Pre-clinical and intercalated B.Sc. studies at Leeds University (with Distinction in Anatomy). Qualified and graduated in Clinical Medicine from Cambridge University (with Distinction in Medicine, and Charles and Iris Brook Prize for Clinical Medicine from Caius College). Junior hospital posts in at Addenbrooke's Hospital (Cambridge), Ipswich Hospital, St Bartholomew's Hospital (London), University Hospitals Leuven (Belgium) and Stuivenberg General Hospital (Belgium). M.R.C. Research Training Fellowship with Adrian Clark and Richard Ross (1992-1995). Appointed Honorary Consultant Physician at St Bartholomew's Hospital, London in 1995. M.D. from Cambridge University (for which awarded the Sir Lionel Whitby Medal from Cambridge University) . Wellcome Trust Advanced Research Fellowship with Ian Eperon (University of Leicester 1996-1998). Wellcome Trust Advanced Research Fellowship with Adrian Krainer (Cold Spring Harbor Laboratory, USA 1998-1999). Elected F.R.C.P. (London) 1998.

 

Clinical work

 

• Regulation of messenger (m)RNA splicing by endocrine systems
• Familial endocrine tumour syndromes
• Endocrine tumours and cancers
• Endocrine medicine

 

 

Key publications

 

• Khoo B, Roca X, Chew SL, Krainer AR. Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB. BMC Mol Biol. (2007) Jan 17;8:3.

• Agha A, Walker D, Perry L, Drake WM, Chew SL, Jenkins PJ, Grossman AB, Monson JP.  Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients. Clin Endocrinol (Oxf). (2007) Jan;66(1):72-7.

• Ogilvie CM, Brown PL, Matson M, Dacie J, Reznek RH, Britton K, Carpenter R, Berney D, Drake WM, Jenkins PJ, Chew SL, Monson JP.  Selective parathyroid venous sampling in patients with complicated hyperparathyroidism. Eur J Endocrinol. (2006) Dec;155(6):813-21.

• Colson A, Brooke AM, Walker D, Besser GM, Chew SL, Grossman AB, Jenkins PJ, Drake WM, Monson JP. Growth hormone deficiency and replacement in patients with treated Cushing's Disease, prolactinomas and non-functioning pituitary adenomas: effects on body composition, glucose metabolism, lipid status and bone mineral density. Horm Res. (2006); 66(6):257-67. Epub 2006 Aug 17.

• Smith PJ, Zhang C, Wang J, Chew SL, Zhang MQ, Krainer AR. An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers. Hum Mol Genet. (2006) Aug 5;15(16):2490-508. Epub 2006 Jul 6.

• Priesemann M, Davies KM, Perry LA, Drake WM, Chew SL, Monson JP, Savage MO, Johnston LB.  Benefits of screening in von Hippel-Lindau disease comparison of morbidity associated with initial tumours in affected parents and children. Horm Res. (2006); 66(1):1-5. Epub 2006 Apr 27.

• Chik Z, Johnston A, Tucker AT, Chew SL, Michaels L, Alam CA.  Pharmacokinetics of a new testosterone transdermal delivery system, TDS-testosterone in healthy males. Br J Clin Pharmacol. (2006) ar;61(3):275-9.

 

 

A highly-illustrated textbook of clinical endocrinology and diabetes mellitus has been written by Shern L. Chew and David R. Leslie. The textbook is intended for senior clinical medical students, junior doctors and endocrinologists in training. The book won the first prize in the Endocrinology category of the BMA book competition in 2006

Another highly illustrated textbook for pre-clinical medical students has been written by Joy Hinson, Peter Raven and Shern L. Chew. This focuses on clinically relevant anatomy, physiology and biochemistry. It will be available in the later part of 2007.  

 

 

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