Patricia Munroe

Patricia Munroe

Patricia graduated with a B.Sc. in Biochemistry, and M.Sc. in Biotechnology from the National University Ireland, Galway. She then worked as a research technician at the Wellcome Trust Research Laboratories for six months before commencing a PhD in cardiovascular genetics at St Bartholomew’s Hospital. Patricia was awarded a PhD in Medicine in 1995, and following a post-doctoral fellowship at University College London (NIH funded), she joined the William Harvey Research Institute as a Lecturer in 1998. In 2007 she was appointed Professor of Molecular Medicine.

Prof Munroe’s research is focused on elucidating the genetic and molecular basis of hypertension and cardiac arrhythmias. She co-leads several international complex genetic disease consortia. Using meta-analysis of genome-wide association studies (GWAS) and large-scale candidate gene studies she has discovered over 30 genetic loci associated with hypertension during the past 3 years. She has also contributed data to several gene discoveries for cardiac arrhythmias (QRS, QT and RR) and other complex genetic traits.  Her work is funded by the British Heart Foundation, Medical Research Council, NIHR, The Wellcome Trust and Wellbeing of Women.

Summary of Research

Determining the genetic and molecular basis of hypertension and cardiac arrhythmias

Hypertension is a multifactorial condition, affecting over one billion people worldwide. Recent estimates suggest that increased blood pressure contributes to 50% of coronary heart disease and 69% of stroke morbidity. Genes and lifestyle factors are important contributors, and via large-scale meta-analysis of genome-wide association studies many genetic loci are being discovered. Prolongation of the electrocardiographic QT interval is a risk factor for sudden cardiac death in the general population, and is a life-threatening complication of several medications. Genetic loci that contribute to variability of the QT interval have been discovered, also loci influencing heart rate, and QRS interval have been discovered, these ECG measures are indicators of the electrical function of the heart.

Professor Munroe’s current work is focused on further gene discovery for hypertension and ECG parameters influencing cardiovascular risk (QT, RR and QRS), and characterising the function of newly discovered genes.  We are:

  • Utilising bespoke genotyping arrays (cardiometabochip, IBC and Exome chip) in very large sample sizes via collaboration for further gene discovery.
  • Performing fine mapping studies to locate likely causative genetic variants, and functional studies of candidate genes using molecular biology techniques.
  • Developing a series of gene targeted models for candidate genes derived from GWAS studies. Patricia is the Principle Investigator of the MRC Mouse Network Cardiovascular Trait Consortium.
  • Performing pharmacogenetic studies of hypertension, and working on a multicentre prospective observational study on post-mortem genetic testing to examine the incidence and inheritance patterns of lethal cardiac ion channelopathies in unexplained stillbirth.
A regional association plot of chromosome 11p15.2-15.1.
A regional association plot of chromosome 11p15.2-15.1.

A regional association plot of chromosome 11p15.2-15.1. indicating genetic variants associated with blood pressure.

Members of the Group

Research staff: Shea Addison (Honorary Research Assistant); Kate Witowska (Post-Doctoral Research Assistant); Dr Helen Warren (Post-Doctoral Fellow in Statistical Genetics); Lecturer in Molecular Genetics (vacant);

Support staff: Sue Shaw-Hawkins (Lab manager)

Key Publications

* denotes joint first or last author and # denotes corresponding author.

Johnson T#., Gaunt TR., - 99 co-authors -., Samani NJ., Caulfield MJ., Munroe PB#. ‘Blood Pressure Loci Identified with a Gene-Centric Array’. American Journal of Human Genetics. 2011. Dec 9;89(6):688-700. 

Georg B. Ehret*, Patricia B. Munroe*## then 345 co-authors then Bruce M. Psaty*, Gonçalo R Abecasis*, Aravinda Chakravarti*, Paul Elliott*, Cornelia M. van Duijn*, Christopher Newton-Cheh*#, Daniel Levy*##, Mark J. Caulfield*##, Toby Johnson*. Genetic variants from novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478 (7367):103-9. Voted top 5 paper in CV research and number 1 in stroke by the American Heart Association.

