Contact Details:

p.s.kabouridis@qmul.ac.uk

Panos Kabouridis received his PhD in Molecular Biology from the University of California at San Diego and San Diego State University (joint doctoral program) in 1994, and has worked as a post-doctoral fellow at the National Institute for Medical Research (MRC) at Mill Hill. In 2000, he joined Barts and The London SMD after receiving a Career Development Fellowship from The Wellcome Trust. Panos Kabouridis has a long-standing interest in understanding mechanisms of signal transduction during activation of T lymphocytes with special emphasis on signalling abnormalities in chronic inflammation and autoimmunity. In this context, he is developing specific inhibitors and establishes methods of delivery, with the aim to down-regulate the activity of such signalling cascades in pathological conditions. In parallel, he is studying the trafficking and mechanisms of regulation of the tyrosine kinase Lck, an enzyme essential for T cell activation. Recent work, in close collaboration with Dr Liz Jury, has shown that Agrin, a protein required for neuromuscular synapse formation, is expressed by T cells where it functions as a co-stimulatory receptor. Interestingly, this work has shown that Agrin is over-expressed in autoimmune T cells from lupus erythematosus patients. Ongoing work explores the molecular mechanisms via which Agrin regulates T cell function.

 

Key Publications

 

• E. C. Jury, P. S. Kabouridis, F. Flores-Borja, R. A. Mageed and D. A. Isenberg. Altered lipid raft-associated signalling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J. Clin. Invest. 2004, 113: 1176-1187.
  
  
• N. M. Blackwell, P. Sembi, J. Newson, T. Lawrence, D. W. Gilroy and P. S. Kabouridis. Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by administration of a membrane-permeable IB repressor. Arthr. Rheum. 2004, 50: 2675-2684. *Also see accompanying editorial article by G. S. Firestein. NF-B: Holy Grail for Rheumatoid Arthritis? Arthr. Rheum. 2004, 50: 2381-2386.
  
  
• F. Flores-Borja, P. S. Kabouridis, E. C. Jury, D. A. Isenberg and R. A. Mageed. Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis & Rheumatism. 2005, 52, 3955 - 3965.
  
  
• E. C. Jury, F. Flores-Borja, and P. S. Kabouridis. Lipid Rafts in T cell Signalling and Disease. Sem. Cell Dev. Biol. 2007, 18: 608-615.
  
  
• E. C. Jury, J. Eldridge, D. A. Isenberg, P. S. Kabouridis. Agrin Signalling Contributes to Cell Activation and Is Overexpressed in T Lymphocytes from Lupus Patients. J. Immunol. 2007, 179: 7975-7983.
  
  
• Kabouridis PS, Jury EC. Lipid rafts and T-lymphocyte function: Implications for autoimmunity. FEBS Letters. 2008, 582, 3711-3718.
  
  
• N. M. Malik, D. W. Gilroy, P. S. Kabouridis. Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras. FEBS Lett. 2009, 583: 61-69.
  
  
• A. Koutsokeras and P. S. Kabouridis. Secretion and uptake of TAT-fusion proteins produced by engineered mammalian cells. Biochim. Biophys. Acta. 2009, 1790: 147-153.
  
  
• P. S. Kabouridis. Lipid rafts in T cell receptor signalling. Molecular Membrane Biology, (2006), 23, 49 - 57
  

 

 

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