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Professor Grossman received an Open Exhibition from St. Catharine's College, University of Cambridge, then qualified with a BA in Psychology and Social Anthropology, and a BSc in Neuroanatomy, from the University of London. He graduated from University College Hospital Medical School in 1975 with the University of London Gold Medal, and has been with the Department of Endocrinology in this institution since 1978. He has co-authored nearly 600 original papers and review articles in endocrinology, edited the textbook Clinical Endocrinology (1992, 1997), was previously Editor of the journal Clinical Endocrinology, is Section Editor for De Groot's Endocrinology (5th/6th editions), and is on the Editorial Board of a number of journals. He is on the Council of the Society for Endocrinology as Chairman of the Public Engagement Committee of the European Neuroendocrine Association, and is Chairman of the UK and Ireland Neuroendocrine Tumour Society from 2008 onwards. He previously served on the Ministry of Defence Advisory Committee on Research into the Gulf War Syndrome, is currently MD co-ordinator for the University of London, and is Regional Adviser for North East Thames in Endocrinology and Diabetes for the Royal College of Physicians. In 2001 he was elected Fellow of the Academy of Medical Sciences. He is Associate Editor of Endocrine Related Cancer. |
Current research interests
His research originally centred on understanding the regulation and control of hypothalamic hormones, which in turn control the pituitary and their relevant target glands. This work has extended back many years, initially focusing on the role of opioid peptides such as the endorphins in the regulation of the pituitary-adrenal 'stress' axis and of the sympathetic nervous system, and was expanded into an investigation of the relationship between the immune system and the central nervous system. |
More recently, his laboratory has focussed on the novel hormone ghrelin and its involvement in appetite, growth and metabolism, and on the pathogenesis of pituitary tumours especially cushing's disease. These research areas are being carried out in collaboration with Dr. Marta Korbonits (Reader in Endocrine Research). This work has been extended to the investigation of neuroendocrine tumours in general, including adrenal carcinomias and changes in their signalling pathways basally and in response to putative therapies.
Clinical Activity
From the clinical view point, his work has focused on the identification, diagnosis and assessment of treatment for a variety of pituitary tumours, and particularly the diagnosis and differential diagnosis of Cushing's syndrome. This has now been extended to an investigation of the molecular pathogenesis of Cushing's disease, as well as of pituitary tumours which recur in spite of conventional treatment. Further specific interests include the diagnosis and investigation of phaeochromocytomas and other neuroendocrine tumours, including carcinoids, and particularly the use of radioisotopes such as MIBG and other radionuclides in the treatment of malignant phaeochro-mocytomas and carcinoid tumours. |
Recent Publications
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McCormack, A., Gill, A.J., McDonald, K.L., Clark, S.J., Burt, M.G., Campbell, K., Braund, W.J., Little, N.S., Cook, R.J., Grossman, A.B., Robinson, B.G. and Clifton-Bligh, R.J. (2009). Low MGMT expression is associated with response to temozolomide in aggressive pituitary tumors. Clin. Endocrinol., 72, 226-233.
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Druce, M.R., Kaltsas, G.A., Fraenkel, M., Gross, D.J and Grossman, A.B. (2009). Novel and evolving therapies in the treatment of malignant phaeochromocytoma: Experience with the mTOR inhibitor everolimus (RAD001). Horm. Metab. Res., 41, 697-702.
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Procopiou, M., Finney, H., Akker, S.A., Chew, S.L., Drake, W.M., Burrin, J., and Grossman, A.B. (2009). Evaluation of an enzyme immunoassay for free plasma metanephrines in the diagnosis of catecholamine–secreting tumors. Eur. J. Endocrinol., 161, 131-40.
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Alexandraki, K.I., Kaltsas, G.A., Le Roux, C.W., Fassnacht, M., Ajodha, S., Christ-Crain, M., Akker, S.A., Drake, W.M, Edwards, R., Allolio, B. and Grossman, A.B. (2009). Assessment of serum free cortisol levels in patients with adrenocortical carcinoma treated with mitotane. Clin. Endocrinol., in press.
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Alexandraki, K.I., Kaltsas, G.A., Isidori, A.M., Akker, S.A., Drake, W.M., Chew, S.L., Monson, J.P Besser, G.M. and Grossman, A.B. (2009). The prevalence and characteristic features of cyclicity and variability in Cushing’s disease. Eur. J. Endocrinol., 160, 1011-8.
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Dworakowska, D., Wlodek, E., Igreja, S., Leontiou, C.A., Cakir, M., Teng, M., Prodromou, N., Góth, M.I., Grozinsky-Glasberg, S., Gueorguiev, M., Korbonits, M. and Grossman, A.B. (2009). Activation of B-Raf/MEK/ERK and PI3k/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors. Endocr. Relat. Cancer, in press.
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Coelho, C., Druce, M. and Grossman, A.B. (2009). Diagnosis of insulinoma in a patient with hypoglycemia without obvious hyperinsulinemia. Nature Rev. Endocrinol., 5, 628-632.
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Kelly, P., Maher, K., Chew, S.L., Monson, J.P., Grossman A.B. and Jenkins PJ (2009). A single-center open-label study to investigate the efficacy and safety of repeat subcutaneous injections of lanreotide autogel (atg; somatuline depot) in patients with acromegaly previously treated with octreotide. Endocrine Pract., in press.
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Christ-Crain, M., Stolz, D., Jutla, S., Couppis, O., Müller, C., Bingisser, R., Schuetz, P., Tamm, M., Edwards, R., Müller, B and Grossman, A.B. (2007). Free and total serum cortisol levels as predictors of severity and outcome in community-acquired pneumonia. Am. J. Resp. Med. Crit. Care 176, 913-920 .
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