Louise V Wain*, then 246 co-authors- then Patricia B. Munroe*, Bruce Psaty*, Mark J Caulfield*, Dabeeru C Rao*, Martin D Tobin*#, Paul Elliott*#, Cornelia M van Duijn*#. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics 2011; 43(10):1005-11.

Wellcome Trust Case Control Consortium. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature. 2010; 464 (7289):713-20.

Christopher Newton-Cheh*#, then 165 co-authors then Mark Caulfield*#, Patricia B Munroe*#. Eight blood pressure loci identified by genome-wide association study of 34,433 people. Nature Genetics 2009; 41:666-676. Voted American Heart Association Top ten paper in worldwide CV research in 2009.

Caulfield MJ*, Patricia B. Munroe* et al. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med 2008; 5(9): e197.

Wallace C., - 19 others -., Munroe PB#. ‘Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia’. American Journal of Human Genetics 2008, 82(1), (2008), 139-49.

Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-678. Voted Best Scientific Research Paper in the World in 2007 (by both Nature and Science).

PubLists Publications

Yadav S, Cotlarciuc I, Munroe PB et al. (2013). Genome-wide analysis of blood pressure variability and ischemic stroke.. Stroke Vol.44, (10) 2703-2709.
10.1161/STROKEAHA.113.002186
O'Seaghdha CM, Wu H, Yang Q et al. (2013). Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations. PLOS GENETICS Vol.9, (9) 1553-7404 -.
10.1371/journal.pgen.1003796
Munroe PB, Barnes MR, Caulfield MJ (2013). Advances in blood pressure genomics.. Circ Res Vol.112, (10) 1365-1379.
10.1161/CIRCRESAHA.112.300387
Berndt SI, Gustafsson S, Maegi R et al. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. NATURE GENETICS Vol.45, (5) 1061-4036 501-U69.
10.1038/ng.2606
Ganesh SK, Tragante V, Guo W et al. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. HUMAN MOLECULAR GENETICS Vol.22, (8) 0964-6906 1663-1678.
10.1093/hmg/dds555
Verweij N, Mahmud H, Leach IM et al. (2013). Genome-Wide Association Study on Plasma Levels of Midregional-Proadrenomedullin and C-Terminal-Pro-Endothelin-1. HYPERTENSION Vol.61, (3) 0194-911X 602-+.
10.1161/HYPERTENSIONAHA.111.203117
Koettgen A, Albrecht E, Teumer A et al. (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. NATURE GENETICS Vol.45, (2) 1061-4036 145-154.
10.1038/ng.2500
Alvarez-Madrazo S, MacKenzie SM, Davies E et al. (2013). Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension. HYPERTENSION Vol.61, (1) 0194-911X 232-+.
10.1161/HYPERTENSIONAHA.112.200741
Den Hoed M, Eijgelsheim M, Esko T et al. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics Vol.45, (6) 1061-4036 621-631.
10.1038/ng.2610
Randall JC, Winkler TW, Kutalik Z et al. (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics Vol.9, (6) 1553-7390 -.
10.1371/journal.pgen.1003500
Asselbergs FW, Guo Y, van Iperen EPA et al. (2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. AMERICAN JOURNAL OF HUMAN GENETICS Vol.91, (5) 0002-9297 823-838.
10.1016/j.ajhg.2012.08.032
Addison S, Sebire NJ, Taylor AM et al. (2012). High quality genomic DNA extraction from postmortem fetal tissue. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Vol.25, (11) 1476-7058 2467-2469.
10.3109/14767058.2012.704442
Surendran P, Vangjeli C, McCarthy N et al. (2012). Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study. JOURNAL OF HUMAN HYPERTENSION Vol.26, (10) 0950-9240 620-620.
Jamshidi Y, Nolte IM, Dalageorgou C et al. (2012). Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol.60, (9) 0735-1097 841-850.
10.1016/j.jacc.2012.03.031
Friese RS, Ye C, Nievergelt CM et al. (2012). Integrated Computational and Experimental Analysis of the Neuroendocrine Transcriptome in Genetic Hypertension Identifies Novel Control Points for the Cardiometabolic Syndrome. CIRCULATION-CARDIOVASCULAR GENETICS Vol.5, (4) 1942-325X 430-440.
10.1161/CIRCGENETICS.111.962415
Voight BF, Kang HM, Ding J et al. (2012). The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits. PLOS GENETICS Vol.8, (8) 1553-7404 -.
10.1371/journal.pgen.1002793
