Prowle, John R

Senior Clinical Lecturer

Dr John R. Prowle MA MB BChir MSc MD FFICM FRCP

Dr Prowle is a Senior Clinical Lecturer in Intensive Care Medicine within Prof. Rupert Pearse’s Critical Care and Perioperative Medicine Research Group at Barts and the London School of Medicine and Dentistry, Queen Mary University of London and is an Honorary Consultant Physician in Intensive Care Medicine and Renal Medicine at the Royal London Hospital, Barts Health NHS Trust, London,

Dr Prowle graduated in medicine from the University of Cambridge in 1999 and undertook Doctoral Research under the supervision of Prof Rinaldo Bellomo in Melbourne, Australia leading to the award of his MD research doctorate in 2013.

Since 2009 he has co-authored over 60 peer-reviewed publications and book chapters, including chapters related to Acute Kidney Injury in forthcoming editions of the Oxford Textbook of Clinical Nephrology and the Oxford Textbook of Critical Care.

Summary of Research

Dr Prowle’s academic interests include the Pathogenesis, Diagnosis and Treatment and Outcomes of Acute Kidney Injury, Continuous Renal Replacement Therapies in the ICU, Fluid Therapy and Medical Complications of Major Surgery.


Key Publications

For a full list of publications click here

O'Connor ME, Kirwan CJ, Pearse RM, Prowle JR: Incidence and associations of acute kidney injury after major abdominal surgery. Intensive care medicine, 42: 521-530, 20162

Prowle JR, Kolic I, Purdell-Lewis J, Taylor R, Pearse RM, Kirwan CJ: Serum creatinine changes associated with critical illness and detection of persistent renal dysfunction after AKI. Clin J Am Soc Nephrol, 9: 1015-1023, 2014

Prowle JR, Kirwan CJ, Bellomo R: Fluid management for the prevention and attenuation of acute kidney injury. Nature reviews Nephrology, 10: 37-47, 2014

Prowle JR, Molan MP, Hornsey E, Bellomo R: Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Critical care medicine, 40: 1768-1776, 2012

Prowle JR, Chua HR, Bagshaw SM, Bellomo R: Clinical review: Volume of fluid resuscitation and the incidence of acute kidney injury - a systematic review. Crit Care, 16: 230, 2012

Prowle JR, Calzavacca P, Licari E, Ligabo EV, Echeverri JE, Haase M, Haase-Fielitz A, Bagshaw SM, Devarajan P, Bellomo R: Pilot double-blind, randomized controlled trial of short-term atorvastatin for prevention of acute kidney injury after cardiac surgery. Nephrology (Carlton), 17: 215-224, 2012

Prowle JR, Schneider A, Bellomo R: Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury. Crit Care, 15: 207, 2011

Prowle JR, Liu YL, Licari E, Bagshaw SM, Egi M, Haase M, Haase-Fielitz A, Kellum JA, Cruz D, Ronco C, Tsutsui K, Uchino S, Bellomo R: Oliguria as predictive biomarker of acute kidney injury in critically ill patients. Crit Care, 15: R172, 2011

Prowle JR, Echeverri JE, Ligabo EV, Sherry N, Taori GC, Crozier TM, Hart GK, Korman TM, Mayall BC, Johnson PD, Bellomo R: Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality. Crit Care, 15: R100, 2011

Prowle JR, Echeverri JE, Ligabo EV, Ronco C, Bellomo R: Fluid balance and acute kidney injury. Nature reviews Nephrology, 6: 107-115, 2010

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