Contact Details:

yun.zhang@qmul.ac.uk

After qualified in medicine from Tong Ji Medical College, Dr Zhang had further clinical and research training and obtained a Master degree from Peking Union Medical Collage. She was awarded a DPhil from the University of Oxford in 1996 and she won a Canadian Diabetes Association Fellowship to continue her research at the renowned Banting and Best Diabetes Centre at Toronto. Dr Zhang went back to Oxford in 1999 where she worked as a Senior Genetics Research Fellow before she joined the William Harvey Research Institute as Lecturer in Molecular Genetics in 2009.

 

Current research interests

Dr Zhang's research has focused on studies of the genetics of human complex diseases including hypertension, in which many genes and environmental factors interact to influence the disease concerned. Her current primary research is to identify the biological role of the genes associated with hypertension.

Key Publications

 

• Zhang Y, Castori M, Ferranti G, Paradisi M, Wordsworth BP. Novel and recurrent LEMD3 mutations causing Buschke-Ollendorff syndrome and osteopoikilosis but not isolated melorheostosis. Clinical Genet (2009) 75:556-561.
  
  
• Couto A, Armas JB, Brown MA, Peach CA, Smith R, Wordsworth BP, Zhang Y. New mutations in the gene LEMD3 in patients with osteopoikilosis and melorheostosis – evidence for genetic heterogeneity. Calcif Tissue Int (2007) 81:81-84.
  
  
• Zhang Y, Brown MA, Peach CA, Russell RG, Wordsworth BP. Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis. Rheumatol (2007) 46:586-589.
  
  
• Zhang Y, Brown MA. Genetic studies of chondrocalcinosis. Curr Opin Rheum (2005) 173:330-335.
  
  
• Zhang Y, Johnson K, Russell GR, Wordsworth BP, Carr A, Terkeltaub R, Brown MA. Association of "sporadic" chondrocalcinosis with a -4 bp G to A transition in the 5'-untranslated region of ANKH that promotes enhanced ANKH expression and extracellular PPi excess. Arthritis Rheum (2005) 52:1170-1117.
  
  
• Timms A, Zhang Y (shared first authorship), Bradbury L, Wordsworth BP, Brown MA. The Role of ANKH in Ankylosing Spondylitis, Arthritis Rheum (2003) 48:2898-2902.
  
  
• Williams C, Zhang Y (shared first authorship), Timms A, Bonavita G, Caeiro F, Broxholme J, Cuthbertson J, Jones Y, Marchegiani R, Reginato A, Russell R, Wordsworth P, Carr A, Brown M. Autosomal Dominant Familial Calcium Pyrophosphate Dihydrate Deposition Disease Is Caused by Mutation in the Transmembrane Protein ANKH. Am J Hum Genet (2002) 71:985-991.
  

 

 

 

 

 

 

 

 

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