Saxena R, Elbers CC, Guo Y et al. (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. AMERICAN JOURNAL OF HUMAN GENETICS Vol.90, (3) 0002-9297 410-425.
10.1016/j.ajhg.2011.12.022
Angelakopoulou A, Shah T, Sofat R et al. (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.. Eur Heart J Vol.33, (3) 393-407.
10.1093/eurheartj/ehr225
Salvi E, Kutalik Z, Glorioso N et al. (2012). Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase.. Hypertension Vol.59, (2) 248-255.
10.1161/HYPERTENSIONAHA.111.181990
Scott RA, Lagou V, Welch RP et al. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics Vol., () 1061-4036 -.
10.1038/ng.2385
Johnson T, Gaunt TR, Newhouse SJ et al. (2011). Blood pressure loci identified with a gene-centric array.. Am J Hum Genet Vol.89, (6) 688-700.
10.1016/j.ajhg.2011.10.013
Shah S, Nelson CP, Gaunt TR et al. (2011). Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy.. Circ Cardiovasc Genet Vol.4, (6) 626-635.
10.1161/CIRCGENETICS.111.960203
Chambers JC, Zhang WH, Sehmi J et al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. NAT GENET Vol.43, (11) 1061-4036 1131-U129.
10.1038/ng.970
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB et al. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.. Nature Vol.478, (7367) 103-109.
10.1038/nature10405
Wain LV, Verwoert GC, O'Reilly PF et al. (2011). A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI. J HUM HYPERTENS Vol.25, (10) 0950-9240 647-647.
Wain LV, Verwoert GC, O'Reilly PF et al. (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. NAT GENET Vol.43, (10) 1061-4036 1005-U122.
10.1038/ng.922
McCarthy N, Vangjeli C, Surendran P et al. (2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. J HUM HYPERTENS Vol.25, (10) 0950-9240 625-625.
Ehret G, Munroe PB, Rice K et al. (2011). Sixteen novel loci influence blood pressure and cardiovascular risk. J HUM HYPERTENS Vol.25, (10) 0950-9240 635-636.
Putku M, Kepp K, Org E et al. (2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans.. Hum Mutat Vol.32, (7) 806-814.
10.1002/humu.21508
Johnson AD, Newton-Cheh C, Chasman DI et al. (2011). Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals.. Hypertension Vol.57, (5) 903-910.
10.1161/HYPERTENSIONAHA.110.158667
Lanktree MB, Guo YR, Murtaza M et al. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. AM J HUM GENET Vol.88, (1) 0002-9297 6-18.
10.1016/j.ajhg.2010.11.007
Sotoodehnia N, Isaacs A, de Bakker PIW et al. (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. NAT GENET Vol.42, (12) 1061-4036 1068-U62.
10.1038/ng.716
Speliotes EK, Willer CJ, Berndt SI et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.. Nat Genet Vol.42, (11) 937-948.
10.1038/ng.686
Lovell MJ, Yasin M, Lee KL et al. (2010). Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway.. Atherosclerosis Vol.213, (1) 67-76.
10.1016/j.atherosclerosis.2010.07.045
Tabara Y, Kohara K, Kita Y et al. (2010). Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project.. Hypertension Vol.56, (5) 973-980.
10.1161/HYPERTENSIONAHA.110.153429
Heid IM, Jackson AU, Randall JC et al. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.. Nat Genet Vol.42, (11) 949-960.
10.1038/ng.685
Allen HL, Estrada K, Lettre G et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. NATURE Vol.467, (7317) 0028-0836 832-838.
10.1038/nature09410
Johnson T, Shaw-Hawkins S, Howard P et al. (2010). A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial. J HUM HYPERTENS Vol.24, (10) 0950-9240 694-694.
Hastie CE, Padmanabhan S, Melander O et al. (2010). Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension. J HUM HYPERTENS Vol.24, (10) 0950-9240 687-687.
Padmanabhan S, Melander O, Johnson T et al. (2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.. PLoS Genet Vol.6, (10) e1001177-.
10.1371/journal.pgen.1001177
Munroe PB, Human CVD55 Blood Pressure Consort (2010). Meta-analyses of the HumanCVD55 beadchip discovers new blood pressure genes. J HUM HYPERTENS Vol.24, (10) 0950-9240 696-696.
Teslovich TM, Musunuru K, Smith AV et al. (2010). Biological, clinical and population relevance of 95 loci for blood lipids. NATURE Vol.466, (7307) 0028-0836 707-713.
