GODOLPHIN JL, SHARLAND PR et al. (1990). ANTIINFLAMMATORY LIPOCORTIN-1 PRODUCTION BY PERIPHERAL-BLOOD LEUKOCYTES IN RESPONSE TO HYDROCORTISONE. LANCET Vol.335, (8703) 0140-6736 1416-1418.
10.1016/0140-6736(90)91445-G
FLOWER RJ (1990). LIPOCORTIN. CYTOKINES AND LIPOCORTINS IN INFLAMMATION AND DIFFERENTIATION Vol.349, () 11-25.

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Roderick Flower
Professor of Biochemical Pharmacology
Centre for Biochemical Pharmacology
William Harvey Research Institute
Barts and The London, Queen Mary's School of Medicine and Dentistry
John Vane Science Centre
Charterhouse Square
London, EC1M 6BQ
T: +44 90) 20 7882 8781
F: +44 (0) 20 7882 5655
E: This email address is being protected from spambots. You need JavaScript enabled to view it.

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