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I work as an academic at Queen Mary's and an Honorary Consultant Cardiologist at Bart and the London NHS Trust. I divide my time equally between clinical work and basic science with the aim of conducting translational research. My basic science interests have evolved from my PhD undertaken at UCL where I gained an understanding of platelet and stem cell biology as well as cellular bioenergetics. These interests are now consolidated in my work looking at the mechanisms by which stem cells may improve cardiac function. My clinical work is directed at interventional cardiology and the management of patients with heart failure and angina who have failed conventional therapy. I am Secretary of the ESC Task force on Stem cells in cardiovascular disease and also Chair the clinical group of the British Cardiac stem cells collaborative set up by Professor John Martin. These roles have enabled me to design a series of clinical trials that will address some of the outstanding issues surrounding the use of stem cells to treat cardiovascular disease. I also have a major interest in the use of advanced cardiac imaging for translational research and have the role of Lead Clinician for Advanced Cardiac Imaging.
Current research interests
My basic science interests are directed at understanding the role of cell therapy in the treatment of cardiovascular disease. This covers a broad spectrum of research ranging form a study of the mechanism by which cell therapy may improve cardiac function to optimisation of cell therapies to ultimately produce cardiac regeneration. My clinical research is directed at new treatments for the 'no-option' patient - that is people who have cardiac disease and no further conventional treatments available to treat on-going symptoms. I am the chief investigator of one of the largest clinical trials to date looking at the role of stem cells in cardiac repair for patients with heart failure.
Key publications
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Bartunek J, Dimmeler S, Drexler H, Fernandez-Aviles F, Galinanes M, Janssens S, Mathur A et al. The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J (published on line March 2006)
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Mathur A & Martin JF. Stem Cells and Repair of the Heart. Lancet. (2004) Jul 10;364(9429):183-92.
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Lovell MJ & Mathur A. The role of stem cells for treatment of cardiovascular disease.
Cell Prolif. (2004) Feb;37(1):67-87 -
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S, Hobbs AJ. Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A. (2004) Jan 23. e-pub
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Mathur A, Hong Y, Martin JF, Erusalimsky JD. Megakaryocytic differentiation is accompanied by a reduction in cell migratory potential. Br J Haematol. (2001);112(2):459-465
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Mathur A, Hong Y, Kemp BK, Barrientos AA, Erusalimsky JD. Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes. Cardiovasc Res. (2000);46(1):126-38.
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Beltran B, Mathur A, Duchen MR, Erusalimsky JD, Moncada S. The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proc Natl Acad Sci U S A. (2000); 97(26): 14602-14607
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Genever PG, Wilkinson DJ, Patton AJ, Peet NM, Hong Y, Mathur A et al. Expression of a functional N-methyl-D-aspartate-type glutamate receptor by bone marrow megakaryocytes. Blood (1999);93(9):2876-83
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