10.1038/nature09270
Padmanabhan S, Melander O, Johnson T et al. (2010). GENOME WIDE ASSOCIATION STUDY OF BLOOD PRESSURE EXTREMES IDENTIFIES VARIANT IN UMOD ASSOCIATED WITH HYPERTENSION. JOURNAL OF HYPERTENSION Vol.28, () 0263-6352 E237-E237.
Alvarez-Madrazo S, Padmanabhan S, Friel E et al. (2010). Validation of Association of Hypertension at the CYP11B1/B2 Locus in Caucasians.. ENDOCRINE REVIEWS Vol.31, (3) 0163-769X -.
Chambers JC, Zhang WH, Lord GM et al. (2010). Genetic loci influencing kidney function and chronic kidney disease. NAT GENET Vol.42, (5) 1061-4036 373-375.
10.1038/ng.566
Liu JZ, Tozzi F, Waterworth DM et al. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. NAT GENET Vol.42, (5) 1061-4036 436-U75.
10.1038/ng.572
Lindgren CM, Heid IM, Randall JC et al. (2010). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. PLOS GENET Vol.6, (4) 1553-7390 -.
10.1371/journal.pgen.1000508
Craddock N, Hurles ME, Cardin N et al. (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. NATURE Vol.464, (7289) 0028-0836 713-U86.
10.1038/nature08979
Talmud PJ, Drenos F, Shah S et al. (2009). Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip. AM J HUM GENET Vol.85, (5) 0002-9297 628-642.
10.1016/j.ajhg.2009.10.014
Org E, Eyheramendy S, Juhanson P et al. (2009). Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. HUM MOL GENET Vol.18, (12) 0964-6906 2288-2296.
10.1093/hmg/ddp135
Lindgren CM, Heid IM, Randall JC et al. (2009). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. PLOS GENET Vol.5, (6) 1553-7390 -.
10.1371/journal.pgen.1000508
Newton-Cheh C, Johnson T, Gateva V et al. (2009). Genome-wide association study identifies eight loci associated with blood pressure. NAT GENET Vol.41, (6) 1061-4036 666-676.
10.1038/ng.361
Kolz M, Johnson T, Sanna S et al. (2009). Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLOS GENET Vol.5, (6) 1553-7390 -.
10.1371/journal.pgen.1000504
Dobson RJ, Munroe PB, Caulfield MJ et al. (2009). Global sequence properties for superfamily prediction: a machine learning approach.. J Integr Bioinform Vol.6, (1) 109-.
10.2390/biecoll-jib-2009-109
Newhouse S, Farrall M, Wallace C et al. (2009). Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.. PLoS One Vol.4, (4) e5003-.
10.1371/journal.pone.0005003
Willer CJ, Speliotes EK, Loos RJF et al. (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. NAT GENET Vol.41, (1) 1061-4036 25-34.
10.1038/ng.287
Keating BJ, Tischfield S, Murray SS et al. (2008). Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies. PLOS ONE Vol.3, (10) 1932-6203 -.
10.1371/journal.pone.0003583
Caulfield MJ, Munroe PB, O'Neill D et al. (2008). SLC2A9 is a high-capacity urate transporter in humans.. PLoS Med Vol.5, (10) e197-.
10.1371/journal.pmed.0050197
Huq SM, Oldapo MNJ, Wang Y et al. (2008). High glucose and low lactate: a metabolic signature of hypertension in human serum?. HYPERTENSION Vol.52, (4) 0194-911X 758-759.
Hoti M, Newhouse S, Clayton D et al. (2008). WNK1 - functional analyses of variants associated with blood pressure and essential hypertension. J HUM HYPERTENS Vol.22, (10) 0950-9240 722-722.
Hoti M, Newhouse S, Clayton D et al. (2008). WNK1-functional analyses of variants associated with blood pressure and essential hypertension. HYPERTENSION Vol.52, (4) 0194-911X 764-764.
Delles C, Padmanabhan S, Lee WK et al. (2008). Glutathione S-transferase variants and hypertension. J HYPERTENS Vol.26, (7) 0263-6352 1343-1352.
Loos RJF, Lindgren CM, Li SX et al. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. NAT GENET Vol.40, (6) 1061-4036 768-775.
10.1038/ng.140
Weedon MN, Lango H, Lindgren CM et al. (2008). Genome-wide association analysis identifies 20 loci that influence adult height. NAT GENET Vol.40, (5) 1061-4036 575-583.
10.1038/ng.121
Dobson RJB, Munroe PB, Mein CA et al. (2008). Combining protein-protein interaction (PPI) network and sequence attributes for predicting hypertension related proteins. BIOINFORMATICS RESEARCH AND DEVELOPMENT, PROCEEDINGS Vol.13, () 1865-0929 377-391.
