Contact Details:

r.a.mageed@qmul.ac.uk

Rizgar Mageed qualified as a pharmacist from the College of Pharmacy at Baghdad University in Iraq in 1976. Started postgraduate studies at the Royal London Hospital School of Medicine in 1981 and was awarded a PhD degree at London University in 1985. Immediately prior to this award, Professor Mageed was appointed Research Fellow at the Department of Immunology University of Birmingham Medical School where he worked from 1984 till 1990 when he joined the Kennedy Institute of Rheumatology as a Senior Scientist. In 1996, Prof. Mageed was appointed Senior Lecturer at Imperial College. In 2000, Prof. Mageed awarded an Arthritis Research Campaign Fellowship and appointed Senior Lecturer at the Centre for Rheumatology at University College London. Prof. Mageed was appointed to his current position as Professor of Experimental Immunology at the Bone and Joint Research Unit at the William Harvey Institute in December 2002.

 

Current research interests

 

Prof. Mageed’s research interests are in understanding the role of B-lymphocytes in autoimmune diseases. A principal line of interest has been in studying the structure and genetics of autoantibody production. These studies revealed disease- and site-specific clonal expansion of B-lymphocytes in patients with rheumatoid arthritis and systemic lupus erythematosus. More recent studies examined the mechanisms that cause autoantibody production and B-lymphocyte defects. These studies have revealed basic abnormalities in the regulation of intracellular signalling mechanisms in B-lymphocytes. Prof. Mageed is currently developing genetic approaches and stem cells to restore normal intracellular signalling and biology in B-lymphocytes in autoimmune diseases.

 

Key publications

 

• Garaud S, Le Dantec C, Jousse-Joulin S, Hanrotel-Saliou C, Saraux A, Mageed RA, Youinou P, Renaudineau Y. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol 2009; 182: 5623-32.
  
  
• Alard J-E, Dueymes M, Mageed RA, Saraux A, Youinou P, Jamin C. CCR5 in association with HSP70 promotes apoptosis induced by anti-HSP60 antibody. FASEB J 2009; 23: 2772-9.
  
  
• Rochas C, Hillion S, Saraux A, Mageed RA, Youinou P, Jamin C, Valérie Devauchelle V. Transmembrane BAFF from rheumatoid synoviocytes requires IL-6 to inducethe expression of RAG in B lymphocytes. Arthritis Rheum 2009, 60: 1261-71.
  
  
• Flores-Borja F, Kabouridis PS, Jury EC, Isenberg DA, Mageed RA. Altered lipid raft-associated proximal signalling and translocation of CD45 tyrosine phosphatase in B-lymphocyte from patients with lupus disease. Arthritis Rheum (2007); 56: 291-302

• Y Renaudineau, S Hillion, A Saraux, Mageed RA, Youinou P. An alternative exon 1 of the cd5 gene regulates CD5 expression in human B lymphocytes. Blood (2005); 106: 2781-2789.

• Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, Isenberg DA. Altered lipid raft expression and associated signalling in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest (2004); 113: 1176-1187.

• Vencovský J, Jarošová K, Němcová D, Niederlová J, Ozen S, Růžičková Š, Ollier W, Mageed RA. Interleukin-1 receptor antagonist gene polymorphism in patients with juvenile idiopathic arthritis. Arthritis Rheum (2001); 44: 2387-2391.

• Lattesjö H, Burd GP, Mageed RA. CD4+ T lymphocytes with constitutive CD40 ligand in pre-autoimmune (NZB x NZW) F1 lupus-prone mice: phenotype and role in autoreactivity. J Immunol (2000); 165: 4095-104.

• Mageed RA, MacKenzie LE, Stevenson FK, Yuksel B, Shokri F, Maziak BR, Jefferis R, Lydyard PM. Selective expression of a VHIV subfamily of immunoglobulin genes in human CD5+ B-lymphocytes from cord blood. J Exp Med (1991); 174: 109-13.

 

 

 

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