I divide my time equally between clinical work and basic science with the aim of conducting translational research. My basic science interests have evolved from my PhD undertaken at UCL where I gained an understanding of platelet and stem cell biology as well as cellular bioenergetics. These interests are now consolidated in my work looking at the mechanisms by which stem cells may improve cardiac function.
My clinical work is directed at interventional cardiology and the management of patients with heart failure and angina who have failed conventional therapy. I am Secretary of the ESC Task force on Stem cells in cardiovascular disease and also Chair the clinical group of the British Cardiac stem cells collaborative set up by Professor John Martin.
These roles have enabled me to design a series of clinical trials that will address some of the outstanding issues surrounding the use of stem cells to treat cardiovascular disease. I also have a major interest in the use of advanced cardiac imaging for translational research and have the role of Lead Clinician for Advanced Cardiac Imaging.
Summary of Research
Anthony Mathur leads a collaborative group with Prof. John Martin (UCL) seeking to address the role of stem cells in the treatment of cardiovascular disease. This partnership has lead to the establishment of the largest series of clinical trials translating the interesting results produced by basic experimentation into relevant therapeutic approaches in man. He now is the PI in one of the first Phase III clinical trials of cell therapy in acute myocardial infarction.
The clinical work is also underpinned by a collaboration with Prof Suzuki (WHRI) to understand the basic mechanisms that are involved in stem cell repair of the heart.
Anthony Mathur’s other research interest is in advanced cardiac imaging and in particular its use to examine mechanistic aspects of translational research. He has assembled a state of the art collection of advanced imaging hardware (cardiac MR, PET/CT, cardiac CT, nuclear perfusion and advanced echo) that is strategically run through a joint imaging board that he chairs.
Overall Professor Mathur’s research in interventional cardiology is targeted at the no-option patient with the aim of developing new techniques and devices to treat patients that fall outside the remit of current recognised
For a full list of publist publications click here
Mathur A, Martin JF (2004). Stem cells and repair of the heart.. Lancet Vol.364, (9429) 183-192.
Martin JF, Kristensen SD, Mathur A et al. (2012). The causal role of megakaryocyte-platelet hyperactivity in acute coronary syndromes. NATURE REVIEWS CARDIOLOGY Vol.9, (11) 1759-5002 658-670.
Bartunek J, Dimmeler S, Drexler H et al. (2006). The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. EUR HEART J Vol.27, (11) 0195-668X 1338-1340. 10.1093/eurheartj.ehi793
Fisher SA, Dorée C, Brunskill SJ et al. (2013). Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis.. PLoS One Vol.8, (6) e64669-.
Clifford DM, Fisher SA, Brunskill SJ et al. (2012). Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes.. PLoS One Vol.7, (5) e37373 10.1371/journal.pone.0037373
BBC News - Bone marrow stem cells give 'some' heart healing
BBC One - Bang Goes the Theory
BBC News - Stem cells used to 'heal' heart attack scars
BBC Viewpoint - Should patients be obliged to take part in research?
BBC Horizon - How to mend a broken heart
Guardian - Test begin on stem cell cure for rare heart disease
European Hospitals - Acute myocardial infarction
BBC News - Stem cells 'give my heart hope'
BBC Newsnight - Reality check for stem cell research
The Naked Scientist - Heart disease and repairing the damaged heart
Dr Anthony Mathur, MD, Phd, FRCP
Clinical Senior Lecturer
William Harvey Research Institute
Centre for Clinical Pharmacology
Barts and the London
Queen Mary's School of Medicine and Dentistry
London, WC1M 6BQ
T: +44 (0) 20 7882 5906
T: +44(0) 20 8983 2448