Wallace C, Newhouse SJ, Braund P et al. (2008). Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. AM J HUM GENET Vol.82, (1) 0002-9297 139-149.
10.1016/j.ajhg.2007.11.001
Freel EM, Ingram M, Friel EC et al. (2007). Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. CLIN ENDOCRINOL Vol.67, (6) 0300-0664 832-838.
10.1111/j.1365-2265.2007.02971.x
Wallace C, Newhouse SJ, Braund P et al. (2007). Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease. CIRCULATION RESEARCH Vol.101, (11) 0009-7330 1208-1208.
Newhouse SJ, Wallace C, Hoti M et al. (2007). Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis. CIRCULATION RESEARCH Vol.101, (11) 0009-7330 1208-1208.
Wallace C, Dobson RJ, Munroe PB et al. (2007). Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates.. Genome Res Vol.17, (11) 1088-9051 1596-1602.
10.1101/gr.5996407
Padmanabhan S, Davies E, MacKenzie SM et al. (2007). Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. J HUM HYPERTENS Vol.21, (10) 0950-9240 837-837.
Newhouse S, Wallace C, Hoti M et al. (2007). Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes. J HUM HYPERTENS Vol.21, (10) 0950-9240 831-831.
Padmanabhan S, Menni C, Delles C et al. (2007). Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study. J HUM HYPERTENS Vol.21, (10) 0950-9240 843-843.
Marcano ACB, Burke B, Gungadoo J et al. (2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. J MED GENET Vol.44, (9) 0022-2593 -.
10.1136/jmg.2007.049718
Burton PR, Clayton DG, Cardon LR et al. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. NATURE Vol.447, (7145) 0028-0836 661-678.
10.1038/nature05911
Barr M, MacKenzie SM, Friel EC et al. (2007). Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. HYPERTENSION Vol.49, (1) 0194-911X 113-119.
10.1161/01.HYP.0000249904.93940.7a
Delles C, Braga-Marcano AC, Munroe PB et al. (2006). Association between variants of the human GSTM gene family and hypertension. HYPERTENSION Vol.48, (4) 0194-911X E27-E27.
Padmanabhan S, Hastie CE, Wallace C et al. (2006). Familial atherosclerotic disease and hypertension localised to chromosome 7p in the British genetics of hypertension study. HYPERTENSION Vol.48, (4) 0194-911X E98-E98.
Wallace C, Xue MZ, Newhouse SJ et al. (2006). Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension.. Am J Hum Genet Vol.79, (2) 0002-9297 323-331.
10.1086/506370
Munroe PB, Wallace C, Xue MZ et al. (2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study.. Hypertension Vol.48, (1) 105-111.
10.1161/01.HYP.0000228324.74255.f1
Padmanabhan S, Wallace C, McBride MW et al. (2006). Genomewide linkage analysis for loci affecting electrocardiographic LV mass. JOURNAL OF HYPERTENSION Vol.24, () 0263-6352 S330-S330.
Delles C, Marcano ACB, Munroe PB et al. (2006). Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension. JOURNAL OF HYPERTENSION Vol.24, () 0263-6352 S13-S13.
Bell JT, Wallace C, Dobson R et al. (2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. HUM MOL GENET Vol.15, (8) 0964-6906 1365-1374.
10.1093/hmg/ddl058
Padmanabhan S, Wallace C, Munroe PB et al. (2006). Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. HYPERTENSION Vol.47, (3) 0194-911X 603-608.
10.1161/01.HYP.0000197947.62601.9d
Binder A, Garcia E, Wallace C et al. (2006). Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. J HYPERTENS Vol.24, (3) 0263-6352 471-477.
10.1097/01.hjh.0000209983.28735.33
Dobson RJ, Munroe PB, Caulfield MJ et al. (2006). Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.. BMC Bioinformatics Vol.7, () 217-.
10.1186/1471-2105-7-217
Tobin MD, Raleigh SM, Newhouse S et al. (2005). Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. CIRCULATION Vol.112, (22) 0009-7322 3423-3429.
10.1161/CIRCULATIONHA.105.555474
Padmanabhan S, Wallace C, Munroe PB et al. (2005). Chromosome 2p shows genome wide significant linkage to of anti-hypertensive medication response in the British genetics of hypertension (BRIGHT) study.. HYPERTENSION Vol.46, (5) 0194-911X 886-886.
Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish genetics of Hypertension (BRIGHT) study. HYPERTENSION Vol.46, (5) 0194-911X 877-877.
