Contact Details: a.johnston@qmul.ac.uk

 

For his first degree, Professor Johnston read Biochemistry and Toxicology at the University of Surrey during which he spent a year of research with Sandoz, Basel, Switzerland. After graduating, he spent two years working with Professor David Bowen at Charing X Hospital Medical School in the Department of Forensic Medicine and Toxicology. He then joined Dr John Hamer at St Bartholomew's Hospital where he undertook his research training in clinical pharmacology with the late Professor Paul Turner and gained his doctorate in Pharmacology from the University of London. Professor Johnston also holds a Masters degree in Applied Statistics from Sheffield Hallam University. He is a Fellow of the Royal College of Pathologists, the British Pharmacological Society and the Royal Statistical Society and is a State Registered Clinical Scientist and Chartered Scientist.

 

Current research interests

 

Professor Johnston has over 30 years experience in the measurement of drug concentrations as a guide to therapy and in relation to toxicity. His research interests are in clinical trial design and statistical data analysis, modelling pharmacokinetics and pharmacodynamics, and in optimal use of immunosuppressive, cardiovascular, analgesic and anti-cancer drugs. He has published over two hundred and fifty articles in peer-reviewed journals. He is a frequent speaker on a variety of issues relating drug concentrations and drug action in man.

Professor Johnston has advised several drug regulatory agencies on the quality of drug formulations and bioequivalence measurement. He has presented, contributed to, and written, expert reports for submission to the National Institute for Clinical Excellence (NICE) and the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK, the European Medicine Evaluation Agency (EMEA), the US Food and Drugs Administration (FDA) and other international drug regulatory authorities.

Professor Johnston has a commitment to continuing education. He has initiated and runs four Masters courses; Clinical Drug Development; Healthcare Research Methods; Analytical Toxicology (with Professor Robert Flanagan); and Forensic Medical Sciences (with Professor Peter Vanezis).

 

Key publications

 

• Al-Otaibi F, Tucker AT, Johnston A, Perrett D. Rapid analysis of tetracaine for a tape stripping pharmacokinetic study using short-end capillary electrophoresis. Biomed Chromatogr. 2009 May;23(5):488-91.
  
  
• Chik Z, Johnston A, Tucker AT, Kirby K, Alam CA. Correcting endogenous concentrations of testosterone influences bioequivalence and shows the superiority of TDS(R)-testosterone versus Androgel(R). Int J Clin Pharmacol Ther. 2009 Apr;47(4):262-8.
  
  
• He X, Moore J, Shabir S, Little MA, Cockwell P, Ball S, Johnston A, et al. Comparison of the predictive performance of eGFR formulae for mortality and graft failure in renal transplant recipients. Transplantation. 2009 Feb 15;87(3):384-92.
  
  
• Mehta V, Johnston A, Cheung R, Bello A, Langford RM. Intravenous parecoxib rapidly leads to COX-2 inhibitory concentration of valdecoxib in the central nervous system. Clin Pharmacol Ther. 2008 Mar;83(3):430-5.
  
  
• Moore J, He X, Cockwell P, Little MA, Johnston A, Borrows R. The Impact of Hemoglobin Levels on Patient and Graft Survival in Renal Transplant Recipients. Transplantation. 2008 Aug 27;86(4):564-70.
  
  
• Cattran DC, Alexopoulos E, Heering P, Hoyer PF, Johnston A, Meyrier A, et al. Cyclosporin in idiopathic glomerular disease associated with the nephrotic syndrome : workshop recommendations. Kidney Int. 2007 Dec;72(12):1429-47.
  
  
• Chik Z, Johnston A, Tucker AT, Burn RT, Perrett D. Validation and application of capillary electrophoresis for the analysis of lidocaine in a skin tape stripping study. Biomed Chromatogr. 2007 Aug;21(8):775-9.
  
  
• Fredericks S, Jorga A, MacPhee IA, Reboux S, Shiferaw E, Moreton M, Johnston A, et al. Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements. Clin Transplant. 2007 Mar-Apr;21(2):252-7.
  
  
• Marlowe SN, Leekassa R, Bizuneh E, Knuutilla J, Ale P, Bhattarai B, Johnston A, et al. Response to ciclosporin treatment in Ethiopian and Nepali patients with severe leprosy Type 1 reactions. Trans R Soc Trop Med Hyg. 2007 Oct;101(10):1004-12.
  
  

 

 

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