Contact Details:

m.r.druce@qmul.ac.uk

Dr Maralyn Druce undertook undergraduate training at Christ's College, Cambridge University and completed her clinical training at UCLSM in 1994. She completed her higher medical training in Diabetes, Endocrinology and General Internal Medicine at the Hammersmith Hospital and Barts Hospital. She was awarded a Wellcome Trust clinical research training fellowship and obtained a PhD in physiology in Professor Steve Bloom's laboratory in Imperial College, focusing on gut hormones and their role in the peripheral and central control of energy homeostasis. She was awarded the Chadburn Lectureship at Barts and the London School of Medicine and is Honorary Consultant in Endocrinology at Barts and the London NHS Trust.

Current research interests

 

Her current clinically-based research interests include:

• Pathophysiology, diagnosis and treatment of neuroendocrine tumours. This includes studies on fibrosis in the carcinoid syndrome and the use of targeted radionuclide therapy in the treatment of endocrine malignancy. She is also involved in industry-sponsored clinical trials of novel pharmacological therapies
  
  
• Factors affecting the production of catecholamines and metanephrines.
  
  
• Endocrine effects of cancer therapies.
  
  
• Gut hormones in the pathophysiology and treatment of obesity.

In addition she has a strong interest in medical and endocrine education.

 

 

Key publications

 

• Druce MR, Kaltsas GA, Fraenkel M, Gross DJ, Grossman AB. (2009) Novel Therapies for malignant phaeochromocytoma: experience with the mTOR inhibitor everolimus. Hormone and Metabolism Research (epub ahead of print).
  
  
• Druce MR, Rockall A, Grossman AB. (2009) Fibrosis in the carcinoid syndrome: from causation to future therapies Nature Reviews Endocrinology (5) 276-283.
  
  
• Druce MR, Minnion JS, Field BCT, Patel SR, Cuenco-Shilito J, Tilby M, Beale KEL, Murphy KM, Ghatei MA, Bloom SR (2008). Investigation of Structure-Activity Relationships of Oxyntomodulin using Oxyntomodulin analogues. Endocrinology. Dec 12 (Epub ahead of print).
  
  
• Druce MR, Neary NM, Small CJ, Milton JE, Monteiro M, Patterson M, Ghatei MA and Bloom SR. (2006) Subcutaneous administration of ghrelin stimulates energy intake in healthy lean human volunteers. Int J Obes Relat Metab Disord. Feb 30 (2) 293-6.
  
  
• Druce MR and Bloom SR (2006) Oxyntomodulin: a novel potential treatment for obesity. Treat Endocrinol. 5(5):265-72.
  
  
• Druce MR and Bloom SR (2006) Regulation of Appetite. Archives of Disease in Childhood Feb 91(2) 183-7.
  
  
• Druce MR, Wren AM, Park AJ, Milton JE, Patterson M, Frost G, Ghatei MA, Small C and Bloom SR. (2005) Ghrelin increases food intake in obese as well as lean subjects. Int J Obes Relat Metab Disord. Sep 29 (9) 1130-6.
  
  
• Druce MR, Small CJ and Bloom SR (2004) Minireview: Gut Peptides Regulating Satiety. Endocrinology Jun 145 (6) 2660-5.

 

 

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