Munroe PB, Wallace C, Mein C et al. (2005). Enhanced support for linkage to chromosome 5q13.1 and hypertension in the British Genetics of Hypertension (BRIGHT) study.. HYPERTENSION Vol.46, (4) 0194-911X 892-892.
Wallace C, Xue MZ, Dobson R et al. (2005). Loci on chromosomes 5p and 20q are linked to multiple hypertension phenotypes in the BRItish Genetics of HyperTension (BRIGHT) study. HYPERTENSION Vol.46, (4) 0194-911X 877-877.
Xue MZ, Wallace C, Dobson R et al. (2005). Variants and haplotypes of the angiotensinogen gene are associated with hypertension in the Caerphilly Prospective Study. HYPERTENSION Vol.46, (4) 0194-911X 904-904.
Newhouse SJ, Wallace C, Dobson R et al. (2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.. Hum Mol Genet Vol.14, (13) 0964-6906 1805-1814.
10.1093/hmg/ddi187
Marcano AC, Onipinla AK, Caulfield MJ et al. (2005). Recent advances in the identification of genes for human hypertension.. Expert Rev Cardiovasc Ther Vol.3, (4) 733-741.
10.1586/14779072.3.4.733
Mein CA, Caulfield MJ, Munroe PB (2005). Selection of candidate genes in hypertension.. Vol.108, () 107-129.
Munroe PB, Dobson R, Pembroke J et al. (2004). The MRC BRIGHT study: Demographic and biochemical characteristics of the sibling-pair resource. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol.58, (6) 0306-5251 688-688.
Lee YW, Oh VMS, Garcia E et al. (2004). Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population. J HYPERTENS Vol.22, (11) 0263-6352 2111-2116.
10.1097/00004872-200411000-00012
Newhouse S, Dobson R, Wallace C et al. (2004). No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. JOURNAL OF HYPERTENSION Vol.22, () 0263-6352 S212-S212.
Mein CA, Caulfield MJ, Dobson RJ et al. (2004). Genetics of essential hypertension.. Hum Mol Genet Vol.13 Spec No 1, () 0964-6906 R169-R175.
10.1093/hmg/ddh078
Newhouse SJ, Garcia E, Caulfield M et al. (2003). Haplotype structure of the WNK1 gene and association studies in hypertensive populations. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol.56, (2) 0306-5251 245-245.
Munroe PB, Editorial Board (2003). Hypercholesterolaemia and vascular function: is the p22phox gene the missing link?. Clin Sci (Lond) Vol.105, (1) 0143-5221 11-12.
10.1042/CS20030106
Caulfield M, Munroe P, Pembroke J et al. (2003). Genome-wide mapping of human loci for essential hypertension.. Lancet Vol.361, (9375) 2118-2123.
10.1016/S0140-6736(03)13722-1
Knight J, Munroe PB, Pembroke JC et al. (2003). Human chromosome 17 in essential hypertension.. Ann Hum Genet Vol.67, (Pt 2) 0003-4800 193-206.
10.1046/j.1469-1809.2003.t01-1-00002.x
Garcia EA, Newhouse S, Caulfield MJ et al. (2003). Genes and hypertension.. Curr Pharm Des Vol.9, (21) 1381-6128 1679-1689.
10.2174/1381612033454513
Garcia EA, Aristizabal D, McEwen J et al. (2002). Guanine nucleotide binding 3 (GNB3) haplotype analysis in the Venecia-Colombia Latin-American blood pressure study.. AMERICAN JOURNAL OF HUMAN GENETICS Vol.71, (4) 0002-9297 366-366.
Caulfield M, Pembroke J, Dominiczak A et al. (2002). The MRC British Genetics of Hypertension Study - Genome-wide screen results. JOURNAL OF HYPERTENSION Vol.20, () 0263-6352 S7-S7.
Metherell LA, Akker SA, Munroe PB et al. (2001). Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity.. Am J Hum Genet Vol.69, (3) 0002-9297 641-646.
10.1086/323266
Leung KY, Greene ND, Munroe PB et al. (2001). Identification of a transactivation motif in the CLN3 protein.. IUBMB Life Vol.51, (5) 1521-6543 295-298.
10.1080/152165401317190798
Leung KY, Greene ND, Munroe PB et al. (2001). Analysis of CLN3-protein interactions using the yeast two-hybrid system.. Eur J Paediatr Neurol Vol.5 Suppl A, () 1090-3798 89-93.
10.1053/ejpn.2001.0472
Caulfield M, Papp J, Pembroke J et al. (2000). A new tool for checks of data precision within the MRC British genetics of hypertension study. J HYPERTENS Vol.18, () 0263-6352 S180-S180.
Munroe P, Sandhu M, Jadhav D et al. (2000). No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population. J HYPERTENS Vol.18, () 0263-6352 S178-S178.

News

Web cast describing our gene discoveries for blood pressure and cardiovascular disease at:
http://www.youtube.com/watch?v=WVqxqb0_Ljk&feature=related

 

Collaborators

Internal: Prof Amrita Aluwahlia; Dr Mike Barnes; Prof Mark Caulfield; Prof Adrian Hobbs; Prof Anthony Mathur; Prof Ken Suzuki; Prof Andy Tinker; Prof Shu Ye

External: Dr Sudhin Thayyil (Institute of Child Health); Dr Elly Cartwright (University of Manchester); Dr Tom Weaver (MRC Harwell) Dr Pim Van Der Harst (University of Groningen) Dr Peter van der Meer (University of Groningen) Dr Folkert Asselbergs (University of Utrecht) Dr Brendan Keating (University of Pennsylvania) Dr JP Casas (University College London) Dr Andrew Morris (University of Oxford) Professor Nilesh Samani, (Leicester University) Dr Eleftheria Zeggini, (Sanger Institute, Cambridge) Dr Chris Newton-Cheh (Harvard University) Dr Hattie Syme (Royal Veterinary College); Dr Yalda Jamshidi (St George's Hospital, London).

Contact

Patricia Munroe, BSc, MSc PhD, FBS
Professor of Melecular Medicine
Centre for Clinical Pharmacology
Barts and The London, Queen Mary's School of Medicine and Dentistry
John Vane Science Centre
Charterhouse Square
London, EC1M 6BQ
T: +44 (0) 20 7882 3586
E: This email address is being protected from spambots. You need JavaScript enabled to view it.

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